Lupus Support - Sunlight skin protection / quercetin / iron chelation

Author

Sunlight skin protection / quercetin / iron chelation

ironjustice@aol.com

2006-09-09, 4:29 pm

In vitro evaluation of quercetin cutaneous absorption from topical
formulations and its functional stability by antioxidant activity.
Casagrande R, Georgetti SR, Verri WA, Borin MF, Lopez RF, Fonseca MJ
Int J Pharm. 2006 Aug 14;

Recently, it was demonstrated that two different formulations
containing quercetin inhibit the UVB-induced cutaneous oxidative stress
and inflammation. Therefore, in the present study it was evaluated the
functional stability of those formulations by the antioxidant activity,
the release of quercetin from the formulations, and its skin retention
using modified Franz diffusion cells. Both formulations tested ((1)
non-ionic emulsion with high lipid content and (2) anionic emulsion
with low lipid content) remained functionally (hydrogen-donating
ability) stable during 180 days. Furthermore, quercetin was released
from both formulations as determined using nitrocellulose membrane. In
vitro antioxidant activity of retained quercetin into the skin was
observed for both formulations as detected by the inhibition of
malondialdehyde formation. The effect of quercetin retention was
time-dependent for formulation 1. Concluding, this study demonstrates
that quercetin remains functionally stable in formulations, and
measuring the antioxidant activity is an efficient approach to evaluate
quercetin skin retention with minimal interference of the tissue
products. Furthermore, the present results on skin retention explain
the previous study on quercetin in vivo activities, and together, these
data suggest that formulations containing quercetin may be used as
topical active products to control UVB-mediated oxidative damage of the
skin.

---------------------------------------------------------------------------=
-----

J=2E Agric. Food Chem., 54 (17), 6343 -6351, 2006. 10.1021/jf060986h
S0021-8561(06)00986-1
Web Release Date: August 2, 2006

Copyright =A9 2006 American Chemical Society
Iron Chelation by the Powerful Antioxidant Flavonoid Quercetin

Monica Leopoldini, Nino Russo,* Sandro Chiodo, and Marirosa Toscano

Dipartimento di Chimica and Centro di Calcolo ad Alte Prestazioni per
Elaborazioni Parallele e Distribuite-Centro d'Eccellenza MIUR,
Universit=E0 della Calabria, I-87030 Arcavacata di Rende (CS), Italy

Received for review April 7, 2006. Revised manuscript received June 16,
2006. Accepted June 26, 2006. Financial support from the university of
Calabria and Regione Calabria (POR Calabria 2000/2006 misura 3.16. d,
progetto VACAVISS) is gratefully acknowledged.

Abstract:

Chelation of the bare and hydrated iron(II) cation by quercetin has
been investigated at the DF/B3LYP level in the gas phase. Several
complexed species arising from neutral and anionic forms of the ligand
have been taken into account. Both 1:1 and 1:2 metal/flavonoid
stoichiometries have been considered. Results indicate that among the
potential sites of chelation present on quercetin, the oxygen atoms
belonging to the 3-hydroxy and 4-oxo, and to the 5-hydroxy and 4-oxo
groups, are the preferred ones. Time-dependent density functional
theory (TDDFT) calculations, used to reproduce the electronic UV-vis
spectra of isolated quercetin and its complexes with Fe2+, were also
performed in methanol and dimethylsulfoxide.

Keywords: Quercetin; iron(II); complexation; antioxidants

---------------------------------------------------------------------------=
-----

UNIVERSITY OF FLORIDA AND PROCTER & GAMBLE TEAM UP AGAINST SKIN CANCER

Feb. 11, 2002
Contact Information

--------------------------------------------------------------------------

------

GAINESVILLE, Fla. --- The university of Florida and Procter & Gamble
today
announced they have joined forces to advance research on
Photoprotective Iron
Chelator Technology, which was developed by P&G and shows promise for
preventing or reducing the harmful effects of the sun, particularly
skin
cancer.

Preliminary research has shown that, in combination with the
appropriate
sunscreen, Photoprotective Iron Chelator Technology, or PICT, may have
the
potential to decrease the number of individuals who develop skin cancer
by
greatly delaying or preventing tumor onset. It may also reduce the
number of
tumors in those who do develop skin cancer. The safety and efficacy of
PICT
must be demonstrated in clinical trials, and the product will
ultimately
require review and approval by the Food and Drug Administration.

"When ultraviolet light penetrates the skin it forms oxygen radicals
which,
in the presence of iron, can cause skin wrinkling, sunburn and
cancer," said
Don Bissett, a P&G skin care research fellow, whose more than six years
of
research resulted in PICT. "The P&G iron chelator binds to iron so
that it
can no longer cause this reaction."

