Politics and Medicine - How Olive Oil Fights Breast Cancer

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How Olive Oil Fights Breast Cancer

Ilena Rose

2005-01-15, 7:19 am

How Olive Oil Fights Breast Cancer

http://www.betterhumans.com/News/ne...ID=2005-01-10-6
Compound within dramatically cuts activity of a gene implicated in the
disease
Betterhumans Staff
1/10/2005 7:20 PM

A compound in olive oil dramatically cuts the activity of a gene
implicated in breast cancer, likely explaining the protective effect
of the staple of the Mediterranean diet.

Tests on breast cancer cell lines by American researchers have shown
that the compound, oleic acid, cuts the activity of the oncogene
Her-2/neu (also known as erb B-2). Excess expression of this gene has
been found in more than a fifth of breast cancer cases and been linked
with highly aggressive tumors with a poor prognosis.

Oleic acid was also found to boost treatment with trastuzumab
(Herceptin), a monoclonal antibody treatment that targets the
Her-2/neu gene and has proven to prolong the lives of people with
breast cancer.

"Our findings underpin epidemiological studies that show that the
Mediterranean diet has significant protective effects against cancer,
heart disease and aging," says Javier Menendez of Northwestern
University in Illinois.

Mediterranean medicine

Studies of southern European populations have shown that
monounsaturated fatty acids such as oleic acid may reduce breast
cancer risk. Animal studies, however, have had inconsistent
results—possibly because olive oil was administered in mixtures rather
than on its own.

In their research on cell lines, Menendez and colleagues found that
oleic acid cut the expression of Her-2/neu by up to 46% and assisted
with Herceptin treatment by promoting the death of breast cancer cells
having high levels of the oncogene. They also found that it increased
the expression of a tumor suppressor protein called p27Kip1.

Menendez says that the findings not only help in explaining how
dietary fatty acids regulate the malignant behavior of breast cancer
cells, but also suggest that oleic acid-based dietary interventions
could help delay or prevent Herceptin resistance.

The next step is to determine the molecular mechanisms by which oleic
acid inhibits Her-2/neu, because this action appears different from
that of Herceptin. Another goal is to study whether a high virgin
olive oil diet can decrease the aggressiveness of human breast tumors
in animals.

The research is reported in the Annals of Oncology (read abstract).

spiga

2005-01-15, 7:19 am

Just to let you all know, I have used olive oil since childhood--my
ancestors are of Italian/French origin. I am now dealing once again with
breast cancer--2nd time in 9 years. So, while, I'll continue to use it,
don't really know if it helps. regards, spiga
"Ilena Rose" <ilena@san.rr.com> wrote in message
news:5ip6u09997ej6u4ab7lm4tou8ijcrmbs02@4ax.com...
> How Olive Oil Fights Breast Cancer
>
> http://www.betterhumans.com/News/ne...ID=2005-01-10-6
> Compound within dramatically cuts activity of a gene implicated in the
> disease
> Betterhumans Staff
> 1/10/2005 7:20 PM
>
>
> A compound in olive oil dramatically cuts the activity of a gene
> implicated in breast cancer, likely explaining the protective effect
> of the staple of the Mediterranean diet.
>
> Tests on breast cancer cell lines by American researchers have shown
> that the compound, oleic acid, cuts the activity of the oncogene
> Her-2/neu (also known as erb B-2). Excess expression of this gene has
> been found in more than a fifth of breast cancer cases and been linked
> with highly aggressive tumors with a poor prognosis.
>
> Oleic acid was also found to boost treatment with trastuzumab
> (Herceptin), a monoclonal antibody treatment that targets the
> Her-2/neu gene and has proven to prolong the lives of people with
> breast cancer.
>
> "Our findings underpin epidemiological studies that show that the
> Mediterranean diet has significant protective effects against cancer,
> heart disease and aging," says Javier Menendez of Northwestern
> university in Illinois.
>
> Mediterranean medicine
>
> Studies of southern European populations have shown that
> monounsaturated fatty acids such as oleic acid may reduce breast
> cancer risk. Animal studies, however, have had inconsistent
> results-possibly because olive oil was administered in mixtures rather
> than on its own.
>
> In their research on cell lines, Menendez and colleagues found that
> oleic acid cut the expression of Her-2/neu by up to 46% and assisted
> with Herceptin treatment by promoting the death of breast cancer cells
> having high levels of the oncogene. They also found that it increased
> the expression of a tumor suppressor protein called p27Kip1.
>
> Menendez says that the findings not only help in explaining how
> dietary fatty acids regulate the malignant behavior of breast cancer
> cells, but also suggest that oleic acid-based dietary interventions
> could help delay or prevent Herceptin resistance.
>
> The next step is to determine the molecular mechanisms by which oleic
> acid inhibits Her-2/neu, because this action appears different from
> that of Herceptin. Another goal is to study whether a high virgin
> olive oil diet can decrease the aggressiveness of human breast tumors
> in animals.
>
> The research is reported in the Annals of Oncology (read abstract).
>

