Does anyone know what kind of nutrients promote repair of mitochondrial DNA?

Ian

Report this post to a moderator

[  Post Follow-up to this message ]

<<snip>>
an iron chelator (phytic acid or deferoxamine) or a free radical
scavenger (sodium benzoate)
<<snip>>

Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1220-7. Epub 2004
Feb 6. Related Articles, Links


Mitochondrial-derived free radicals mediate asbestos-induced alveolar
epithelial cell apoptosis.

Panduri V, Weitzman SA, Chandel NS, Kamp DW.

Division of Pulmonary and Critical Care,Northwestern University
Feinberg School of Medicine, Chicago, IL 60611-3010, USA.

Asbestos causes pulmonary toxicity by mechanisms that in part involve
reactive oxygen species (ROS). However, the precise source of ROS is
unclear. We showed that asbestos induces alveolar epithelial cell (AEC)
apoptosis by a mitochondrial-regulated death pathway. To determine
whether mitochondrial-derived ROS are necessary for causing
asbestos-induced AEC apoptosis, we utilized A549-rho(omicron) cells
that lack mitochondrial DNA and a functional electron transport. As
expected, antimycin, which induces an oxidative stress by blocking
mitochondrial electron transport at complex III, increased
dichlorofluoroscein (DCF) fluorescence in A549 cells but not in
A549-rho(omicron) cells. Compared with A549 cells, rho(omicron) cells
have less asbestos-induced ROS production, as assessed by DCF
fluorescence, and reductions in total glutathione levels as well as
less caspase-9 activation and apoptosis, as assessed by TdT-mediated
dUTP nick end labeling staining and DNA fragmentation. A mitochondrial
anion channel inhibitor that prevents ROS release from the mitochondria
to the cytoplasm also blocked asbestos-induced A549 cell caspase-9
activation and apoptosis. Finally, a role for nonmitochondrial-derived
ROS with exposure to high levels of asbestos (50 microg/cm(2)) was
suggested by our findings that an iron chelator (phytic acid or
deferoxamine) or a free radical scavenger (sodium benzoate) provided
additional protection against asbestos-induced caspase-9 activation and
DNA fragmentation in rho(omicron) cells. We conclude that asbestos
fibers affect mitochondrial DNA and functional electron transport,
resulting in mitochondrial-derived ROS production that in turn mediates
AEC apoptosis. Nonmitochondrial-associated ROS may also contribute to
AEC apoptosis, particularly with high levels of asbestos exposure.

PMID: 14766669 [PubMed - indexed for MEDLINE]

----------------------------------------------------------------------------
----
Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore


DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Report this post to a moderator

[  Post Follow-up to this message ]

IanW wrote:
> Does anyone know what kind of nutrients promote repair of mitochondrial DN
A?
>
> Ian

Ian,  google authors "dr. bruce cohen and Dr. Deborah Gold"  or google
the title of their article :  "mitochondrial cytopathy in adults: what
we know thus far".  there are suggestions for several supplements and
vitamins and includes a suggestion for the old stand by
pednisone--though that is the only pharm drug included in their
recommendations.  best of luck

Report this post to a moderator

[  Post Follow-up to this message ]

" the precise source of ROS is unclear"

As I've been saying here for a while now, the source is clear.  The
evidence is abundant.  Just search pubmed.com for different
combinations of polyunsaturated, lipid peroxidation, arachidonic, ROS,
free radicals, linoleic, isoprostanes, etc.  You can add cancer,
diabetes, Alzheimer's, etc. and get more results that demonstrate the
connection.

Report this post to a moderator

[  Post Follow-up to this message ]

<mmlevy46@hotmail.com> wrote in message
news:1131758043.747182.225060@g14g2000cwa.googlegroups.com..

> Ian,  google authors "dr. bruce cohen and Dr. Deborah Gold"  or google
> the title of their article :  "mitochondrial cytopathy in adults: what
> we know thus far".  there are suggestions for several supplements and
> vitamins and includes a suggestion for the old stand by
> pednisone--though that is the only pharm drug included in their
> recommendations.  best of luck

thanks for the pointer. an interesting document:
http://www.ccjm.org/pdffiles/COHEN701.PDF

Ian

Report this post to a moderator

[  Post Follow-up to this message ]