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Home > Archive > Lasik Eyes Surgery > October 2006 > Lasik damage can be objectively measured in every eye! Bowman damage, interface partic
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Lasik damage can be objectively measured in every eye! Bowman damage, interface partic
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| New studies show LASIK damage to the eye at 100%.:
Excerpts from full text:
Permanent haze at the flap margin, 100% rate of interface particles,
100%
rate of Bowman's microfolds, 100% permanent interface scar "permanently
altered from normal", 100% epithelial thickening, acutely and
chronically
reduced keratocytes, some corneas had "empty spaces" in the interface
wound
"filled with foreign material suspicious for plastic particles",
necrotic
epithelial cells in the interface, chronically vacuolated keratocytes
in the
interface, corneal nerves MIA, and the flap does not fit to the
underlying
stroma.
Here's the abstract:
Ophthalmology. 2005 Apr;112(4):634-44.
Ex vivo confocal microscopy of human LASIK corneas with histologic and
ultrastructural correlation.
Dawson DG, Holley GP, Geroski DH, Waring GO 3rd, Grossniklaus HE,
Edelhauser
HF.
Department of Ophthalmology, Emory university School of Medicine,
Atlanta,
Georgia, USA.
OBJECTIVE: To perform confocal microscopy on postmortem human LASIK
corneas
and correlate these findings to histologic and ultrastructure
evaluations.
DESIGN: Prospective, consecutive, observational case series.
PARTICIPANTS:
Ninety postmortem LASIK corneas (47 patients) were evaluated for
histopathology, of which 22 consecutive corneas (12 patients) were also
evaluated by confocal microscopy. Six normal corneas (3 patients)
served as
controls. METHODS: This observational case series involving 22 corneas
from
12 patients with postoperative intervals from 1 month to 6.5 years
after
LASIK surgery were collected. The corneas were mounted in an artificial
anterior chamber and perfused with balanced salt solution before
confocal
microscopy was performed on the center of the cornea. The corneas were
then
bisected and processed for light and transmission electron microscopy.
RESULTS: Confocal microscopy, along with histologic and ultrastructural
correlations, demonstrated that the most prevalent alterations in the
centers of LASIK corneas were a slightly thickened epithelium caused by
focal basal epithelial cell hypertrophic modifications, random
undulations
in Bowman's layer over the flap surface, and a variably thick
hypocellular
primitive stromal interface scar. By using confocal microscopy, the
interface wound was easily identified in 100% of the cases because
numerous
brightly reflective interface particles were always present in the
hypocellular primitive stromal scar. These particles were found
primarily to
consist of organic cellular constituents, some of which were transient
in
nature. CONCLUSION: After LASIK, active stromal wound healing in the
central
cornea results in the production of a hypocellular primitive stromal
scar,
whereas secondary tissue adjustments seem to cause the Bowman's layer
undulations and the subsequent epithelial cell modifications. Most of
the
interface particles revealed by confocal microscopy in the region of
the
stromal scar are organic in nature and presumably innocuous to the
cornea.
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