P&G and the university of Florida Research Foundation have formed a new
company
called ChelaDerm to continue the development of the technology and seek
FDA
approval. P&G will contribute a royalty-free, exclusive license of the
PICT
patents to the new company, while the research foundation will
underwrite
independent clinical trials and provide ChelaDerm with access to UF
personnel
and resources through a management services contract. The research
foundation
is a private, not-for-profit support organization that facilitates the
transfer
of university technology from the laboratory to the marketplace.

PICT arose from P&G's substantial commitment to skin-care research.
Because
P&G is not able to devote resources to commercialize all of its more
than
27,000 patents, the company occasionally seeks partners to advance
technologies
that are not a strategic fit with its current product development
activities.
P&G markets 250 brands to five billion consumers in 130 countries and
invests
nearly $2 billion a year research and development.

Dr. Raymond Bergeron, a graduate research professor of medicinal
chemistry and
eminent scholar in drug development in the UF college of Pharmacy, is
one of
the world's leading experts on iron chelators. Bergeron has spent more
than two
decades studying iron chelators and is the author of numerous
publications on
the subject. His expertise in drug discovery and development led to the

company's decision to pursue a partnership with UF.

"2-furildioxime, or FDO, the active ingredient in PICT, in
combination with a
sunscreening agent, has the potential to offer both improved prevention
of
sunburn and a unique means of delaying or preventing the development of
skin
cancer," Bergeron said, adding that more than a million Americans
develop
skins cancer annually.

"Consumers have become increasingly aware of the dangers of
unprotected
exposure to ultraviolet radiation," said Tom Minnick, P&G's
director of
external business development and president of ChelaDerm. "We're
excited to
work with the UF Research Foundation in an effort to develop a new sun
care
product to address both the short-term effects of sun exposure, such as

sunburn, as well as the long-term effects, including skin cancer risk
and
premature aging of the skin."

Initial clinical trials will confirm the safety of FDO and determine
what
combinations of FDO and sunscreens are most effective in preventing
skin
damage. The trials initially will focus on individuals with the
autoimmune
disease lupus, who are extremely sensitive to the sun.

"ChelaDerm offers an unprecedented opportunity for the university of
Florida
and P&G to pool their extensive intellectual and scientific resources
in an
effort to alleviate the negative impact of ultraviolet sun exposure,"
said
Win Phillips, UF's vice president for research. "Facilitating the
transfer
of this kind of technology from the laboratory to the marketplace in a
timely
manner is exactly what the UF Research Foundation was established to
do."

-30-

--------------------------------------------------------------------------

------
Sources: Joseph Kays, (352) 392-8229, joek...@ufl.edu
Caroline Charles, Northlich PR for P&G, (513) 762-5571
--------------------------------------------------------------------------

------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING=20
http://tinyurl.com/zk9fk

Marie Davis

2006-09-09, 9:28 pm

Ok, I got just one question. Can someone tell me what all this means
in layman's terms? And what the heck is up with ironjustice anyway.
He's really really bored and has just way to much time on his hands!

Marie

On 9 Sep 2006 09:43:22 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:

