|
Home > Archive > Impotence Support > October 2004 > Androgen Therapy in Older Men
You are viewing an archived Text-only version of the thread.
To view this thread in it's original format and/or if you want to reply to
this thread please [click here]
| Author |
Androgen Therapy in Older Men
|
|
| Cargoman2001 2004-10-19, 10:07 pm |
| This is a bit off topic, but may be of some interest to a few of you.
The rationale, efficacy and safety of androgen therapy in older men: future
research and current practice recommendations.
Liu PY, Swerdloff RS, Veldhuis JD.
Division of Endocrinology, Department of Internal Medicine, Endocrine Research
Unit, Mayo Clinic, Mayo Medical and Graduate Schools of Medicine, 200 First
Street SW, Rochester, Minnesota 55905. liu.peter@mayo.edu.
Epidemiological studies indicate that normal male aging is associated with a
gradual and variable decline in blood testosterone concentrations and
unfavorable changes in muscle, bone, and fat that mimic those of androgen
deficiency in young men. These age-related reductions in muscle and bone mass
and increased fat mass may be responsible for other age-related changes,
including decreased muscle strength and physical function, changes in metabolic
function, and increased falls, fractures, and disability. Whether age-related
relative androgen deficiency truly causes any of these features requires
interventional studies specifically in older men, because aged tissues may not
remain androgen sensitive nor is such treatment necessarily safe.
A Medline search (years 1966 through January 2004, using search terms random
and androgen), supplemented by subsequent reference searches of retrieved
articles, identified randomized placebo-controlled studies of androgen therapy.
These studies show that androgen replacement in older men increases muscle and
reduces fat mass to a small degree, but to date has not improved muscle
strength, physical function, or insulin sensitivity, nor does it convincingly
improve bone density, although the latter effect is particularly dose
responsive. However, idiosyncratic adverse effects, such as disordered sleep
and breathing as well as polycythemia, are also dose responsive, suggesting
that dose escalation to increase efficacy may create or aggravate undesirable
side effects. Furthermore, the clinical safety of androgen therapy for
cardiovascular and prostatic disease is uncertain.
Under these circumstances, androgen supplementation is not recommended in
healthy older men. However, interim recommendations are available to help guide
appropriate and curb unnecessary androgen prescription for symptomatic older
men with low serum testosterone levels.
-----------------------------------------------------
PMID: 15472164 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/...db=PubMed&dopt=
Abstract&list_uids=15472164
From: weeklyedition@docguide.com
Date: 10/19/2004 5:11:05 PM US Mountain Standard Time
| |
| ernestnolan 2004-10-20, 7:07 pm |
| Hi,
This is not the majority view as the FDA approved testosterone replacement
therapy for men in 2000.
It is unbelievable but there is a huge amount of emotion and bias regarding
the use of hormone therapy for men. Some view it as giving whiskey to drunks
or poor people. Others view it as "against God's plan to interfere with the
aging process", but yet are doctors treating people to prevent their deaths.
Was told by Dr. Sipi before he died, hospital in NJ excluded him from
participating in the birth of babies because he treated couples with
fertility problems with hormones in some cases.
This is one article on that subject I found regarding the action taken by
the FDA on TRT for men.
http://www.findarticles.com/p/artic..._12/ai_60372586
ernestnolan
"Cargoman2001" <cargoman2001@aol.com> wrote in message
news:20041019212608.19972.00000827@mb-m18.aol.com...
> This is a bit off topic, but may be of some interest to a few of you.
>
> The rationale, efficacy and safety of androgen therapy in older men:
future
> research and current practice recommendations.
>
> Liu PY, Swerdloff RS, Veldhuis JD.
>
> Division of Endocrinology, Department of Internal Medicine, Endocrine
Research
> Unit, Mayo Clinic, Mayo Medical and Graduate Schools of Medicine, 200
First
> Street SW, Rochester, Minnesota 55905. liu.peter@mayo.edu.
>
> Epidemiological studies indicate that normal male aging is associated with
a
> gradual and variable decline in blood testosterone concentrations and
> unfavorable changes in muscle, bone, and fat that mimic those of androgen
> deficiency in young men. These age-related reductions in muscle and bone
mass
> and increased fat mass may be responsible for other age-related changes,
> including decreased muscle strength and physical function, changes in
metabolic
> function, and increased falls, fractures, and disability. Whether
age-related
> relative androgen deficiency truly causes any of these features requires
> interventional studies specifically in older men, because aged tissues may
not
> remain androgen sensitive nor is such treatment necessarily safe.
>
> A Medline search (years 1966 through January 2004, using search terms
random
> and androgen), supplemented by subsequent reference searches of retrieved
> articles, identified randomized placebo-controlled studies of androgen
therapy.
> These studies show that androgen replacement in older men increases muscle
and
> reduces fat mass to a small degree, but to date has not improved muscle
> strength, physical function, or insulin sensitivity, nor does it
convincingly
> improve bone density, although the latter effect is particularly dose
> responsive. However, idiosyncratic adverse effects, such as disordered
sleep
> and breathing as well as polycythemia, are also dose responsive,
suggesting
> that dose escalation to increase efficacy may create or aggravate
undesirable
> side effects. Furthermore, the clinical safety of androgen therapy for
> cardiovascular and prostatic disease is uncertain.
>
> Under these circumstances, androgen supplementation is not recommended in
> healthy older men. However, interim recommendations are available to help
guide
> appropriate and curb unnecessary androgen prescription for symptomatic
older
> men with low serum testosterone levels.
>
> -----------------------------------------------------
>
> PMID: 15472164 [PubMed - in process]
>
> http://www.ncbi.nlm.nih.gov/entrez/...db=PubMed&dopt=
> Abstract&list_uids=15472164
>
> From: weeklyedition@docguide.com
> Date: 10/19/2004 5:11:05 PM US Mountain Standard Time
>
>
|
| |
|
|