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Home > Archive > Lupus Support > March 2005 > Hormone replacement and Lupus
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Hormone replacement and Lupus
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| Here's what I've gathered. Read them each - I'm only copying some of the
text
There seems to be a SELENA study (no idea if it's ongoing, finished) about
hormone replacement.
There's phone number here for questions.
http://tarc.med.unc.edu/resselena.php
Other links (some disagree with each other) on HRT - several have warnings
about existing liver problems - maybe others - you have to read and list
the warnings.
http://www.lupusuk.com/factsheets/l...dmedication.pdf (adobe acrobat
file)
http://www.bupa.co.uk/health_inform...ne/hormone.html
<http://www.ncbi.nlm.nih.gov/entrez/...7&dopt=Abstract>
2001;
<http://www.ncbi.nlm.nih.gov/entrez/...9&dopt=Abstract>
1998
http://www.lupusmn.org/Education/Ar...nesandLupus.htm
http://imaginis.com/breasthealth/hrt.asp (general, only valuely mentions
Lupus)
http://www.clinicaltrials.gov/ct/show/NCT00005108 Clinical Trial -
Completed
Effects of Hormone Replacement Therapy on Inflammation and Stiffening of
Artery Walls
http://www.cmaj.ca/cgi/content/full/168/8/1001 April 15, 2003;
Risks and benefits of hormone replacement therapy: The evidence speaks
Observational evidence on the effect of HRT on certain systemic diseases
is controversial. HRT has been shown to be beneficial in some diseases,
such as type 2 diabetes mellitus,88 osteoarthritis89 and rheumatoid
arthritis,90 but not in others, including systemic lupus erythematosus,91
antiphospholipid antibody syndrome92 and asthma.93,94 Again, RCT data are
lacking, although studies are under way to assess these issues further.92
<read the rest>
Conclusion
Use of HRT should be individualized, the risks and benefits of HRT for
each woman being taken into consideration.
http://www.niams.nih.gov/hi/topics/...sguide/chp2.htm
Improve Reproductive Health in Women With Lupus
Because of recent improvements in diagnostic tools for lupus and a better
understanding of the disease, doctors can now predict the likelihood of a
lupus-related miscarriage and identify women at risk for giving birth to
babies with neonatal lupus. Doctors and lupus patients can now take
measures to prevent miscarriages, and doctors can prepare to treat those
babies born with neonatal heart block, the most serious complication of
neonatal lupus.
Progress is also being made in another important area of reproductive
health. In the past, women with lupus have not been able to use oral
contraceptives or take advantage of hormone replacement therapy because of
concerns that estrogens exacerbate lupus. However, recent data suggest
these drugs may be safe for some women with lupus, and a current study
funded by NIAMS, the NIH Office of Research on Women?s Health, and the NIH
Office of Research on Minority Health is focusing on the safety and
effectiveness of oral contraceptives and hormone replacement therapy in
women with lupus. This clinical trial is called the Safety of Estrogen in
Lupus Erythematosus National Assessment (SELENA). Researchers hope this
study will yield options for safe, effective methods of contraception for
young women with lupus as well as options for estrogen replacement therapy
for postmenopausal women with lupus.
I think this is Andy's website http://www.infotech.demon.co.uk/HRT.htm
The decision to use HRT in women with lupus is a difficult one. There have
been a few isolated reports of a severe reaction to postmenopausal
oestrogen, even though the doses are much lower than used in the pill. A
proper trial of HRT in lupus has not been carried out to assess accurately
the risks and benefits. However, two studies have looked back at the
experiences of women with lupus who took HRT, compared to controls, and
found encouraging results. The HRT group had no more adverse reactions and
generally felt better. Lupus patients are particularly at risk of
osteoporosis, often because of steroid use over a long period, and the
disease itself may also thin the bone to a small extent.
It is difficult to give clear guidelines on the use of HRT in lupus. Women
soon after menopause, who have taken steroids for many years and whose
disease is relatively stable should be considered, particularly if they
have had an early menopause (before 45), removal of the ovaries, or
hysterectomy. One way of assessing the risk is to perform a bone density
scan. A new hormone "Evista" is now available and may be useful for lupus
patients who are worried about the breast side effects of HRT, although
data is limited.
In summary, HRT can be useful to some women with lupus, although in a few
there is a risk of making the disease worse. the decision whether or not
to use hormones should be taken after careful discussion and assessment of
the individual case with a rheumatologist and the patient should be
monitored closely when hormones are prescribed. <end quote>
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| In article <4224B358.2ACC3B6@execulink.com>, jay <fce@anon.invalid>
wrote
[]
>I think this is Andy's website http://www.infotech.demon.co.uk/HRT.htm
Not guilty. If it is what I recall, it is indeed a UK site, though. The
diseases/conditions and the treatment/medicine will be the same as in
any other country, but the names of drugs and the basis of the
medic-patient interaction can be confusingly different.
--
Andy Taylor [Chair, N E Lupus Group]
See http://www.northeastlupus.org.uk for more!
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| Andy wrote:
> In article <4224B358.2ACC3B6@execulink.com>, jay <fce@anon.invalid>
> wrote
> []
>
> Not guilty. If it is what I recall, it is indeed a UK site, though. The
> diseases/conditions and the treatment/medicine will be the same as in
> any other country, but the names of drugs and the basis of the
> medic-patient interaction can be confusingly different.
Sorry for my error
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