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| Clin Chim Acta. 2004 Dec;350(1-2):57-63. Related Articles, Links
Oxidative stress in urogenital tuberculosis patients: a predisposing factor for
renal stone formation-amelioration by vitamin E supplementation.
Srinivasan S, Pragasam V, Jenita X, Kalaiselvi P, Muthu V, Varalakshmi P.
Department of Medical Biochemistry, Dr. A.L. Mudaliar Post Graduate Institute
of Basic Medical Sciences, university of Madras, Taramani, Chennai 600 113,
India.
BACKGROUND: Previous studies have shown that urogenital tuberculosis (GuTb)
patients treated or untreated with regular anti-Tb regimen excrete
comparatively high levels of urinary stone forming constituents than normal
subjects. Enhanced oxidative stress is also considered as a prime factor that
accelerates urolithiasis. The present study was aimed to determine antioxidant
status and lipid peroxidation of these individuals in order to assess their
risk for kidney stone formation. METHODS: GuTb patients and age-matched normal
subjects were divided into four groups: I: normal subjects (n=60), II: GuTb
patients a day before treatment (n=72), III: GuTb patients after treatment with
isoniazid (300 mg), rifampicin (450 mg) and pyrazinamide (1.5 g) per day for 60
days (n=42), and IV: GuTb patients supplemented with vitamin E (200 mg/day)
along with regular chemotherapy for 60 days (n=30). Blood was collected and
tested for various markers of oxidative stress. RESULTS: Increased levels of
lipid peroxidation, protein carbonyls (PCO), advanced oxidative protein
products (AOPP) and reduced antioxidant defenses by impairment in enzyme
activities like superoxide dismutase, catalase, glutathione peroxidase, reduced
glutathione and decreased plasma concentrations of non enzymatic antioxidants
like vitamins C and E were observed in the treated and untreated GuTb patients.
CONCLUSIONS: These biochemical disparities may lead to membrane disintegrity,
which is favorable for retention of mirolithis. Advocation of vitamin E
enhanced the antioxidant status of the plasma, thereby preventing membrane
injury, consequently reducing the risk of stone formation in urogenital
tuberculosis patients, who were treated with their routine anti-tuberculosis
drug regimen.
PMID: 15530460 [PubMed - in process]
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