| ironjustice@aol.com 2006-08-09, 8:25 am |
| <<snip>>
CONCLUSION: RA and SLE patients have HIGH levels of prooxidants (MDA
and NO) whereas their antioxidant enzymes (SOD and GPO) activity was
LOW.
<<snip>>
[Pro- and antioxidant blood system in patients with rheumatoid
arthritis and systemic lupus erythematosus]
Ter Arkh. 2006; 78(6): 10-4
AIM: To estimate the levels of prooxidants (malonic dialdehyde-MDA and
nitric oxide-NO), Zn, activity of antioxidant enzymes (superoxide
dismutase--SOD and glutathione peroxidase--GPO) in the blood of
patients with rheumatoid arthritis (RA) and systemic lupus
erythematosus (SLE). MATERIAL AND METHODS: Pro- and antioxidant system
was assessed in 45 RA patients and 32 SLE patients by content of MDA
estimated by reaction with thiobarbituric acid, NO (Boehringer Manheim
kits, Germany), Zn (Unicam SP 190/191, Great Britain), activity of SOD
and GPO (kits Ransod, Ransel; Randox, Great Britain). RA activity was
evaluated by DAS index, SLE--by SLEDAI. RESULTS: MDA and NO
concentrations were found elevated while SOD and GPO activity low in RA
and SLE. The level of Zn was subnormal in RA. The activity of RA and
SLE did not influence the above indices significantly. CONCLUSION: RA
and SLE patients have high levels of prooxidants (MDA and NO) whereas
their antioxidant enzymes (SOD and GPO) activity was low. This may
promote oxidant stress.
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