>In vitro evaluation of quercetin cutaneous absorption from topical
>formulations and its functional stability by antioxidant activity.
>Casagrande R, Georgetti SR, Verri WA, Borin MF, Lopez RF, Fonseca MJ
>Int J Pharm. 2006 Aug 14;
>
>Recently, it was demonstrated that two different formulations
>containing quercetin inhibit the UVB-induced cutaneous oxidative stress
>and inflammation. Therefore, in the present study it was evaluated the
>functional stability of those formulations by the antioxidant activity,
>the release of quercetin from the formulations, and its skin retention
>using modified Franz diffusion cells. Both formulations tested ((1)
>non-ionic emulsion with high lipid content and (2) anionic emulsion
>with low lipid content) remained functionally (hydrogen-donating
>ability) stable during 180 days. Furthermore, quercetin was released
>from both formulations as determined using nitrocellulose membrane. In
>vitro antioxidant activity of retained quercetin into the skin was
>observed for both formulations as detected by the inhibition of
>malondialdehyde formation. The effect of quercetin retention was
>time-dependent for formulation 1. Concluding, this study demonstrates
>that quercetin remains functionally stable in formulations, and
>measuring the antioxidant activity is an efficient approach to evaluate
>quercetin skin retention with minimal interference of the tissue
>products. Furthermore, the present results on skin retention explain
>the previous study on quercetin in vivo activities, and together, these
>data suggest that formulations containing quercetin may be used as
>topical active products to control UVB-mediated oxidative damage of the
>skin.
>
>
>--------------------------------------------------------------------------------
>
>J. Agric. Food Chem., 54 (17), 6343 -6351, 2006. 10.1021/jf060986h
>S0021-8561(06)00986-1
>Web Release Date: August 2, 2006
>
>Copyright © 2006 American Chemical Society
>Iron Chelation by the Powerful Antioxidant Flavonoid Quercetin
>
>Monica Leopoldini, Nino Russo,* Sandro Chiodo, and Marirosa Toscano
>
>Dipartimento di Chimica and Centro di Calcolo ad Alte Prestazioni per
>Elaborazioni Parallele e Distribuite-Centro d'Eccellenza MIUR,
>Università della Calabria, I-87030 Arcavacata di Rende (CS), Italy
>
>Received for review April 7, 2006. Revised manuscript received June 16,
>2006. Accepted June 26, 2006. Financial support from the university of
>Calabria and Regione Calabria (POR Calabria 2000/2006 misura 3.16. d,
>progetto VACAVISS) is gratefully acknowledged.
>
>Abstract:
>
>Chelation of the bare and hydrated iron(II) cation by quercetin has
>been investigated at the DF/B3LYP level in the gas phase. Several
>complexed species arising from neutral and anionic forms of the ligand
>have been taken into account. Both 1:1 and 1:2 metal/flavonoid
>stoichiometries have been considered. Results indicate that among the
>potential sites of chelation present on quercetin, the oxygen atoms
>belonging to the 3-hydroxy and 4-oxo, and to the 5-hydroxy and 4-oxo
>groups, are the preferred ones. Time-dependent density functional
>theory (TDDFT) calculations, used to reproduce the electronic UV-vis
>spectra of isolated quercetin and its complexes with Fe2+, were also
>performed in methanol and dimethylsulfoxide.
>
>Keywords: Quercetin; iron(II); complexation; antioxidants
>
>
>--------------------------------------------------------------------------------
>
>
>UNIVERSITY OF FLORIDA AND PROCTER & GAMBLE TEAM UP AGAINST SKIN CANCER
>
>
>Feb. 11, 2002
>Contact Information
>
>
>--------------------------------------------------------------------------
>
>------
>
>
>GAINESVILLE, Fla. --- The university of Florida and Procter & Gamble
>today
>announced they have joined forces to advance research on
>Photoprotective Iron
>Chelator Technology, which was developed by P&G and shows promise for
>preventing or reducing the harmful effects of the sun, particularly
>skin
>cancer.
>
>
>Preliminary research has shown that, in combination with the
>appropriate
>sunscreen, Photoprotective Iron Chelator Technology, or PICT, may have
>the
>potential to decrease the number of individuals who develop skin cancer
>by
>greatly delaying or preventing tumor onset. It may also reduce the
>number of
>tumors in those who do develop skin cancer. The safety and efficacy of
>PICT
>must be demonstrated in clinical trials, and the product will
>ultimately
>require review and approval by the Food and Drug Administration.
>
>
>"When ultraviolet light penetrates the skin it forms oxygen radicals
>which,
>in the presence of iron, can cause skin wrinkling, sunburn and
>cancer," said
>Don Bissett, a P&G skin care research fellow, whose more than six years
>of
>research resulted in PICT. "The P&G iron chelator binds to iron so
>that it
>can no longer cause this reaction."
>
>
>P&G and the university of Florida Research Foundation have formed a new
>company
>called ChelaDerm to continue the development of the technology and seek
>FDA
>approval. P&G will contribute a royalty-free, exclusive license of the
>PICT
>patents to the new company, while the research foundation will
>underwrite
>independent clinical trials and provide ChelaDerm with access to UF
>personnel
>and resources through a management services contract. The research
>foundation
>is a private, not-for-profit support organization that facilitates the
>transfer
>of university technology from the laboratory to the marketplace.
>
>
>PICT arose from P&G's substantial commitment to skin-care research.
>Because
>P&G is not able to devote resources to commercialize all of its more
>than
>27,000 patents, the company occasionally seeks partners to advance
>technologies
>that are not a strategic fit with its current product development
>activities.
>P&G markets 250 brands to five billion consumers in 130 countries and
>invests
>nearly $2 billion a year research and development.
>
>
>Dr. Raymond Bergeron, a graduate research professor of medicinal
>chemistry and
>eminent scholar in drug development in the UF college of Pharmacy, is
>one of
>the world's leading experts on iron chelators. Bergeron has spent more
>than two
>decades studying iron chelators and is the author of numerous
>publications on
>the subject. His expertise in drug discovery and development led to the
>
>company's decision to pursue a partnership with UF.
>
>
>"2-furildioxime, or FDO, the active ingredient in PICT, in
>combination with a
>sunscreening agent, has the potential to offer both improved prevention
>of
>sunburn and a unique means of delaying or preventing the development of
>skin
>cancer," Bergeron said, adding that more than a million Americans
>develop
>skins cancer annually.
>
>
>"Consumers have become increasingly aware of the dangers of
>unprotected
>exposure to ultraviolet radiation," said Tom Minnick, P&G's
>director of
>external business development and president of ChelaDerm. "We're
>excited to
>work with the UF Research Foundation in an effort to develop a new sun
>care
>product to address both the short-term effects of sun exposure, such as
>
>sunburn, as well as the long-term effects, including skin cancer risk
>and
>premature aging of the skin."
>
>
>Initial clinical trials will confirm the safety of FDO and determine
>what
>combinations of FDO and sunscreens are most effective in preventing
>skin
>damage. The trials initially will focus on individuals with the
>autoimmune
>disease lupus, who are extremely sensitive to the sun.
>
>
>"ChelaDerm offers an unprecedented opportunity for the university of
>Florida
>and P&G to pool their extensive intellectual and scientific resources
>in an
>effort to alleviate the negative impact of ultraviolet sun exposure,"
>said
>Win Phillips, UF's vice president for research. "Facilitating the
>transfer
>of this kind of technology from the laboratory to the marketplace in a
>timely
>manner is exactly what the UF Research Foundation was established to
>do."
>
>
>-30-
>
>
>--------------------------------------------------------------------------
>
>------
>Sources: Joseph Kays, (352) 392-8229, joek...@ufl.edu
>Caroline Charles, Northlich PR for P&G, (513) 762-5571
>--------------------------------------------------------------------------
>
>------
>
>
>Who loves ya.
>Tom
>
>
>Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com
>
>
>Man Is A Herbivore!
>http://tinyurl.com/a3cc3
>
>
>DEAD PEOPLE WALKING
>http://tinyurl.com/zk9fk

