| Dr. Jai Maharaj 2005-10-15, 6:06 pm |
| Turmeric douses chemo agent's killer effect
By Meenakshi Rao, in Indraprasth
The Pioneer
Sunday, October 16, 2005
Turmeric is all set to rest its case as the ultimate
healer and protector, not just in Ayurveda but in modern
medicine too. If all goes well, within some years,
turmeric will be used aggressively to prevent spread of
breast cancer to the lungs of women on chemotherapy.
According to a top level study by researchers at the
University of Texas MD Anderson Cancer Centre, curcumin,
the main ingredient of turmeric and the compound that
gives curry its mustard-yellow colour, inhibited
metastasis to the lungs of 60 mice with breast cancer.
The study funded by the US Department of Defence, reports
that the spice shuts down a protein active in the spread
of breast cancer to the lungs. The nontoxic natural
substance also reverses the effect of paclitaxel
(Taxol(tm) ) which triggers the spread of cancer. Taxol
is the frontline chemotherapy agent for breast cancer.
Because Taxol is so toxic, it produces the inflammatory
response triggering metastasis and curcumin suppresses it
by causing cell death.Researchers, who experimented on 60
mice with breast cancer, found that adding curcumin to
Taxol enhances its effect. Curcumin breaks down the dose,
making the therapy less toxic and just as powerful while
delivering the same level of efficacy. "We are excited
about the study results and the possible implications for
taking the findings into the clinic," says Bharat
Aggarwal, PhD, professor of cancer medicine in Anderson's
Department of Experimental Therapeutics.
"As of now, advanced breast cancer is a difficult foe to
fight with few proven treatments available after surgery,
chemotherapy and radiation," he says.
Curcumin is prescribed in Indian medicine as a potent
remedy for liver disorders, rheumatism, diabetic wounds,
runny nose, cough and sinusitis. Traditional Chinese
medicine uses curcumin as a treatment for diseases
associated with abdominal pain. Ancient Hindu medicine
used is a sprain and dislocation pain-killer. Curcumin
belongs to the ginger family.
Haldi fight
60 mice with breast cancer put in 4 groups. After tumours
grew to 10 mm (size of a pea), they were surgically
removed and mice fed curcumin diet.
Control group: Macroscopic lung metastasis was seen in 96
per cent mice.
Taxol only: Treatment only modestly reduced the incidence
of metastasis
Curcumin only and Taxol plus curcumin: Significantly
reduced both the incidence and numbers of visible lung
metastases.
Microscopic metastasis was found in the lungs of 28% mice
treated with curcumin-Taxol combo and there was no
macroscopic disease present. The micrometastasis present
consisted of only a few cells, suggesting that the
combination inhibited the growth of breast cancer tumour
cells that were in the lung before the tumours were
removed.
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"Think not that I am come to send peace on earth: I came not so send
peace, but a sword.
"For I am come to set a man at variance against his father, and the
daughter against her mother, and the daughter in law against her mother in
law.
"And a man's foes shall be they of his own household.
- Matthew 10:34-36.
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