On 28 Jul 2006 09:39:48 -0700, "Ace" <acemanvx@yahoo.com> wrote:

>Ophthalmology. 2004 Dec;111(12):2175-85.
>
>Wavefront-guided LASIK with the Zyoptix 3.1 system for the correction
>of myopia and compound myopic astigmatism with 1-year follow-up:
>clinical outcome and change in higher order aberrations.
>
>Kohnen T, Buhren J, Kuhne C, Mirshahi A.
>
>Department of Ophthalmology, Johann Wolfgang Goethe-University,
>Frankfurt am Main, Germany. kohnen@em.uni-frankfurt.de
>
>OBJECTIVE: To assess safety, efficacy, predictability, stability, and
>change in aberrations after wavefront-guided LASIK for myopia and
>myopic astigmatism.
>
>DESIGN: Prospective, nonrandomized, self-controlled trial.
>
>PARTICIPANTS: Wavefront-guided LASIK was performed in 97 eyes in a
>1-year trial. Treated eyes had a mean subjective manifest spherical
>equivalent (SE) of -5.22+/-2.07 diopters (D), with a range of -0.25 to
>-9.00 D of myopia and 0 to -3.25 D of astigmatism.
>
>INTERVENTION: After a microkeratome cut, a wavefront-based excimer
>ablation (Zyoptix 3.1) was performed. The full treatment to achieve
>emmetropia of an early nomogram provided by the system manufacturer was
>used in all procedures.
>
>MAIN OUTCOME MEASURES: Safety, efficacy, predictability, and stability
>were evaluated at 1, 3, and 12 months postoperatively. Wavefront
>changes of higher order aberrations (HOAs) at 1 year were determined
>for pupil sizes of 3.5 and 6 mm. RESULTS: At 1 year postoperatively,
>uncorrected visual acuity (VA) was 20/20 or better in 83% of the eyes,
>and 20/40 or better in 98%. The mean subjective manifest SE at 1 year
>was -0.25+/-0.43 D; it was within 0.50 D in 77% and within 1.0 D in
>95%. No eye lost > or =2 lines of best spectacle-corrected VA (BSCVA)
>at 1 year postoperatively; 40 eyes gained 1 line of BSCVA, and 5 eyes
>gained 2 lines. The total HOA root mean square (RMS) increased on
>average by a factor of 1.23+/-0.57 with a 3.5-mm pupil; for the 6 mm
>pupil, the increase factor was 1.52+/-0.36. No change or reduction in
>the total HOA RMS was observed in 45.5% of the eyes for a 3.5-mm pupil
>and in 20.6% for a 6-mm pupil. There was a significant increase of
>primary spherical aberration (Z 4,0) by a factor of 4.11+/-10.17 for
>3.5-mm pupils and 4.31+/-6.76 for 6-mm pupils.
>
>CONCLUSIONS: Wavefront-guided LASIK using Zyoptix 3.1 is an effective
>and safe procedure for the treatment of myopia and myopic astigmatism.
>Although in close to half of the eyes HOAs could be reduced, there was
>still undercorrection and induction of HOAs with the algorithm
>employed.
>
>

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