Sherry

2006-09-10, 2:27 am

He is someone that most of us have on our blocked sender list or just
ignore. It seems that he posts on numerous boards and likes to keep things
stirred up. None of us pays any attention to what he has to say.

Hugs,
Sherry

patti

2006-09-10, 2:27 am

This is one of many groups that are totally into allopathic (natural)
care as opposed to medicine.
Coming from a medical background, I believe the two can live
harmoniously. Ive always felt a dr. who said stop all meds and go
natural was dangerous ans is one who says stop everything natural and
do only meds.
I stick with one who believes as I do that there are some things I can
do to help myself no medicine can touch. But I DO NOT miss my med
doses

Basically this is trying to sell a cream that will block uva rays.
There is a bunch of technical garbles BS in there that truly means
nothing.

Now that they have found this group, expect more. They took over
another group I am on.
Patti

On Sun, 10 Sep 2006 02:08:10 GMT, Marie Davis
<bearsohmy2001@verizon.net> wrote:
[vbcol=seagreen]
>Ok, I got just one question. Can someone tell me what all this means
>in layman's terms? And what the heck is up with ironjustice anyway.
>He's really really bored and has just way to much time on his hands!
>
>Marie
>
>
>On 9 Sep 2006 09:43:22 -0700, "ironjustice@aol.com"
><ironjustice@aol.com> wrote:
>

ironjustice@aol.com

2006-09-10, 4:27 pm

>>Marie wrote:

Ok, I got just one question. Can someone tell me what all this means
in layman's terms? <<
[vbcol=seagreen]

Coming from a medical background <<

And you will notice .. patti .. didn't answer the .. question .. ?

Because .. ?
Because .. ?

She .. simply .. doesn't .. know .. or doesn't .. care ..

One way or the other .. not .. much .. use .. on THIS .. 'particular'
... thread ..

That would be .. 'evidence based' ..

'They' are .. TARGETING the iron in the skin of those with autoimmune
disease .. lupus .. and the other articles speak to the finding of iron
in the skin reflecting the amount of iron IN the body
.. and since the elevated levels of iron in the skin of lupus is ..
KNOWN .. then one can dedeuce .. then .. the **body** levels of iron
in those with lupus .. is .. ALSO .. elevated ..

Pretty .. straight .. forward ..

This story from .. yesterday .. explains it ..

http://news.bbc.co.uk/2/hi/health/5326474.stm

Suncream that can 'heal' sunburn

The lotion is undergoing lab testing
UK scientists say they have developed a sunscreen that will actively
repair sunburnt skin and may even help prevent skin cancer.
Like conventional suncreams, the lotion filters the sun's harmful rays.

But an extra ingredient means it also helps mop up the free iron
released when skin burns, the Bath university team found.

This reduces inflammation, pain and prevents the build up of
cancer-causing free radicals triggered by sunlight.

Many forms of cancer are thought to be the result of reactions
between free radicals and DNA

Lead researcher Dr Charareh Pourzand

The new ingredient - called a chelator - is light-responsive, meaning
it only becomes active when it is exposed to UV radiation in sunlight.

This should avoid any side effects that might result from long-term
exposure to the active form of the drug, the authors told the Journal
of Investigative Dermatology.

Dr Charareh Pourzand, along with colleagues at Nottingham University,
is currently testing prototypes of the ingredient in the laboratory,
but expects to begin human trials in the next two to three years.

