| ironjustice@aol.com 2006-09-30, 4:29 pm |
| Treatment for hypercholesterolemia
Document Type and Number: United States Patent 5231090
Link to this Page: http://www.freepatentsonline.com/5231090.html
Abstract: The present invention relates to a method of modifying serum
cholesterol levels in a mammal by topically administering to the skin
of the mammal an effective amount of at least one phospholipid.
Atherosclerosis, and related complications, can be treated, or
prevented, using the present method
EXAMPLE III
BK, a 39 year old man who was in apparent good health although slightly
overweight, became concerned about his elevated serum cholesterol
level. Fasting blood samples were taken in three consecutive weeks, and
the results showed serum cholesterol consistently above 290 mg/dl. He
was given the following instruction:
1) Take a hot shower in the evening, and dry your skin with a towel.
2) Apply the solution given to you to your skin and rub it in well, to
cover your legs, arms, the abdomen and the back. Use all the solution,
and spread it to cover all your body.
3) To enhance percutaneous absorption, wrap your legs with a thin
plastic film, e.g. Saran Wrap, and fix the wrapping with a tape or an
Ace bandage.
4) Rest or take a nap, and wait for at least 2 hours before washing off
the unabsorbed material on your skin.
The solution given him for each application was 12.5 ml of Formula
M-23-90 which has the following composition:
______________________________________
Formula M-23-9 (Total volume 78 ml)
______________________________________
Soy lecithin 25 gm
BHT 0.2 gm
Ethanol 25 ml
Isopropanol 18 ml
Distilled water
18 ml
______________________________________
BK returned each week or 10 days for analysis of fasting blood lipid
profile. His serum cholesterol and low density lipoproteins showed
definite reductions after each treatment with Formula M-23-90. He
reported no undesirable effects. A summary of his lipid profiles is
shown in the following table
______________________________________
BK LIPID PROFILE
(mg/dl of serum)
Day SC TG HDL VLDL LDL
______________________________________
1 292 356 34 98 160
9 295 311 42 108 145
16 294 167 40 56 198
16 Treatment with Formula M-23-90
24 262 263 35 52 175
24 Treatment with Formula M-23-90
35 242 248 37 81 124
35 Treatment with Formula M-23-90
42 236 257 38 72 126
______________________________________
Abbreviations are: SC, serum cholesterol; TG, serum triglycerides; HDL,
high density lipoproteins; VLDL, very low density lipoproteins; LDL,
low density lipoproteins.
The entire contents of all references cited hereinabove are hereby
incorporated by reference.
While the foregoing invention has been described in some detail for
purposes of clarity and understanding, it will be clear to one skilled
in the art from a reading of this disclosure that various changes in
form and detail can be made without departing from the true scope of
the invention.
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