<<snip>>
iron deposition resulting from hemochromatosis leads to Nephrogenic diabetes
insipidus
<<snip>>

Am J Kidney Dis. 2002 Aug;40(2):403-6.  Related Articles, Links


Nephrogenic diabetes insipidus associated with hemochromatosis.

Okumura A, Kondo K, Hirai C, Nishimura H, Tamai H, Kawarazaki F, Ichikawa M,
Mizuno M, Oiso Y, Yamamoto M.

Department of Endocrinology and Metabolism, Anjo Kosei Hospital, Anjo, Japan
.
okumura@kosei.anjo.aichi.jp

Although hemochromatosis is one of the most common genetic disorders in huma
ns,
the clinical information on iron-induced renal impairment is limited. We
describe the clinical features of nephrogenic diabetes insipidus (NDI) obser
ved
in a case of hemochromatosis. A 57-year-old diabetic man was admitted to the
hospital with a 6-month history of persistent polyuria, which had been
sustained after glycemic optimization with insulin therapy and resulted in
hepatic coma. Despite sufficient basal excretion of arginine vasopressin,
impaired urinary concentrating capacity was observed, which could not be
corrected by supraphysiologic doses of exogenous arginine vasopressin.
Histochemical investigations showed widely distributed iron deposition in
hepatocytes and moderately increased iron deposits in the tubular epithelium
 of
distal urinary tubules and collecting ducts, suggesting that iron deposition
resulting from hemochromatosis leads to NDI. This may be the first case repo
rt
of NDI associated with hemochromatosis in humans. More attention should be p
aid
to latent NDI as another complication of hemochromatosis. Copyright 2002 by 
the
National Kidney Foundation, Inc.

Publication Types:
Case Reports

PMID: 12148115 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------
------

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Tom

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>Subject: Nephrogenic diabetes insipidus / iron deposition
>From: ironjustice@aol.comdoe  (doe)
>Date: 10/4/2004 7:07 AM Mountain Daylight Time
>Message-id: <20041004090727.08241.00001361@mb-m10.aol.com>
>
><<snip>>
>iron deposition resulting from hemochromatosis leads to Nephrogenic diabete
s
>insipidus
><<snip>>
>
>Am J Kidney Dis. 2002 Aug;40(2):403-6.  Related Articles, Links
>
>
>Nephrogenic diabetes insipidus associated with hemochromatosis.
>
>Okumura A, Kondo K, Hirai C, Nishimura H, Tamai H, Kawarazaki F, Ichikawa M
,
>Mizuno M, Oiso Y, Yamamoto M.
>
>Department of Endocrinology and Metabolism, Anjo Kosei Hospital, Anjo, Japa
n.
>okumura@kosei.anjo.aichi.jp
>
>Although hemochromatosis is one of the most common genetic disorders in
>humans,
>the clinical information on iron-induced renal impairment is limited. We
>describe the clinical features of nephrogenic diabetes insipidus (NDI)
>observed
>in a case of hemochromatosis. A 57-year-old diabetic man was admitted to th
e
>hospital with a 6-month history of persistent polyuria, which had been
>sustained after glycemic optimization with insulin therapy and resulted in
>hepatic coma. Despite sufficient basal excretion of arginine vasopressin,
>impaired urinary concentrating capacity was observed, which could not be
>corrected by supraphysiologic doses of exogenous arginine vasopressin.
>Histochemical investigations showed widely distributed iron deposition in
>hepatocytes and moderately increased iron deposits in the tubular epitheliu
m
>of
>distal urinary tubules and collecting ducts, suggesting that iron depositio
n
>resulting from hemochromatosis leads to NDI. This may be the first case
>report
>of NDI associated with hemochromatosis in humans. More attention should be
>paid
>to latent NDI as another complication of hemochromatosis. Copyright 2002 by
>the
>National Kidney Foundation, Inc.
>
>Publication Types:
>Case Reports
>
>PMID: 12148115 [PubMed - indexed for MEDLINE]
>
>--------------------------------------------------------------------------
>------

http://tinyurl.com/6szsc

>
>Who loves ya.
>Tom


Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

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[  Post Follow-up to this message ]

>Subject: Nephrogenic diabetes insipidus / iron deposition
>From: ironjustice@aol.comdoe  (doe)
>Date: 10/4/2004 7:07 AM Mountain Daylight Time
>Message-id: <20041004090727.08241.00001361@mb-m10.aol.com>
>
><<snip>>
>iron deposition resulting from hemochromatosis leads to Nephrogenic diabete
s
>insipidus
><<snip>>
>
>Am J Kidney Dis. 2002 Aug;40(2):403-6.  Related Articles, Links
>
>
>Nephrogenic diabetes insipidus associated with hemochromatosis.
>
>Okumura A, Kondo K, Hirai C, Nishimura H, Tamai H, Kawarazaki F, Ichikawa M
,
>Mizuno M, Oiso Y, Yamamoto M.
>
>Department of Endocrinology and Metabolism, Anjo Kosei Hospital, Anjo, Japa
n.
>okumura@kosei.anjo.aichi.jp
>
>Although hemochromatosis is one of the most common genetic disorders in
>humans,
>the clinical information on iron-induced renal impairment is limited. We
>describe the clinical features of nephrogenic diabetes insipidus (NDI)
>observed
>in a case of hemochromatosis. A 57-year-old diabetic man was admitted to th
e
>hospital with a 6-month history of persistent polyuria, which had been
>sustained after glycemic optimization with insulin therapy and resulted in
>hepatic coma. Despite sufficient basal excretion of arginine vasopressin,
>impaired urinary concentrating capacity was observed, which could not be
>corrected by supraphysiologic doses of exogenous arginine vasopressin.
>Histochemical investigations showed widely distributed iron deposition in
>hepatocytes and moderately increased iron deposits in the tubular epitheliu
m
>of
>distal urinary tubules and collecting ducts, suggesting that iron depositio
n
>resulting from hemochromatosis leads to NDI. This may be the first case
>report
>of NDI associated with hemochromatosis in humans. More attention should be
>paid
>to latent NDI as another complication of hemochromatosis. Copyright 2002 by
>the
>National Kidney Foundation, Inc.
>
>Publication Types:
>Case Reports
>
>PMID: 12148115 [PubMed - indexed for MEDLINE]
>
>--------------------------------------------------------------------------
>------

http://tinyurl.com/6szsc

>
>Who loves ya.
>Tom


Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

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[  Post Follow-up to this message ]