Chang Q, He Y, Ni B, Feng K, Jiang Y, Jiang B.

Institute of Geriatrics, Chinese PLA General Hospital, Beijing 100853,
China.

OBJECTIVE: To investigate the risk of Alzheimer's disease (AD)
associated with life style, early exposure to magnetic fields, family
history of dementia and other risk factors. METHODS: We conducted a
case-control study among the inpatients of Chinese PLA General Hospital
in 2000 - 2003. Sixty-two AD cases and 124 controls were selected and
matched for age. Univariate and multivariate analyses were conducted
using logistic regression model. RESULTS: All subjects were males aged
66 to 102. In univariate analysis, lack of social activities, more
physical exercises, early exposure to magnetic fields, suffering from
negative life events and family history of dementia were statistically
different between two groups (P < 0.05). Multivariate analysis showed
that after adjusting for potential confounders, suffering from negative
life events, family histories of dementia increased the risk of AD with
odds ratio (OR) and 95% confidence interval (CI) 3.27 (1.53 - 6.97) and
5.78 (1.39 - 24.10). Early exposure to magnetic fields seemed a
possible risk factor for AD, with OR (95% CI) 2.49 (0.96 - 6.45). The
amount of social activities, cigarette smoking and history of cancers
were negatively correlated with AD and their ORs (95% CI) were 0.81
(0.72 - 0.92), 0.46 (0.21 - 1.00) and 0.31 (0.12 - 0.82) respectively.
CONCLUSION: The study demonstrated that suffering from negative life
events and family history of dementia were risk factors for AD, and the
early exposure to magnetic fields might also play a role.

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