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Home > Archive > Lupus Support > March 2005 > LDN
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| Diane Fblooms 2005-03-19, 6:19 pm |
| Has this drug been talked about here at all? I joined an on-line group
for LDN and am just learning about it. Thought I'd mention it incase
others wanted to look into it too. I'm interested because of it's low
side effects since I can't take other medications for Lupus. It is
being used for many illnesses not just Lupus, MS is one thing it is also
being used for.
I'm going to bring info to my doctor to see if maybe I can try it for my
Lupus. It isn't FDA approved yet but trials are taking place for it's
use for immune problems. Some are getting a script from there doctors
and having a compounding pharmacy making up their prescription.
Diane
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| Diane Fblooms wrote:
> Has this drug been talked about here at all? I joined an on-line group
> for LDN and am just learning about it. Thought I'd mention it incase
> others wanted to look into it too. I'm interested because of it's low
> side effects since I can't take other medications for Lupus. It is
> being used for many illnesses not just Lupus, MS is one thing it is also
> being used for.
>
> I'm going to bring info to my doctor to see if maybe I can try it for my
> Lupus. It isn't FDA approved yet but trials are taking place for it's
> use for immune problems. Some are getting a script from there doctors
> and having a compounding pharmacy making up their prescription.
If it's called Naltrexone, doesn't sound like a good idea to me for Lupus,
because it boosts the immune system.
If you want to know the latest for Lupus, watch for Janers or other regulars
here to tell you about them.
No sign of naltrexone for US clinical trials.
http://www.nationalmssociety.org/Clinup-Naltrexone.asp
Naltrexone is an opioid antagonist that has been approved by the U.S. Food
and Drug Administration (FDA) since the early 1990s for the treatment of
addictions to opioids and alcohol. At significantly lower doses, it has been
marketed on the Internet as a treatment for a variety of diseases, including
various types of cancers, HIV/AIDS, Parkinson's disease, Alzheimer's
disease, amyotrophic lateral sclerosis (ALS), emphysema, as well as MS and
other autoimmune diseases. There are, however, no published reports of
placebo-controlled clinical trials demonstrating the safety and efficacy of
naltrexone in any of these diseases. The marketing efforts rely entirely on
anecdotal reports.
Naltrexone is said to work in MS and other diseases by adjusting the level
of endorphins in the body to enhance immune function. Enhancement of the
immune system, however, is not recommended for anyone with MS. Because MS is
thought to be an autoimmune disease, in which the immune system mistakenly
attacks the myelin in the central nervous system, the goal of currently
approved treatments is to inhibit the overactive immune response rather
than boost it.
(this is a website "selling the idea") not one I would look to for good
information.
http://www.lowdosenaltrexone.org/ldn_trials.htm
Clinical Trials for LDN
Although, as of December 2004, there are yet no published medical reports of
a definitive clinical trial for low dose naltrexone, there are three current
clinical trials in various stages of progress—for Crohn's disease, irritable
bowel syndrome, and, in Germany, a small trial for MS.
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| Diane Fblooms 2005-03-19, 6:19 pm |
| Thanks Jay, I know so little about all this.
I don't really understand what's meant by an overactive immune system,
does it works too poorly or too well?
I don't just have the Lupus, I also have serious allergy problems so I
sure have a serious overactive thing going on.
Diane
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| jay wrote:
> If it's called Naltrexone, doesn't sound like a good idea to me for Lupus,
> because it boosts the immune system.
> If you want to know the latest for Lupus, watch for Janers or other regulars
> here to tell you about them.
> No sign of naltrexone for US clinical trials.
>
> http://www.nationalmssociety.org/Clinup-Naltrexone.asp
> Naltrexone is an opioid antagonist that has been approved by the U.S. Food
> and Drug Administration (FDA) since the early 1990s for the treatment of
> addictions to opioids and alcohol. At significantly lower doses, it has been
> marketed on the Internet as a treatment for a variety of diseases, including
> various types of cancers, HIV/AIDS, Parkinson's disease, Alzheimer's
> disease, amyotrophic lateral sclerosis (ALS), emphysema, as well as MS and
> other autoimmune diseases. There are, however, no published reports of
> placebo-controlled clinical trials demonstrating the safety and efficacy of
> naltrexone in any of these diseases. The marketing efforts rely entirely on
> anecdotal reports.
>
> Naltrexone is said to work in MS and other diseases by adjusting the level
> of endorphins in the body to enhance immune function. Enhancement of the
> immune system, however, is not recommended for anyone with MS. Because MS is
> thought to be an autoimmune disease, in which the immune system mistakenly
> attacks the myelin in the central nervous system, the goal of currently
> approved treatments is to inhibit the overactive immune response rather
> than boost it.
http://www.mssociety.org.uk/researc...lained/ldn.html
The logic of using LDN in multiple sclerosis – that it boosts immune function –
goes against the conventional view that the immune system is inappropriately
active and needs to be suppressed.
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