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| J Nutr. 2004 Nov;134(11):3021-5. Related Articles, Links
Consumption of high-pressurized vegetable soup increases plasma vitamin C and
decreases oxidative stress and inflammatory biomarkers in healthy humans.
Sanchez-Moreno C, Cano MP, de Ancos B, Plaza L, Olmedilla B, Granado F, Martin
A.
Nutrition and Neurocognition Laboratory, Jean Mayer U.S. Department of
Agriculture-Human Nutrition Research Center on Aging at Tufts University,
Boston, MA;
Current evidence supports a significant association between fruit and vegetable
intake and health. In this study, we assessed the effect of consuming a
vegetable-soup "gazpacho" on vitamin C and biomarkers of oxidative stress and
inflammation in a healthy human population. We also examined the association
between vitamin C and F(2)-isoprostanes (8-epiPGF(2alpha)), uric acid (UA),
prostaglandin E(2) (PGE(2)), monocyte chemotactic protein-1 (MCP-1), and the
cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta
(IL-1beta), and IL-6. Gazpacho is a Mediterranean dish defined as a
ready-to-use vegetable soup, containing approximately 80% crude vegetables rich
in vitamin C. Subjects (6 men, 6 women) enrolled in this study consumed 500
mL/d of gazpacho corresponding to an intake of 72 mg of vitamin C. On d 1,
subjects consumed the gazpacho in one dose; from d 2 until the end of the
study, d 14, 250 mL was consumed in the morning and 250 mL in the afternoon.
Blood was collected before drinking the soup (baseline) and on d 7 and 14.
Baseline plasma vitamin C concentrations did not differ between men and women
(P = 0.060). Compared with baseline, the vitamin C concentration was
significantly higher on d 7 and 14 of the intervention in both men and women (P
< 0.05). Baseline plasma levels of UA and F(2)-isoprostanes were higher (P </=
0.002) in men than in women. The F(2)-isoprostanes decreased on d 14 in men and
women (P </= 0.041), and UA decreased in men (P = 0.028). The concentrations of
vitamin C and 8-epiPGF(2alpha) were inversely correlated (r = -0.585, P =
0.0002). Plasma PGE(2) and MCP-1 concentrations decreased in men and women (P
</= 0.05) on d 14, but those of TNF-alpha, IL-1beta, and IL-6 did not change.
Consumption of the vegetable soup decreases oxidative stress and biomarkers of
inflammation, which indicates that the protective effect of vegetables may
extend beyond their antioxidant capacity.
PMID: 15514269 [PubMed - in process]
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