| ironjustice@aol.com 2006-09-13, 9:27 pm |
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Review Article
Journal of Cosmetic Dermatology. 5(3):210-217, September 2006.
Kitazawa, M PhD; Iwasaki, K PhD; Sakamoto, K PhD
Abstract:
Summary: For years, cosmetic ingredients for anti-aging treatments have
attracted consumers. Skin aging is accelerated by reactive oxygen
species (ROS), generated by exposure to solar ultraviolet radiation
(UVR), in a process known as photoaging. Because cutaneous iron
catalyses ROS generation, it is thought to play a key role in
photoaging. Iron is essential to almost all forms of life. However,
excess iron is potentially toxic as its catalytic activity induces the
generation of ROS. Iron-catalysed ROS generation is involved in
numerous pathological conditions, including cutaneous damage.
When skin is directly exposed to UVR, cutaneous intracellular catalytic
iron levels increase because of the release of iron from iron-binding
proteins such as ferritin. Consequently, the subsequent ROS generation
may overwhelm cutaneous defense systems such as the cellular iron
sequestration and ROS scavenging capacity.
The harmful role of excess cutaneous iron implies that there may be a
potential for topical iron chelator treatments. We now consider
cutaneous photodamage skin photoaging as the result of iron-catalysed
ROS generation and discuss preventative strategies based on iron
chelators.
Copyright (C) 2006 Blackwell Publishing Ltd.
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