Oxidants and iron in progressive kidney disease.
Shah SV
J Ren Nutr. 2006 Jul ; 16(3): 185-9

Oxidants derived either from leukocytes in proliferative
glomerulonephritis or from resident glomerular cells in
nonproliferative glomerulonephritis have been shown to have several
biological effects relevant to chronic kidney disease. These include
the ability of oxidants to damage the glomerular basement membrane and
directly induce proteinuria, effects that would lead to a fall in the
glomerular filtration rate and account for the morphologic changes
observed in chronic kidney disease. In experimental models, the role of
oxidants has been shown in both proliferative glomerulonephritis (eg,
antiglomerular basement membrane antibody disease) as well as
experimental models of minimal change disease and membranous
nephropathy. Oxidants have also been shown to be an important mediator
of the various pathways that have been implicated in diabetic
nephropathy. Antioxidants and iron chelators have also been shown to
retard functional and morphologic changes observed in progressive
kidney disease. Taken together, these experimental studies suggest an
important role of oxidants in chronic kidney disease.

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