Sun damage

She said: "When skin is exposed to high doses of sunlight, such as when
you are sunbathing, a massive amount of free iron is released in skin
cells.

"This free iron can act as catalysts for the generation of more harmful
free radicals that cause severe cell damage.

"Many forms of cancer are thought to be the result of reactions between
free radicals and DNA, causing mutations that can disrupt the cell
cycle and potentially lead to cancer.

When we are trying to protect ourselves from sunburn and skin cancer,
sunscreens should be used as a last line of defence

Dr Emma Knight of Cancer Research UK

"We wanted to find a way of mopping up sunlight-generated free iron
that produce harmful radicals during exposure to bright sunlight in
order to prevent the unwanted side reactions that can lead to skin
damage and ultimately cancer."

She said the best way to do this was to use chelators - drugs that bind
and export iron from the body.

"However, long term use of chelators can be toxic for cells as it
starves them of the iron necessary for normal biological processes, for
example the red blood cells that transport oxygen around the body need
iron to work," he said.

The researchers hope that new sunscreens containing these components
will also last longer than conventional sunscreen lotions.

Dr Emma Knight of Cancer Research UK said: "This is an interesting
study but the research is still at a very early stage.

"Much more work is crucial before we will know whether this approach
has potential for preventing skin cancer.

"When we are trying to protect ourselves from sunburn and skin cancer,
sunscreens should be used as a last line of defence.

"The most important thing is to avoid burning by spending time in the
shade between 11-3, and covering up with a T-shirt, hat and
sunglasses."

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

patti

2006-09-10, 4:27 pm

Im not going to get into a pissing match with you over your article.

it wouldnt pass any REAL scientific muster in a real research journal.

Im done

Patti

On 10 Sep 2006 08:39:51 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:

>
>Ok, I got just one question. Can someone tell me what all this means
>in layman's terms? <<
>
>
>Coming from a medical background <<
>
>
>And you will notice .. patti .. didn't answer the .. question .. ?
>
>Because .. ?
>Because .. ?
>
>She .. simply .. doesn't .. know .. or doesn't .. care ..
>
>One way or the other .. not .. much .. use .. on THIS .. 'particular'
>.. thread ..
>
>That would be .. 'evidence based' ..
>
>'They' are .. TARGETING the iron in the skin of those with autoimmune
>disease .. lupus .. and the other articles speak to the finding of iron
>in the skin reflecting the amount of iron IN the body
> .. and since the elevated levels of iron in the skin of lupus is ..
>KNOWN .. then one can dedeuce .. then .. the **body** levels of iron
>in those with lupus .. is .. ALSO .. elevated ..
>
>Pretty .. straight .. forward ..
>
>This story from .. yesterday .. explains it ..
>
>http://news.bbc.co.uk/2/hi/health/5326474.stm
>
>Suncream that can 'heal' sunburn
>
>The lotion is undergoing lab testing
>UK scientists say they have developed a sunscreen that will actively
>repair sunburnt skin and may even help prevent skin cancer.
>Like conventional suncreams, the lotion filters the sun's harmful rays.
>
>
>But an extra ingredient means it also helps mop up the free iron
>released when skin burns, the Bath university team found.
>
>This reduces inflammation, pain and prevents the build up of
>cancer-causing free radicals triggered by sunlight.
>
> Many forms of cancer are thought to be the result of reactions
>between free radicals and DNA
>
>Lead researcher Dr Charareh Pourzand
>
>The new ingredient - called a chelator - is light-responsive, meaning
>it only becomes active when it is exposed to UV radiation in sunlight.
>
>This should avoid any side effects that might result from long-term
>exposure to the active form of the drug, the authors told the Journal
>of Investigative Dermatology.
>
>Dr Charareh Pourzand, along with colleagues at Nottingham University,
>is currently testing prototypes of the ingredient in the laboratory,
>but expects to begin human trials in the next two to three years.
>
>Sun damage
>
>She said: "When skin is exposed to high doses of sunlight, such as when
>you are sunbathing, a massive amount of free iron is released in skin
>cells.
>
>"This free iron can act as catalysts for the generation of more harmful
>free radicals that cause severe cell damage.
>
>"Many forms of cancer are thought to be the result of reactions between
>free radicals and DNA, causing mutations that can disrupt the cell
>cycle and potentially lead to cancer.
>
> When we are trying to protect ourselves from sunburn and skin cancer,
>sunscreens should be used as a last line of defence
>
>Dr Emma Knight of Cancer Research UK
>
>"We wanted to find a way of mopping up sunlight-generated free iron
>that produce harmful radicals during exposure to bright sunlight in
>order to prevent the unwanted side reactions that can lead to skin
>damage and ultimately cancer."
>
>She said the best way to do this was to use chelators - drugs that bind
>and export iron from the body.
>
>"However, long term use of chelators can be toxic for cells as it
>starves them of the iron necessary for normal biological processes, for
>example the red blood cells that transport oxygen around the body need
>iron to work," he said.
>
>The researchers hope that new sunscreens containing these components
>will also last longer than conventional sunscreen lotions.
>
>Dr Emma Knight of Cancer Research UK said: "This is an interesting
>study but the research is still at a very early stage.
>
>"Much more work is crucial before we will know whether this approach
>has potential for preventing skin cancer.
>
>"When we are trying to protect ourselves from sunburn and skin cancer,
>sunscreens should be used as a last line of defence.
>
>"The most important thing is to avoid burning by spending time in the
>shade between 11-3, and covering up with a T-shirt, hat and
>sunglasses."
>
>Who loves ya.
>Tom
>
>
>Jesus Was A Vegetarian!
>http://jesuswasavegetarian.7h.com
>
>
>Man Is A Herbivore!
>http://tinyurl.com/a3cc3
>
>
>DEAD PEOPLE WALKING
>http://tinyurl.com/zk9fk
>

