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Home > Archive > Lasik Eyes Surgery > April 2005 > Permanent pathologic changes present in all post-LASIK corneas
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Permanent pathologic changes present in all post-LASIK corneas
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| Pathologic means sick, folks. Post-LASIK corneas are sick. All of them.
Pathologic Findings in Postmortem Corneas After Successful Laser In Situ
Keratomileusis.
Cornea. 24(1):92-102, January 2005.
Kramer, Theresa R MD, MBA; Chuckpaiwong, Varintorn MD; Dawson, Daniel G MD;
L'Hernault, Nancy; Grossniklaus, Hans E MD; Edelhauser, Henry F PHD
Abstract:
Purpose: To examine the histologic and ultrastructural features of human
corneas after successful laser in situ keratomileusis (LASIK).
Methods: Corneas from 48 eyes of 25 postmortem patients were processed for
histology and transmission electron microscopy (TEM). The 25 patients had
LASIK between 3 months and 7 years prior to death. Evaluation of all 5
layers of the cornea and the LASIK flap interface region was done using
routine histology, periodic acid-Schiff (PAS)-stained specimens, toluidine
blue-stained thick sections, and TEM.
Results: In patients for whom visual acuity was known, the first
postoperative day uncorrected visual acuity was 20/15 to 20/30. In patients
for whom clinical records were available, the postoperative corneal
topography was normal and clinical examination showed a semicircular ring of
haze at the wound margin of the LASIK flap. Histologically, the LASIK flap
measured, on average, 142.7 [mu]m (range, 100-200). A spectrum of abnormal
histopathologic and ultrastructural findings was present in all corneas.
Findings at the flap surface included elongated basal epithelial cells,
epithelial hyperplasia, thickening and undulations of the epithelial
basement membrane (EBM), and undulations of Bowman's layer. Findings in or
adjacent to the wound included collagen lamellar disarray; activated
keratocytes; quiescent keratocytes with small vacuoles; epithelial ingrowth;
eosinophilic deposits; PAS-positive, electron-dense granular material
interspersed with randomly ordered collagen fibrils; increased spacing
between collagen fibrils; and widely spaced banded collagen. There was no
observable correlation between postoperative intervals and the severity or
type of pathologic change except for the accumulation the electron-dense
granular material.
Conclusions: Permanent pathologic changes were present in all post-LASIK
corneas. These changes were most prevalent in the lamellar interface wound.
These changes along with other pathologic alterations in post-LASIK corneas
may change the functionality of the cornea after LASIK.
(C) 2005 Lippincott Williams & Wilkins, Inc.
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| serebel 2005-04-14, 8:42 am |
| Casey, did Sandy hire you to print this garbage ? Don't know about
you, but I'm enjoying my pathologic corneas.
SErebel
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