Methods Find Exp Clin Pharmacol. 2004 Jun;26(5):345-8.  Related Articles, Li
nks



The effects of oxcarbazepine on oxidative stress in epileptic patients.

Bolayir E, Celik K, Tas A, Topaktas S, Bakir S.

Department of Neurology, Cumhuriyet university Faculty of Medicine, Noroloji
,
Turkey. ebol@mynet.com

In the present study, erythrocyte lipid peroxidation, superoxide dismutase,
glutathione peroxidase and catalase activities were determined in epileptic
patients receiving oxcarbazepine monotherapy for 1 year and normal controls.
Glutathione peroxidase, catalase, superoxide dismutase and malondialdehyde
activities were investigated in a control group (15 normal healthy adults) a
nd
a group of 13 epileptic patients, before and after 1 year of oxcarbazepine
treatment. The values of glutathione peroxidase and superoxide dismutase
activities were statistically significant after 1 year of therapy and
pretreatment. The values of malondialdehyde were significantly different fro
m
the normal subjects and pretreatment patients values. This study suggests th
at
the antioxidant systems of epileptic patients receiving oxcarbazepine therap
y
for 1 year were significantly affected. (c) 2004 Prous Science. All rights
reserved.

PMID: 15319813 [PubMed - in process]

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