ironjustice@aol.com

2006-09-10, 4:27 pm

[vbcol=seagreen]
Im not going to get into a pissing match with you over your article.

it wouldnt pass any REAL scientific muster in a real research journal.

Im done

Patti<<

Actually if you look .. closely .. they are two .. DIFFERENT .. studies
...

Soooo .. means that more than 'just' .. me .. are 'interested' .. IN ..
iron ..

AND it also means .. MORE .. than your 'real' research journal .. are
... involved ..

Some pretty .. well educated .. well informed .. medical researchers ..
but I suppose we might listen to a .. former .. medical professional
who has now been shown to be .. or at least .. thank heavens .. former
... KILLING .. kids with your .. 'iron deficiency' .. diagnoses ..

Eh ..

How many pregnant mothers did YOU .. forcefeed .. iron .. to ..

How many kids .. or prospective kids have you .. killed .. ?

A few .. ?

Many .. ?

I wonder what the incidence of premature birth is in .. lupus .. ?

I wonder what the rate of .. complications in pregnancy .. there .. is
... ?

Would / does / could it .. correlate .. closely WITH .. elevated iron
... JUST .. like .. supplementing .. HEALTHY PREGNANT WOMEN .. like you
and your .. former .. cohorts .. ignorant .. cohorts .. have done and
STILL .. continue .. to .. do .. ?

<<snip>>
lead to birth complications for infants such as premature birth
<<snip>>

Main Category: Pregnancy News
Article Date: 01 Jun 2006 - 2:00am (PDT)

A new study conducted by researchers at Children's Hospital Oakland
Research Institute (CHORI), in close collaboration with scientists at
the National Institute of Perinatology in Mexico, is the first to show
that the current iron supplement recommendation for pregnant women who
are not anemic is too high and could lead to birth complications for
infants such as premature birth and low birth weight. This new research

conflicts with recommendations from the World Health Organization (WHO)

and the Centers for Disease Control (CDC). It is hoped that the results

of this study will lead to new recommendations from both organizations.

The study, featured in the May issue of Archives of Medical Research,
suggests that pregnant women who are not anemic should take iron
supplements weekly rather than daily. Women who are anemic have low
levels of healthy red blood cells and need higher doses of iron
supplementation. The study shows that pregnant women who are not anemic

and follow the recommended daily dosage can suffer from iron overload
and are more likely to experience birth complications.

Iron deficiency is common among women of childbearing age.
Consequently, doctors have ordered daily supplements of 60 to 120 mg of

iron to prevent or correct anemia and iron deficiency during pregnancy.

"What happens is that excess iron in pregnancy can drive the hemoglobin

levels above desirable levels, so that by the end of the second
trimester of pregnancy, 27 percent of the non-anemic women in our study

had hemoglobin levels that were undesirably high," said Fernando
Viteri, MD, Scientist at Children's Hospital Oakland Research Institute

(CHORI). "In these women, the risk of delivering premature babies or
newborns with low birth weight quadrupled."

In contrast, only 7 percent of the women on weekly supplements
developed high hemoglobin levels. The reason for the weekly dose - and
in far smaller amounts - is biological and corresponds with the
turnover of the intestinal lining, which renews itself every five to
six days. The fresh cells are programmed to absorb iron according to
the person's iron reserves and needs. The cells absorb more if reserves

are depleted and less if they are adequate. Dr. Viteri's research
concludes that iron supplementation is still beneficial, but must be
regulated based on whether a woman is anemic.

