<<snip>>
Removal of hepatic excess iron by phlebotomy significantly decreased
the serum levels of TRX and ALT in NASH patient.
<<snip>>

Hepatol Res. 2005 Oct 25; [Epub ahead of print] Related Articles, Links



Elevation of serum thioredoxin levels in patients with nonalcoholic
steatohepatitis.

Nakashima T, Sumida Y, Furutani M, Hirohama A, Okita M, Mitsuyoshi H,
Itoh Y, Okanoue T.

Department of Internal Medicine, Saiseikai Kyoto Hospital,
Imazato-minamihirao, Nagaoka-kyo, Kyoto 617-0814, Japan.

Thioredoxin (TRX) is induced by many oxidative stresses. Serum TRX
levels were significantly elevated in nonalcoholic steatohepatitis
(NASH) patients, as compared to simple fatty liver (FL) patients or
healthy controls. Serum TRX levels in NASH patients were significantly
correlated with serum ferritin levels, but not with other variables.
Removal of hepatic excess iron by phlebotomy significantly decreased
the serum levels of TRX and ALT in NASH patient. Therefore, the
pathogenesis of NASH may be associated with iron-related oxidative
stress. The serum TRX level is a parameter for discriminating NASH from
FL.

PMID: 16257259 [PubMed - as supplied by publisher]

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<ironjustice@aol.com> wrote in message
news:1130882148.708143.95120@g44g2000cwa.googlegroups.com..
> <<snip>>
> Removal of hepatic excess iron by phlebotomy significantly decreased
> the serum levels of TRX and ALT in NASH patient.
> <<snip>>
>
http://www.pharmexec.com/pharmexec/..l.jsp?id=185693

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