| ironjustice@aol.com 2005-09-24, 2:41 pm |
| Urine biochemical markers of early renal dysfunction are associated
with iron overload in beta-thalassaemia.
Koliakos G, Papachristou F, Koussi A, Perifanis V, Tsatra I, Souliou E,
Athanasiou M
Clin Lab Haematol. 2003 Apr ; 25(2): 105-9
Renal dysfunction in thalassemia patients can be attributed to chronic
anemia, and iron overload as well as to desferioxamine (DFO) toxicity.
We analyzed the urine of 91 well-maintained homozygous beta-thalassemia
patients, with no evidence of renal disease, for early evidence of
kidney dysfunction by means of electrophoresis and quantitative
biochemical tests. Measurement of liver magnetic resonance imaging
(MRI) T2 values and serum ferritin concentration was used to estimate
iron overload. In 55 of the 91 patients, urine analysis indicated signs
of tubular dysfunction. The urine concentration of albumin and beta
2-microglobulin, as well as the activity of
N-acetyl-beta-D-glucosaminidase (NAG), correlated positively with serum
ferritin concentration and liver iron deposition, as detected by MRI T2
values. This suggested that the cause of renal dysfunction in
homozygous beta-thalassemia is iron overload. On the other hand, the
same urine markers did not correlate with age, indicating that chronic
anemia or desferrioxamine (DFO) treatment are not related to renal
dysfunction in thalassemia.
Abstract =B7 PubMed =B7 FullText =B7 SFX =B7 GS =B7 Order =B7 Clip =B7
Citation =B7 BibTeX =B7 Related =B7 TouchGraph =B7 References =B7 Tag
tags: annotation:
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
|