Lupus Support - Uric acid / gout / IRON

Author

Uric acid / gout / IRON

ironjustice@aol.com

2005-03-29, 7:24 pm

Free Radic Res. 2005 Mar;39(3):337-42. Related Articles, Links

The association between serum ferritin and uric acid in humans.

Ghio AJ, Ford ES, Kennedy TP, Hoidal JR.

National Health and Environmental Effects Research Laboratory Office of
Research and Development, Environmental Protection Agency Research
Triangle Park, NC 27711 USA.

Objective: Urate forms a coordination complex with Fe(3+) which does
not support electron transport. The only enzymatic source of urate is
xanthine oxidoreductase. If a major purpose of xanthine oxidoreductase
is the production of urate to function as an iron chelator and
antioxidant, a system for coupling the activity of this enzyme to the
availability of catalytically-active metal would be required. We tested
the hypothesis that there is an association between iron availability
and urate production in healthy humans by correlating serum
concentrations of ferritin with uric acid levels. Materials and
methods: The study population included 4932 females and 4794 males in
the National Health and Nutrition Examination Survey III. They were 20
years of age or older and in good health. Results: Serum concentrations
of ferritin correlated positively with uric acid levels in healthy
individuals. This association was independent of an effect of gender,
age, race/ethnic group, body mass, and alcohol consumption.
Conclusions: The relationship between serum ferritin and uric acid
predicts hyperuricemia and gout in groups with iron accumulation. This
elevation in the production of uric acid with increased concentrations
of iron could possibly reflect a response of the host to diminish the
oxidative stress presented by available metal as the uric acid assumes
the empty or loosely bound coordination sites of the iron to diminish
electron transport and subsequent oxidant generation.

PMID: 15788238 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://herbivore.7h.com

spodosaurus

2005-03-29, 7:24 pm

ironjustice@aol.com wrote:
<stuff Tom doesn't understand snipped>

Tom, that article only applies to people with haemocromatosis, not to
the general population. Once again, you've shown you're unable to read
and comprehend (or more probably either of those things in isolation,
the combined activity being far beyond your means) what you're copy and
pasting. Here's an idea: go to school, get a degree, and run an experiment!

Wait...

No....

You're an imbecile, that'll never happen...

Oh well, time for you to go back to your compulsive masturbating again.

All the best!

--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

ironjustice@aol.com

2005-03-29, 7:24 pm

WHERE does it say .. hemochromatosis .. ?

It doesn't .. say .. hemochromatosis ..

<<snip>>Results: Serum concentrations of ferritin correlated positively
with uric acid levels in HEALTHY INDIVIDUALS
<<snip>>

YOU .. think .. it SAYS ... hemochromatosis .. ?

That means you are .. stupid ..

Doesn't .. it ..

But that is evidence .. based ..

Eh ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://herbivore.7h.com

firechief

2005-03-29, 7:24 pm

> Tom, that article only applies to people with haemocromatosis,...
> Here's an idea: go to school, get a degree, and run an experiment!

He has to earn his dipolma from kindergarten, then junior high
school, the senior high school before he can get a degree.

.... Tom thought the town hooker was into needlecraft.

spodosaurus

2005-03-29, 7:24 pm

ironjustice@aol.com wrote:
> WHERE does it say .. hemochromatosis .. ?
>
> It doesn't .. say .. hemochromatosis ..
>
> <<snip>>Results: Serum concentrations of ferritin correlated positively
> with uric acid levels in HEALTHY INDIVIDUALS
> <<snip>>
>
> YOU .. think .. it SAYS ... hemochromatosis .. ?
>
> That means you are .. stupid ..

No, it means you're retarded:

"Conclusions: The relationship between serum ferritin and uric acid
predicts hyperuricemia and gout in groups with iron accumulation."

You don't even understand two words put together: iron accumulation.

Lol

idiot

--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

ironjustice@aol.com

2005-03-29, 7:24 pm

>>
"Conclusions: The relationship between serum ferritin and uric acid
predicts hyperuricemia and gout with iron accumulation"

You don't even understand two words put together . iron accumulation.<<

The uric acid rises AS the iron rises ..

That would mean .. yes .. iron accumulation IS .. involved .. simply
BECAUSE .. iron was the mineral they were watching ..

Now since the individuals ARE .. healthy .. therefore .. NO ..
*genetic* .. iron overload / iron accumulation .. then the rise in uric
acid which rises AS .. the .. IRON .. rises .. is .. RISING .. because
... the IRON .. is rising .. DUE TO .. environmental causes .. which
would INCLUDE .. ingestion .. eating .. OF .. iron ..

I suppose THAT would explain why bloodletting is shown to be EFFECTIVE
... in .. gout ..

Eh ..

But THAT would be too hard for YOU to understand ..

Since you ARE .. stupid ..

Heh .. heh ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://herbivore.7h.com

spodosaurus

2005-03-29, 7:24 pm

ironjustice@aol.com wrote:
> "Conclusions: The relationship between serum ferritin and uric acid
> predicts hyperuricemia and gout with iron accumulation"
>
> You don't even understand two words put together . iron accumulation.<<
>
> The uric acid rises AS the iron rises ..

In healthy people, yes. But healthy people don't have iron accumulation,
genius. The only gout->iron link is in people with iron accumulation who
MAY according to that study develop high uric acid levels. Like I said,
if you had the intellectual means, you'd actually get an education and
conduct these experiements rather than just copy and pasting things
you've misunderstood.

cheers!

--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

ironjustice@aol.com

2005-03-29, 7:24 pm

>>rather than just copy and pasting things you've musunderstood<<

The iron in healthy humans rises parallel TO the uric acid .. the iron
in people with iron accumulation parallels the uric acid levels ..

So .. unless .. you are VERY stupid .. one can ..understand .. that is
... U-N-D-E-R-S-T-A-N-D .. the iron levels parallel the uric acid levels
...

Do you know what parallel .. means .. or are you ALSO too stupid to use
a dictionary ..

It means .. 'goes along hand in hand' .. so .. as I said before .. the
iron rises as the uric acid rises or the uric acid rises as the iron
rises ..

Too easy for ya .. ?

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://herbivore.7h.com

spodosaurus

2005-03-29, 7:24 pm

ironjustice@aol.com wrote:
>
>
> The iron in healthy humans rises parallel TO the uric acid ..

Wrong. The uric acid MAY rise with ferritin, an indirect measure of iron
content that is also a liver inflamatory protein.

> the iron
> in people with iron accumulation parallels the uric acid levels ..

No, it doesn't. My uric acid levels are low. I have massive iron stores
and extremely high ferritin. You're still not understanding, but then
again, you never do.

And no, you cannot send me any more photographs. That was some sick
stuff. You need help.

--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/