| ironjustice@aol.com 2006-08-05, 2:27 am |
| Impact of oral vitamin E supplementation on oxidative stress & lipid
peroxidation in patients with polymorphous light eruption.
Ahmed RS, Suke SG, Seth V, Jain A, Bhattacharya SN, Banerjee BD
Indian J Med Res. 2006 Jun ; 123(6): 781-7
BACKGROUND & OBJECTIVES: Polymorphous light eruption (PMLE) is a
photo-induced disease which clinically manifests in the form of
pruritic eruptions on sun/light exposed parts. Little is known about
lipid peroxidation and free radical scavengers in patients during PMLE.
The present study was therefore undertaken to evaluate oxidative stress
and levels of antioxidant enzymes in patients of PMLE. METHODS: The
PMLE was diagnosed clinically by a consultant dermatologist and
validated independently by another and through histopathologic
findings. Blood samples were collected on day 1 and patients were given
oral vitamin E supplementation (400 mg OD) along with topical sunscreen
and advice for photo-protection. Samples were collected again after one
week. The blood samples were evaluated for lipid peroxidation, oxygen
free radical (OFR) scavenging enzymes, glutathione (GSH) and related
enzymes such as glutathione reductase (GR), glutathione peroxidase
(GPx), gamma glutamyl transpeptidase (GGT) and glutathione-
S-transferase (GST) in erythrocytes and compared with healthy controls.
RESULTS: The serum malondialdehyde (MDA) level was higher and GSH level
was lower in PMLE cases as compared to controls. There was a
significant decrease in superoxide dismutase (SOD) activity while
activities of catalase (CAT) and glutathione related enzymes were
increased in PMLE cases. Administration of oral vitamin E for one week,
along with photoprotection resulted in a significant decrease in MDA
levels and activities of all others enzymes except SOD. The GSH was
replenished and returned to normal. INTERPRETATION & CONCLUSION:
Oxidative stress and differential modulation of antioxidant enzymes in
PMLE might play a pathogenic role in humans, which supports the
incorporation of antioxidant drugs in the treatment protocol of the
disease.
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