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Home > Archive > Lupus Support > August 2006 > Iron overload leads to pathological viscosity
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Iron overload leads to pathological viscosity
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| ironjustice@aol.com 2006-08-11, 8:25 am |
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Hemorheological status and redox homeostasis of phlebotomised porphyria
cutanea tarda patients with diabetes mellitus and in moderate alcohol
consumer.
Sz=E9kely E, Bor M, Tasn=E1di G, V=E1rnai K, Alm=E1si A, Bl=E1zovics A
Clin Hemorheol Microcirc. 2006; 35(3): 387-96
Increase in porphyrin concentration is caused by the decreased activity
of uroporphyrinogen decarboxylase in porphyria cutanea tarda (PCT).
Iron overload, alcohol consumption and diabetes mellitus play role in
the development of PCT. We investigated the hemorheological and
redox-parameters from the blood of 34 male PCT patients and 10 male
volunteers. The disfunctions were investigated by pathological amounts
of iron and lipid metabolism. Routine laboratory and hemorheological
parameters, plasma free SH-group concentration, H-donating ability and
reducing power were measured by spectrophotometry. Free radical
activity was determined by chemiluminometry method. The hemorheological
parameters were significantly increased in all three groups of PCT
patients compared to the controls. Negative correlations were observed
between blood viscosity and antioxidant defence of PCT patients and in
PCT patients with alcohol consumption. Plasma and erythrocyte
chemiluminescent intensity was higher in PCT patients than in controls,
which indicated the decrease of antioxidant defence. Hemorheological
parameters were highest in patients with diabetes and in alcohol
consumers. Iron overload increased free radical reactions in PCT
patients, leading to pathological viscosity. Increased free radical
reactions and high blood viscosity increase the risk of cardiovascular
diseases.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20
http://tinyurl.com/zk9fk
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ironjustice@aol.com wrote:
> Hemorheological status and redox homeostasis of phlebotomised porphyria
> cutanea tarda patients with diabetes mellitus and in moderate alcohol
> consumer.
> Sz=E9kely E, Bor M, Tasn=E1di G, V=E1rnai K, Alm=E1si A, Bl=E1zovics A
> Clin Hemorheol Microcirc. 2006; 35(3): 387-96
>
> Increase in porphyrin concentration is caused by the decreased activity
> of uroporphyrinogen decarboxylase in porphyria cutanea tarda (PCT).
> Iron overload, alcohol consumption and diabetes mellitus play role in
> the development of PCT. We investigated the hemorheological and
> redox-parameters from the blood of 34 male PCT patients and 10 male
> volunteers. The disfunctions were investigated by pathological amounts
> of iron and lipid metabolism. Routine laboratory and hemorheological
> parameters, plasma free SH-group concentration, H-donating ability and
> reducing power were measured by spectrophotometry. Free radical
> activity was determined by chemiluminometry method. The hemorheological
> parameters were significantly increased in all three groups of PCT
> patients compared to the controls. Negative correlations were observed
> between blood viscosity and antioxidant defence of PCT patients and in
> PCT patients with alcohol consumption. Plasma and erythrocyte
> chemiluminescent intensity was higher in PCT patients than in controls,
> which indicated the decrease of antioxidant defence. Hemorheological
> parameters were highest in patients with diabetes and in alcohol
> consumers. Iron overload increased free radical reactions in PCT
> patients, leading to pathological viscosity. Increased free radical
> reactions and high blood viscosity increase the risk of cardiovascular
> diseases.
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
Did you cut and paste that or do you really know what all that means :o
Chris
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