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The Journal of Nutritional Biochemistry
Volume 17, Issue 3 , March 2006, Pages 183-189
doi:10.1016/j.jnutbio.2005.07.001
Copyright =A9 2006 Elsevier Inc. All rights reserved.
Research article
Mediterranean vegetable soup consumption increases plasma vitamin C and
decreases F2-isoprostanes, prostaglandin E2 and monocyte chemotactic
protein-1 in healthy humans
Concepci=F3n S=E1nchez-Morenoa, b, , , M. Pilar Canob, Bego=F1a de Ancosb,
Luc=EDa Plazab, Bego=F1a Olmedillac, Fernando Granadoc and Antonio
Mart=EDna
aNutrition and Neurocognition Laboratory, Jean Mayer USDA-Human
Nutrition Research Center on Aging at Tufts University, Boston, MA
02111, USA
bDepartment of Plant Foods Science and Technology, Instituto del
Fr=EDo-CSIC, E-28040 Marid, Spain
cUnit of Vitamins, Section of Nutrition, Cl=EDnica Puerta de Hierro,
28035 Madrid, Spain
Available online 15 August 2005.
Abstract
Consumption of fruits and vegetables is associated with a reduced risk
of death from all causes including heart disease and stroke. In this
work, the bioavailability of vitamin C from a Mediterranean vegetable
soup (gazpacho) constituted mainly of tomato, pepper and cucumber, and
its influence on plasma vitamin C, 8-epi-prostaglandin F2a
(8-epi-PGF2a), prostaglandin E2 (PGE2), monocyte chemotactic protein-1
(MCP-1), and the cytokines/tumor necrosis factor-a (TNF-a),
interleukin-1=DF (IL-1=DF), and IL-6 concentrations in a healthy human
population were assessed. Six men and six women consumed 500 ml of
commercial gazpacho per day for 14 days, corresponding to an intake of
78 mg of ascorbic acid per day. There were no differences (P=3D.22) in
baseline plasma vitamin C concentrations between the men and women. The
maximum increase (P<.05) in plasma vitamin C occurred 4 h postdose in
both men and women. Vitamin C concentrations were significantly higher
(P<.03) on Days 7 and 14 of the intervention. Baseline concentrations
of uric acid and 8-epi-PGF2a were significantly higher (P=3D.032) in men
than in women. Baseline concentrations of 8-epi-PGF2a decreased
significantly (P=3D.05) by Day 14 of the intervention. A significant
inverse correlation was observed between vitamin C and 8-epi-PGF2a
(r=3D-.415, P=3D.049). Baseline concentrations of PGF2 and MCP-1 were
significantly higher (P=3D.025) in men than in women but decreased
significantly (P=3D.05) by Day 14 of the intervention. No effect on
TNF-a, IL-1=DF and IL-6 was observed at Day 14 of the intervention.
Drinking gazpacho (500 ml/day) significantly increases plasma
concentrations of vitamin C and significantly decreases 8-epi-PGF2a,
PGE2 and MCP-1 concentrations in healthy humans.
Keywords: Vegetable soup; Vitamin C; Bioavailability; F2-Isoprostanes;
Uric acid; Cytokines; Inflammatory markers
Supported in part by the Coordinated Grant CAM 07G/0040/2000-CAM
07G/0041/2000 (Comunidad Aut=F3noma de Madrid), the Grant
AGL2002-04059-C02-02 (Ministry of Science and Technology, Madrid,
Spain) (MPC); a Fulbright/Ministry of Education, Culture and Sports
Award for Postdoctoral Research in the United States of America,
Visiting Scholar Program, Commission for Cultural, Educational and
Scientific Exchange between the United States of America and Spain, and
a Ram=F3n y Cajal Research Contract (Ministry of Science and Technology,
Madrid, Spain) (CS-M). An earlier version of this article was presented
at Experimental Biology 2004, Washington DC, USA, April 2004.
Corresponding author. Department of Plant Foods Science and Technology,
Instituto del Fr=EDo, Consejo Superior de Investigaciones Cient=EDficas
(CSIC), C/Jos=E9 Antonio Novais 10, Ciudad Universitaria, E-28040
Madrid, Spain. Tel.: +34 91 549 23 00, +34 91 544 56 07; fax: +34 91
549 36 27.
The Journal of Nutritional Biochemistry
Volume 17, Issue 3 , March 2006, Pages 183-189
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