 Re: Curcumin ToPical quest
randall wrote:
> Hi,
>
> As i'm writing this i'm listening to a skin-zinc commercial on the
> radio. lol
>
>
> OK, so i E-mailed a link for psoria-gold to a friend today.
>
> After looking at the info again it raised a few things i wasn't
> tuned in to before.
>
> I used a home brewed concoction of olive oil and curcumin back in
> march/06 that
> seemed to work fine but was itchy and messy. Plus I'm really more
> concerned with
> my IP6 trial that's been going on for a year now.
>
> Can we get some folks here to experiment with psoria-gold? Or whip
> up your own topical with curcumin in it?
>
> http://psoriagold.com/site/
>
> After looking at the article below and list of ingredients (site above)
> i'm realizing now
> that i didn't have anything in the mix to get the curcumin to penetrate
> the
> skin.
>
> So, i may go back and do a trial with some ethanol or dmso added in.
>
> Not sure if this article was posted previously. As most of us around
> here have been eating the stuff, using it topically may be the key to
> it. 
>
>
> http://www.dermatologytimes.com/der..=17
8388
>
> Los Angeles - Curcumin - the potent yellow spice found in turmeric
> and curry powders - is effective in treating psoriasis as well as
> many other skin conditions, according to Madalene Heng, M.D.
>
> Dr. Heng, professor of medicine/dermatology at the university of
> California, Los Angeles, School of Medicine, has developed curcumin
> psoriasis and antiaging products sold under the names Psoria-Gold and
> Re-Juven (OmniCure).
>
> Results of a recent university of Texas study indicate that curcumin
> effectively halts the growth of, and eventually kills, melanoma cells
> in culture. Clinical trials also are under way to test the spice's
> effects on colon cancer, pancreatic cancer, multiple myeloma and breast
> cancer.
>
> Dr. Heng has already incorporated curcumin treatment into her practice
> as a treatment for all kinds of wounds, burns, sun-damaged skin,
> psoriasis, eczema and other inflammatory skin conditions.
>
> According to Dr. Heng, who has published many studies on the topic, it
> makes sense that curcumin would work on psoriasis.
>
> Psoriasis trigger
>
> The trigger for psoriasis is an injurious stimulus, which may be a
> wound, sunburn, allergic reaction or infection (bacterial, fungal or
> viral). The injury stimulus, usually together with a superimposed
> bacterial infection, triggers a wound healing response, leading to the
> generation of T lymphocytes, which generates tumor necrosis
> factor-alpha, new blood vessels, scar tissue and epidermal
> proliferation. These healing processes require a source of energy -
> namely, adenosine triphosphate, or ATP - which is generated from
> glycogen stores in the cells by phosphorylase kinase, an enzyme
> secreted five minutes after injury.
>
> According to Dr. Heng, in normal non-psoriatic individuals, there is a
> switch-off mechanism for phosphorylase kinase, and after the wound is
> healed, phosphorylase kinase levels return to normal and the energy
> supply to the inflammatory process is curtailed. This returns the skin
> to normal except for some post-inflammatory changes such as erythema,
> scarring and pigmentation.
>
> In psoriatic individuals, the switch-off mechanism for phosphorylase
> kinase is defective due to a defective Type II cAMP protein kinase
> linked to a defective gene on the distal end of the 17th chromosome
> (17q) (Tomfohrde J et al. Science 1994;264:1141-1145; Tournier S et al.
> J Cell Physiol 1996; 167:196-203; Sozzi G et al. Genes Chromosomes
> Cancer 1994;9:244-250). Increased phosphorylase kinase levels results
> in increased phosphorylation reactions, leading to the increased
> breakdown of glycogen stores to ATP, correlating with an increased
> epidermal proliferation and psoriatic activity (Heng MCY et al. Br J
> Dermatol 1994;130:298-306).
>
> Curcumin's effect
>
> "Curcumin, by lowering phosphorylase kinase levels in psoriatic
> epidermis, has been shown to result in resolution of psoriasis, and
> achieves this through decreasing the population of Ki-67 cells, i.e.,
> cells capable of dividing, within the epidermis. (Heng MCY et al. Br J
> Dermatol 2000;143:937-949)," she says. "While curcumin-untreated
> psoriatic controls possess numerous Ki-67 cells, curcumin-treated
> psoriatic epidermis possess few Ki-67 cells (Heng MCY et al. Br J
> Dermatol 2000;143:937-949). The rapid epidermal turnover associated
> with numerous Ki-67 cells results in generation of stratum corneum in
> four days in untreated psoriatic controls, compared to 60 days in
> curcumin-treated psoriatics, suggesting that a major defect in
> psoriatic controls is loss of the epidermal barrier (resembling that of
> a jellyfish), compared to curcumin-treated psoriatics.
>
> "In our patients, when the epidermal barrier is completely reformed (as
> shown by the skin appearance returning to normal), it has been observed
> that all treatment (including curcumin) may be stopped without
> recurrence of the psoriatic disease."
>
> At this point, Dr. Heng says, there is plenty of preclinical anecdotal
> evidence showing curcumin's benefits and that it is safe; clinical data
> is now needed to make the spice a part of mainstream treatment.
>
> --------------------------------------------------------------------------
----------------
>
> Didn't Manfred post some links or sniPPets a week back from another
> group?
>
> No wonder I"m still thinking about it.
>
> Let's see:
> http://groups.google.com/groups/sea..sis&qt_s=Search
>
> Oh ok. His thread was tumeric topically.
>
> Has it started to penetrate my skin and brain yet? LOL
>
>
> randall.. doing the toPicals. GET the Curcumin!
I have some curcumin capsules. I have found the powder inside mixes
well with glycerin. I was thinking of mixing the blend with some kind
of MSM cream what to ya think?
I don't have much P now as may derm has switched me from the cyclo to
Humira which I am using off label at this time. But I am still looking
for a more natural approach.
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