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Home > Archive > Impotence Support > February 2006 > PDE5 and all that........
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PDE5 and all that........
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| spikeislandism@hotmail.co.uk 2006-02-23, 11:28 am |
| Can anyone please explain how/why in some guys PDE5 starts to
"interfere" with things and break down cGMP?
Having done my own research and through discussions with others from
the group, I have come to the conclusion that for me, EVERYTHING else
is fine (ie no hormone troubles, diabetes, depression, circulation
issues, libido), yet somehow my body seems to be "interfering" with
cGMP making me experience *some* erection issues.
Can any of the knowledgable please fill me in?
thanks
Spike
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| Mungy@HorribleISP.gov 2006-02-23, 11:28 am |
| spikeislandism@hotmail.co.uk wrote:
>Can anyone please explain how/why in some guys PDE5 starts to
>"interfere" with things and break down cGMP?
PDE5 hydrolyzes cGMP in all males, not just some guys. It's part of
the normal process of detumescence after orgasm. If you really want to
find out more about the biochemistry read:
http://www.medscape.com/druginfo/mo...nograph&secid=2
(If that doesn't come through properly, just go to Medscape Drug Info
and type in Viagra)
particularly the Pharmacology, Pharmokinetics, and Chemisty. Although
this is the monograph for Viagra it explains the biochemistry of
erection and de-erection at least concerning the activities of PDE5
and the PDE5 inhibitors.
>Having done my own research and through discussions with others from
>the group, I have come to the conclusion that for me, EVERYTHING else
>is fine (ie no hormone troubles, diabetes, depression, circulation
>issues, libido), yet somehow my body seems to be "interfering" with
>cGMP making me experience *some* erection issues.
No one knows why some males suffer from ED as they age. You've hit on
some of the usual contributing factors but the knowledge peters out
when these have to be translated into the underlying biological
functions. For example: Are cells producing too little cGMP or too
much PDE5 or is the PDE5 being produced at an inappropriate time and
if so why? Is the problem higher up the line in the transmission of
information from the CNS to the appropriate cells and if so what is
the nature of the problem? Or even higher up in the instructions of
arousal emanating in the brain? No one knows the answer to these
questions. AFAIK there is no "norm" for the production of cGMP (or
PDE5 or any of the other chemicals involved) and there has been no
published effort to actually measure the levels of these chemicals in
action.
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