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| Indian J Exp Biol. 2004 Feb;42(2):179-85. Related Articles, Links
Antiinflammatory and antiulcer activities of phytic acid in rats.
Sudheer Kumar M, Sridhar Reddy B, Kiran Babu S, Bhilegaonkar PM, Shirwaikar A,
Unnikrishnan MK.
Department of Pharmacology, college of Pharmaceutical Sciences, Manipal 576
119, India.
Maximum antiinflammatory activity of phytic acid (PA) was seen at an oral dose
of 150 mg/kg in the carrageenan induced rat paw edema model. Although PA showed
ability to prevent denaturation of proteins, it showed less antiinflammatory
activity than ibuprofen. Ability of PA to bring down thermal denaturation of
proteins might be a contributing factor in the mechanism of action against
inflammation. PA, at all the doses tested, showed significant protection from
ulcers induced by ibuprofen, ethanol and cold stress, with a maximum activity
at 150 mg/kg. There was a significant increase in gastric tissue
malondialdehyde levels in ethanol treated rats but these levels decreased
following PA pretreatment. Moreover, pretreatment with PA significantly
inhibited various effects of ethanol on gastric mucosa, such as, reduction in
the concentration of nonprotein sulfhydryl groups, necrosis, erosions,
congestion and hemorrhage. These results suggested that gastro-protective
effect of PA could be mediated by its antioxidant activity and cytoprotection
of gastric mucosa.
PMID: 15282951 [PubMed - in process]
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