|
| Ren Fail. 2004 Nov;26(6):663-72. Related Articles, Links
Elevated cardiac troponin T in hemodialysis patients receiving more intravenous
iron sucrose.
Guz G, Sahinarslan A, Dhondt AW, Bagdatoglu O, Kavutcu M, Reis KA, Yalcin R,
Bali M, Sindel S.
Department of Nephrology, Gazi university Faculty of Medicine, Ankara, Turkey.
galip_guz@hotmail.com
Elevated cardiac troponin T (cTnT) has been associated with shorter survival in
hemodialysis patients. Moreover, intravenous (IV) iron treatment has been held
responsible for oxidative stress and accelerated atherosclerosis in these
patients. In the present study, we investigated the relationship between cTnT
concentration, IV iron treatment, and parameters of iron status. In addition,
parameters of oxidative stress, inflammation, and atherosclerosis were
evaluated. Predialysis blood samples of 78 chronic hemodialysis patients were
analyzed for cTnT, malondialdehyde, creatine kinase (CK), and CK-isoenzyme MB
(CK-MB). In addition, the mean value of predialysis serum samples collected
during the last year, were considered for homocysteine, ferritin, iron, iron
binding capacity, blood cell counts, blood urea nitrogen, creatinine, albumin,
erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), calcium,
phosphate, iPTH, cholesterol, and triglyceride. The quantity of IV iron sucrose
administered during the last two years was counted from the patients' files.
Echocardiography, all events related to ischemic heart disease, and urine
volume were also recorded. Elevated cTnT levels (> or =0.10 ng/mL) were found
in 18 patients (23.1%). The amount of iron administered was 2264+/-1871 mg with
a range 0-7000 mg. Patients with elevated cTnT levels received more IV iron
than those with normal cTnT (3692+/-1771 vs. 1761+/-1595 mg, p<0.001). The
serum ferritin level was higher in patients with elevated cTnT (median levels;
477 vs. 288 ng/mL; P<0.05). Patients with elevated cTnT were longer on dialysis
compared to those with normal levels (median times; 35.5 vs. 15 months, P<0.01)
and regression analysis identified the amount of administered iron as an
independent factor for elevated cTnT (P<0.01). Intravenous iron treatment and
high ferritin concentration are related to high cTnT level, which has
previously been incriminated as a survival marker in hemodialysis patients.
PMID: 15600258 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
|
|