About Children's Hospital & Research Center Oakland

Children's Hospital & Research Center Oakland is a designated Level I
pediatric trauma center and the largest pediatric critical care
facility in the region. The hospital has 181 licensed beds and 166
hospital-based physicians in 31 specialties, more than two thousand
five hundred employees, and an operating budget of $287 million. The
hospital's research institute has an annual budget of $41 million with
more than 300 basic and clinic investigators. Children's Hospital
Oakland Research Institute (CHORI) has made significant progress in
areas including pediatric obesity, cancers, sickle cell disease,
AIDS/HIV, hemophilia and cystic fibrosis.

Diana Yee
d...@mail.cho.org
Children's Hospital & Research Center at Oakland
http://www.childrenshospitaloakland.org

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

ironjustice@aol.com

2006-09-13, 8:25 am

ironjustice@aol.com wrote:
>
> Ok, I got just one question. Can someone tell me what all this means
> in layman's terms? <<
>
>
> Coming from a medical background <<
>
>
> And you will notice .. patti .. didn't answer the .. question .. ?
>
> Because .. ?
> Because .. ?
>
> She .. simply .. doesn't .. know .. or doesn't .. care ..
>
> One way or the other .. not .. much .. use .. on THIS .. 'particular'
> .. thread ..
>
> That would be .. 'evidence based' ..
>
> 'They' are .. TARGETING the iron in the skin of those with autoimmune
> disease .. lupus .. and the other articles speak to the finding of iron
> in the skin reflecting the amount of iron IN the body
> .. and since the elevated levels of iron in the skin of lupus is ..
> KNOWN .. then one can dedeuce .. then .. the **body** levels of iron
> in those with lupus .. is .. ALSO .. elevated ..
>
> Pretty .. straight .. forward ..
>
> This story from .. yesterday .. explains it ..
>
> http://news.bbc.co.uk/2/hi/health/5326474.stm
>
> Suncream that can 'heal' sunburn
>
> The lotion is undergoing lab testing
> UK scientists say they have developed a sunscreen that will actively
> repair sunburnt skin and may even help prevent skin cancer.
> Like conventional suncreams, the lotion filters the sun's harmful rays.
>
>
> But an extra ingredient means it also helps mop up the free iron
> released when skin burns, the Bath university team found.
>
> This reduces inflammation, pain and prevents the build up of
> cancer-causing free radicals triggered by sunlight.
>
> Many forms of cancer are thought to be the result of reactions
> between free radicals and DNA
>
> Lead researcher Dr Charareh Pourzand
>
> The new ingredient - called a chelator - is light-responsive, meaning
> it only becomes active when it is exposed to UV radiation in sunlight.
>
> This should avoid any side effects that might result from long-term
> exposure to the active form of the drug, the authors told the Journal
> of Investigative Dermatology.
>
> Dr Charareh Pourzand, along with colleagues at Nottingham University,
> is currently testing prototypes of the ingredient in the laboratory,
> but expects to begin human trials in the next two to three years.
>
> Sun damage
>
> She said: "When skin is exposed to high doses of sunlight, such as when
> you are sunbathing, a massive amount of free iron is released in skin
> cells.
>
> "This free iron can act as catalysts for the generation of more harmful
> free radicals that cause severe cell damage.
>
> "Many forms of cancer are thought to be the result of reactions between
> free radicals and DNA, causing mutations that can disrupt the cell
> cycle and potentially lead to cancer.
>
> When we are trying to protect ourselves from sunburn and skin cancer,
> sunscreens should be used as a last line of defence
>
> Dr Emma Knight of Cancer Research UK
>
> "We wanted to find a way of mopping up sunlight-generated free iron
> that produce harmful radicals during exposure to bright sunlight in
> order to prevent the unwanted side reactions that can lead to skin
> damage and ultimately cancer."
>
> She said the best way to do this was to use chelators - drugs that bind
> and export iron from the body.
>
> "However, long term use of chelators can be toxic for cells as it
> starves them of the iron necessary for normal biological processes, for
> example the red blood cells that transport oxygen around the body need
> iron to work," he said.
>
> The researchers hope that new sunscreens containing these components
> will also last longer than conventional sunscreen lotions.
>
> Dr Emma Knight of Cancer Research UK said: "This is an interesting
> study but the research is still at a very early stage.
>
> "Much more work is crucial before we will know whether this approach
> has potential for preventing skin cancer.
>
> "When we are trying to protect ourselves from sunburn and skin cancer,
> sunscreens should be used as a last line of defence.
>
> "The most important thing is to avoid burning by spending time in the
> shade between 11-3, and covering up with a T-shirt, hat and
> sunglasses."
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

Since the skin levels reflect body iron stores .. and since skin iron
is
being TARGETED in lupus .. then one might dedeuce .. iron levels in
lupus to
BE .. **elevated** ..

