| ironjustice@aol.com 2006-09-25, 2:35 am |
| <<snip>>
Supplementary omega-3 FA significantly reduces the level of
pro-inflammatory and immunosuppressive PGE(2) levels in Ultraviolet
B-irradiated human skin.
<<snip>>
Cancer Detect Prev. 2006;30(3):224-32. Epub 2006 Jul 26. Links
The potential of omega-3 fatty acids in the prevention of non-melanoma
skin cancer.Black HS, Rhodes LE.
Department of Dermatology, Baylor college of Medicine, Houston, TX
77030, USA. hblack@bcm.tmc.edu
In toto, there is strong circumstantial evidence from both experimental
and clinical studies to support a role for omega-3 FA in the prevention
of non-melanoma skin cancer (NMSC). In experimental animal studies
there is direct evidence that dietary omega-3 FA inhibits ultraviolet
radiation (UVR) carcinogenic expression, with regard to both increased
tumor latent period and reduced tumor multiplicity. Equivalent levels
of omega-6 FA increase UVR carcinogenic expression. Dietary omega-3 FA
dramatically reduces the plasma and cutaneous pro-inflammatory and
immunosuppressive PGE(2) levels in mice. Dietary omega-6 FA increases
prostaglandin E synthase type 2 (PGE(2)) level. Dietary omega-3 FA
significantly reduces the inflammatory response and sustains, or
enhances, the delayed type hypersensitivity immune response in mice
when compared to an equivalent dietary level of omega-6 FA.
Supplementary omega-3 FA significantly increases the UVR-mediated
erythema threshold in humans. Supplementary omega-3 FA significantly
reduces the level of pro-inflammatory and immunosuppressive PGE(2)
levels in Ultraviolet B-irradiated human skin.
PMID: 16872755 [PubMed - in process]
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