| ironjustice@aol.com 2005-11-30, 10:59 am |
| 1: Clin Chim Acta. 2005 May;355(1-2):91-6. Related Articles, Links
Reduction of urinary thiols in nephrotic syndrome--a possible effect of
free iron.
Sinha I, Ghosh S, Dey P, Jacob J, Banerjee D.
Department of Biochemistry, Kasturba Medical College, Manipal-576104,
Karnataka State, India.
BACKGROUND: Albumin is a potent antioxidant as it chelates transitional
metals and contains antioxidants like thiol and bilirubin. In neprotic
syndrome, the defining parameter is proteinuria with hypoalbuminemia.
Therefore albuminuria in nephrotic syndrome may increase toxic
transitional metal ions and also can cause loss of albumin associated
antioxidants causing oxidative stress to the individual. METHODS: We
investigated this possibility and estimated some markers of oxidative
stress in 20 nephrotic syndrome patients and healthy controls along
with urinary thiols, urinary bilirubin and plasma free iron in both
cases and in the controls. RESULT: We found oxidative stress in 20
nephrotic syndrome patients and the markers of oxidative stress
correlated significantly with proteinuria, but the urine of nephrotic
syndrome patients (28.33+/-4.2 micromol/g creatinine)contained
significantly less thiols compared to the healthy controls
(88.45+/-10.6 micromol/g creatinine) and no biliribin. The patients
plasma also showed free iron (0.7+/-0.05 micromol/l), a parameter
undetectable in the healthy controls. CONCLUSION: We suggest that
oxidative stress and presence of free iron in the patients were
responsible for less thioluria and no bilirubinuria. A detailed study
of oxidative biology in a large cohort of nephrotic syndrome patients
is necessary to confirm the presence of free iron as appropriate
chelation of free iron may benefit the long-term prognosis of the
disease.
PMID: 15820482 [PubMed - indexed for MEDLINE]
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