maison.mousse

2005-01-15, 7:19 am

adriangilbarco@yahoo.com a écrit dans le message
<1105569717.634499.237300@z14g2000cwz.googlegroups.com>...
>
>spiga Jan 11, 3:12 pm show options
>
>Newsgroups:
>alt.support.breast-implant,alt.support.cancer.breast,talk.politics.medicine
,misc.health.alternative,misc.headlines
>
>From: "spiga" <iamsp...@worldnet.att.net> - Find messages by this
>author
>Date: Tue, 11 Jan 2005 23:12:15 GMT
>Local: Tues, Jan 11 2005 3:12 pm
>Subject: Re: How Olive Oil Fights Breast Cancer
>Reply | Reply to Author | Forward | Print | Individual Message | Show
>original | Report Abuse
>
>Just to let you all know, I have used olive oil since childhood--my
>ancestors are of Italian/French origin. I am now dealing once again
>with
>breast cancer--2nd time in 9 years. So, while, I'll continue to use it,
>
>don't really know if it helps. regards, spiga
>
>
>I think genetics trumps diet everytime. Have you looked at your
>family history of cancers?
>

Olive oil is of course a healthy product but I agree that in the case of
breast cancer genetics are much more important than diet. I would not count
on any food or alternative treatment. If someone has breast cancer their
best chance is with the standard medical treatments even
if some are very unpleasent. If one wants to increase their use of olive
oil, add a LITTLE extra garlic ect on top of the
treatment fine! If one lives in France phytotherapy (no relationship at all
to herbalism) is sometimes used with chemo and radiation to lessen the
discomfort as
well to replace certain vitamins and other chemicals that may be lost.
Above all listen to your MD. If you have misgivings about
any advice seek a second opinion from another MD

JL

adriangilbarco@yahoo.com

2005-01-18, 7:13 pm

spiga Jan 11, 3:12 pm show options

Newsgroups:
alt.support.breast-implant,alt.support.cancer.breast,talk.politics.medicine,misc.health.alternative,misc.headlines

From: "spiga" <iamsp...@worldnet.att.net> - Find messages by this
author
Date: Tue, 11 Jan 2005 23:12:15 GMT
Local: Tues, Jan 11 2005 3:12 pm
Subject: Re: How Olive Oil Fights Breast Cancer
Reply | Reply to Author | Forward | Print | Individual Message | Show
original | Report Abuse

Just to let you all know, I have used olive oil since childhood--my
ancestors are of Italian/French origin. I am now dealing once again
with
breast cancer--2nd time in 9 years. So, while, I'll continue to use it,

don't really know if it helps. regards, spiga

I think genetics trumps diet everytime. Have you looked at your
family history of cancers?

maison.mousse

2005-01-18, 10:10 pm

Anth

2005-01-19, 2:11 am

http://cis.nci.nih.gov/fact/9_16.htm

"spiga" <iamspiga@worldnet.att.net> wrote in message
news:j3ZEd.3161$7N1.866@bgtnsc04-news.ops.worldnet.att.net...
> Just to let you all know, I have used olive oil since childhood--my
> ancestors are of Italian/French origin. I am now dealing once again with
> breast cancer--2nd time in 9 years. So, while, I'll continue to use it,
> don't really know if it helps. regards, spiga
> "Ilena Rose" <ilena@san.rr.com> wrote in message
> news:5ip6u09997ej6u4ab7lm4tou8ijcrmbs02@4ax.com...
>
>