Nuclear Instruments and Methods in Physics Research Section B: Beam
Interactions with Materials and Atoms
Volume 249, Issues 1-2 , August 2006, Pages 697-701
Ion Beam Analysis - Proceedings of the Seventeenth International
Conference
on Ion Beam Analysis

doi:10.1016/j.nimb.2006.03.120
Copyright =A9 2006 Elsevier B.V. All rights reserved.
Using skin to assess iron accumulation in human metabolic disorders

I=2E Guinotea, R. Flemingb, R. Silvac, P. Filipec, J.N. Silvac, A.
Ver=EDssimoa,
P=2E Napole=E3oa, d, L.C. Alvesa, d and T. Pinheiroa, d, ,

aLaborat=F3rio de Feixes de I=F5es, Instituto Tecnol=F3gico e Nuclear,
E=2EN. 10,
2685-953 Sacav=E9m, Portugal
bImunohaemotherapy Department, Hospital de St. Maria, Lisboa, Portugal
cDermatology Department, Hospital de St. Maria, Lisboa, Portugal
dCentro de F=EDsica Nuclear, Universidade de Lisboa, Portugal

Available online 16 May 2006.
Abstract
The distribution of Fe in skin was assessed to monitor body Fe status
in
human hereditary hemochromatosis. The paper reports on data from nine
patients with hemochromatosis that were studied along the therapeutic
programme. Systemic evaluation of Fe metabolism was carried out by
measuring
with PIXE technique the Fe concentration in plasma and blood cells, and
by
determining with biochemical methods the indicators of Fe transport in
serum
(ferritin and transferrin). The Fe distribution and concentration in
skin
was assessed by nuclear microscopy and Fe deposits in liver estimated
through nuclear magnetic resonance. Elevated Fe concentrations in skin
were
related to increased plasma Fe (p < 0.004), serum ferritin content (p <

0=2E01) and Fe deposits in liver (p < 0.004). The relationship of Fe
deposits
in organs and metabolism markers may help to better understand Fe pools

mobilisation and to establish the quality of skin as a marker for the
disease progression and therapy efficacy.

Keywords: Nuclear microprobe; Skin; Blood; Iron; Hemochromatosis

PACS classification codes: 07.77.Ka; 87.57.−s; 87.64.−t;
87.59.Jq; 82.80.−d; 87.19.Xx

Corresponding author. Address: Laborat=F3rio de Feixes de I=F5es,
Instituto
Tecnol=F3gico e Nuclear, E.N. 10, 2685-953 Sacav=E9m, Portugal. Tel.:
+351 21
994 6250; fax: +351 21 994 1525.

Nuclear Instruments and Methods in Physics Research Section B: Beam
Interactions with Materials and Atoms
Volume 249, Issues 1-2 , August 2006, Pages 697-701
Ion Beam Analysis - Proceedings of the Seventeenth International
Conference
on Ion Beam Analysis

---------------------------------------------------------------------------=
=AD-----

http://www.napa.ufl.edu/2002news/cheladerm.htm

<<snip>>
The trials initially will focus on individuals with the autoimmune
disease lupus, who are extremely sensitive to the sun.
<<snip>>

GAINESVILLE, Fla. --- The university of Florida and Procter & Gamble
today
announced they have joined forces to advance research on
Photoprotective Iron
Chelator Technology, which was developed by P&G and shows promise for
preventing or reducing the harmful effects of the sun, particularly
skin
cancer.

------

Phys Med Biol 2000 May;45(5):1387-96

The use of skin Fe levels as a surrogate marker for organ Fe levels, to

monitor
treatment in cases of iron overload.

Farquharson MJ, Bagshaw AP, Porter JB, Abeysinghe RD

Department of Radiography, City University, London, UK.

[Medline record in process]

A system based on the detection of K-shell x-ray fluorescence (XRF)
has been used to investigate whether a correlation exists between
the
concentration of iron in the skin and the concentration of iron in
the
liver, as the degree of iron loading increases. The motivation
behind
this work is to develop a non-invasive method of determining the
extent of the body's iron stores via measurements on the skin, in
order to monitor the efficacy of chelation therapy administered to
patients with beta-thalassaemia. Sprague-Dawley rats were iron
loaded
via injections of iron dextran and subsequently treated with the
iron
chelator CP94. The non-haem iron concentrations of the liver, heart
and spleen were determined using bathophenanthroline sulphonate as
the
chromogen reagent. Samples of abdominal skin were taken and the iron
concentrations determined using XRF. A strong correlation between
the
skin iron concentration and the liver iron concentration has been
demonstrated (R2 =3D 0.86). Similar correlations exist for the heart
and
the spleen. These results show that this method holds great
potential
as a tool in the diagnosis and treatment of hereditary
haemochromatosis and beta-thalassaemia.

PMID: 10843111, UI: 20300097
_________________________________________________________________

http://tinyurl.com/zgwfm

<<snip>>
One of the more unusual presentations described how lecithin applied
topically to the skin decreased blood cholesterol in people with normal

and high blood cholesterol levels.
<<snip>>

http://tinyurl.com/f8cs8

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk