| ironjustice@aol.com 2005-01-31, 11:53 am |
| <<snip>>
Our findings suggest that oxidative stress is implicated in the
pathogenesis of SLE
<<snip>>
Clin Invest Med. 2004 Dec;27(6):306-11. Related Articles, Links
8-Isoprostaglandin F2 alpha: a potential index of lipid peroxidation in
systemic lupus erythematosus.
Abou-Raya A, el-Hallous D, Fayed H.
Rheumatology Unit, Internal Medicine Department, Faculty of Medicine,
University of Alexandria, Alexandria, Egypt. aaraya@internetalex.com
BACKGROUND: Lipid peroxidation is a central feature of oxidant injury
that leads to the vascular disease associated with systemic lupus
erythematosus (SLE). In the past, lipid peroxidation has been difficult
to measure. Because isoprostanes are thought to have particular
relevance in vascular disease, we set out to measure, in vivo, serum
concentrations of 8-isoprostaglandin F2 alpha (8-iso-PGF2alpha) as a
marker of oxidative stress to evaluate the occurrence and ascertain the
significance of lipid peroxidation in SLE. METHODS: Sixty patients with
SLE and 20 age- and sex-matched controls were recruited. Patients were
assessed according to a standard protocol, including demographic,
clinical, laboratory and treatment variables. We measured the serum
concentrations of 8-iso-PGF2alpha using the enzyme-linked
immunoabsorbent assay. Fasting lipid profiles and serum lipid peroxide
concentrations were also assessed in both SLE patients and controls.
RESULTS: In SLE patients, with a mean age of 22.4 (standard deviation
[SD] 2.7) years and a disease duration of 20.9 (SD 4.9) months, the
serum concentrations of 8-iso-PGF2alpha were higher than in the age-
and sex-matched controls (p < 0.001). The mean level of 8-iso-PGF2alpha
in SLE patients was 466 (SD 296.8) pg/mL compared with a mean of 90.9
(SD 26.6) pg/mL in the control group (p < 0.001). Our findings revealed
a dose-response relationship between 8-iso-PGF2alpha concentrations and
the dosage of prednisone. The level of serum lipid peroxide in SLE
patients was increased compared with levels measured in the control
group. CONCLUSIONS: Our findings suggest that oxidative stress is
implicated in the pathogenesis of SLE and that 8-iso-PGF2alpha can be
used as a sensitive, noninvasive, reliable marker of oxidative stress
in vivo. Furthermore, it should be possible to target therapies more
effectively so that the detrimental actions of vascular oxygen free
radicals can be reduced.
PMID: 15675110 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
|