On Thu, 10 Nov 2005 14:41:57 GMT, "Mr. Softy" <mrsofty@cinci.rr.com> wrote:

>Histamine causes peripheral vasodilatation and increases capillary
>permeability.

You are probably  right. I had said Histamine was vasoconstrictive. I got th
at
from a website discussing athsma. But there is a lot of conflicting
information floating around. Here is the source of my confusion:

Here is a quote from:
http://jap.physiology.org/cgi/content/full/83/5/1508
"We used histamine because it is a vasoconstrictive mediator of anaphylaxis"

Another from:
http://www.ncbi.nlm.nih.gov/entrez/..3&dopt=Abstract
"Histamine also caused both vasodilatation and vasoconstriction in ferret
lungs."

http://64.233.161.104/search?q=cach..l=en&lr=lang_en
" histamine, bradykinin and some prostaglandins released during the
inflammatory process cause powerful vasodilation."

One thing I may have missed in the discussion of athsma was the fact that th
e
cause is constriction of the bronchia muscles

http://www.medicinenet.com/chronic_..>
hattreatment
"Theophylline, like a beta agonist, relaxes the muscles surrounding the
airways but also prevents mast cells around the airways from releasing
bronchoconstricting chemicals such as histamine."

I tend to trust what I found at the NIH:
http://www.nlm.nih.gov/medlineplus/..icle/002338.htm
"Vasoconstriction may be slight or severe. It may result from disease,
medication, or psychological conditions. Medications that cause
vasoconstriction include:
* Antihistamines and decongestants .."


But in most cases, antihistamine was mentioned as helping treatment of
anorgasmia. Only a few said histamine had that effect.

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"Bob-S" <NSBob-S2@sbcglobal.net> wrote in message
news:dg99n1hj2so6oksev48qn29oai3etddflh@4ax.com..
> On Thu, 10 Nov 2005 14:41:57 GMT, "Mr. Softy" <mrsofty@cinci.rr.com>
wrote:
> 
>
> You are probably  right. I had said Histamine was vasoconstrictive. I got
that
> from a website discussing athsma. But there is a lot of conflicting
> information floating around. Here is the source of my confusion:

The key term in my response was "peripheral."  Your citations discussed
pulmonary physiology which is not peripheral.  There are often opposite
central and peripheral effects with drugs.  Beta agonists and blockers are
an example.

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On Fri, 11 Nov 2005 15:12:24 GMT, "Mr. Softy" <mrsofty@cinci.rr.com> wrote:

>The key term in my response was "peripheral."  Your citations discussed
>pulmonary physiology which is not peripheral.  There are often opposite
>central and peripheral effects with drugs.  Beta agonists and blockers are
>an example.
>

Thanks for the info. (I am still confused, but that is my normal state)

The issue relevant  to this group is whether antihistamines help in the
treatment of anorgasmia. The following seems to indicate that it does, thoug
h
the evidence is less than overwhelming:

http://www.dr-bob.org/babble/20030525/msgs/229290.html
"Fluoxetine-Induced Sexual Dysfunction Reversed by Loratadine"


http://64.233.161.104/search?q=cach..oratadine&hl=en
"  Open-label reports suggest that the following medications may improve
antidepressant-induced SD:

amantadine (100mg to 200mg/day);
bethanechol (10mg 30 minutes prior to sexual
activity);
cyproheptadine (4mg to 12 mg, one to two hours
prior to sexual activity, or 4mg to 12 mg/day);
ginkgo biloba (60mg to 900mg/day);
granisetron (1mg to 1.5mg, one to two hours prior
to sexual activity);
loratadine (2.5mg to 15mg/day);
methylphenidate (10mg to 40mg/day);
mianserin (7.5mg to 15mg/day); and
yohimbine (5.4mg three times daily).  "

** End of quote**

The article continues, saying that most of the above
" failed to support use of these medications."

It is interesting that loratadine was not mentioned as being one of the
disproved treatments.


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