Title:  Natural antioxidants may prevent posttraumatic epilepsy: a
proposal based on experimental animal studies.
Author:  Mori A; Yokoi I; Noda Y; Willmore LJ
Abstract:  Head injury or hemorrhagic cortical infarction results in
extravasation of blood and breakdown of red blood cells and hemoglobin.
Iron liberated from hemoglobin, and hemoglobin itself, are associated
with the generation of reactive oxygen species (ROS) and reactive
nitrogen species (RNS). ROS and RNS have been demonstrated to be
involved in the mechanism of seizures induced by iron ions in the rat
brain, an experimental animal model for posttraumatic epilepsy (PTE).
ROS are responsible for the induction for peroxidation of neural
lipids, i.e., an injury of neuronal membranes, and also could induce
disorders in the excitatory and inhibitory neurotransmitters.
Antioxidants, such as a phosphate diester of vitamin E and C (EPC-K1)
and antiepileptic zonisamide, have been known to prevent the
epileptogenic focus formation, or to attenuate seizure activities in
the iron-injected rat brain. Natural antioxidants, such as
alpha-tocopherol, and condensed tannins, including (-)-epigallocatechin
and (-)-epigallocatechin-3-O-gallate, adenosine and its derivative,
melatonin, uyaku (Lindera Strychnifolia), fermented papaya
preparations, Gastrodia elata BI., and Guilingji, have been
demonstrated to scavenge ROS and/or RNS and to be prophylactic for the
occurrence of epileptic discharge in the iron-injected rat brain.
Journal:  Acta Medica Okayama
Issn:  0386300x
Year:  2004
Volume:  58
Issue:  3
Pages/rec. No.:  111-118




DOAJ - Directory of Open Access Journals, 2005, Lund University
Libraries, Head Office

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