Pathology - Increased red blood cells / hematocrit / sleep apnea

Author

Increased red blood cells / hematocrit / sleep apnea

ironjustice@aol.com

2006-09-12, 9:34 pm

Soooo .. this seems to .. say .. increased red blood cells are ..
associated with sleep apnea .

So the treatment would .. be .. ?

Would be .. ?

Iron .. reduction .. therapy ..

Heh .. heh ..

Does obstructive sleep apnea increase hematocrit?
Choi JB, Loredo JS, Norman D, Mills PJ, Ancoli-Israel S, Ziegler MG,
Dimsdale JE
Sleep Breath. 2006 Sep ; 10(3): 155-60

This study assessed the relationship between hematocrit levels and
severity of obstructive sleep apnea (OSA) and examined how this
relationship was affected by the degree of hypoxia as well as by
possible confounding factors. Two-hundred sixty three subjects (189 men
and 74 women) underwent nocturnal polysomnography with oximetry and had
measurements of hematocrit, hemoglobin, white blood cell count, body
mass index (BMI), blood pressure (BP), and 24-h urine norepinephrine
(NE). Patients with severe OSA [respiratory disturbance index (RDI)
>30] had significantly higher hematocrit values than patients with mild to moderate OSA or nonapneic controls (p<0.01). However, only one patient had a hematocrit in the range of clinical polycythemia. Hematocrit levels were significantly correlated with
BMI, BP, urinary NE, RDI, percent of time spent at oxygen saturation <90%, and with mean oxygen saturation. Multiple linear regression analysis revealed that mean oxygen saturation, RDI, and percent of time spent at oxygen saturation <90% were significant
predictors of hematocrit level, even after controlling for gender, ethnicity, 24-h urine NE, BMI, and BP (p<0.05). The severity of OSA is significantly associated with increased hematocrit, even after controlling for possible confounding variables. Howev
er, nocturnal hypoxemia in OSA does not usually lead to clinical polycythemia.

Definitions of hematocrit on the Web:

The percentage of red blood cells in the blood.
www.qualityoflife.org/services/NICU/glossary.cfm

Measure of the volume of red blood cells as a percentage of the total
blood volume. Normal in males is 43-49%, in females 37-43%.
bloodcenter.stanford.edu/about_blood/glossary.html

the measurement of the percentage of red blood cells found in a
specific volume of blood.
www.chkd.org/High_Risk_Pregnancy/glossary.asp

The percentage of packed red Blood cells found in a unit volume of
whole Blood.
www.bloodbook.com/glossary.html

A measure of red blood cells as a percentage of whole blood.
www.iwmf.com/glossary.htm

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

ironjustice@aol.com

2006-09-12, 9:34 pm

ironjustice@aol.com wrote:
> Soooo .. this seems to .. say .. increased red blood cells are ..
> associated with sleep apnea .
>
> So the treatment would .. be .. ?
>
> Would be .. ?
>
> Iron .. reduction .. therapy ..
>
> Heh .. heh ..
>
> Does obstructive sleep apnea increase hematocrit?
> Choi JB, Loredo JS, Norman D, Mills PJ, Ancoli-Israel S, Ziegler MG,
> Dimsdale JE
> Sleep Breath. 2006 Sep ; 10(3): 155-60
>
> This study assessed the relationship between hematocrit levels and
> severity of obstructive sleep apnea (OSA) and examined how this
> relationship was affected by the degree of hypoxia as well as by
> possible confounding factors. Two-hundred sixty three subjects (189 men
> and 74 women) underwent nocturnal polysomnography with oximetry and had
> measurements of hematocrit, hemoglobin, white blood cell count, body
> mass index (BMI), blood pressure (BP), and 24-h urine norepinephrine
> (NE). Patients with severe OSA [respiratory disturbance index (RDI)
h BMI, BP, urinary NE, RDI, percent of time spent at oxygen saturation <90%, and with mean oxygen saturation. Multiple linear regression analysis revealed that mean oxygen saturation, RDI, and percent of time spent at oxygen saturation <90% were significa
nt predictors of hematocrit level, even after controlling for gender, ethnicity, 24-h urine NE, BMI, and BP (p<0.05). The severity of OSA is significantly associated with increased hematocrit, even after controlling for possible confounding variables. How
ever, nocturnal hypoxemia in OSA does not usually lead to clinical polycythemia.[vbcol=seagreen]
>
> Definitions of hematocrit on the Web:
>
> The percentage of red blood cells in the blood.
> www.qualityoflife.org/services/NICU/glossary.cfm
>
> Measure of the volume of red blood cells as a percentage of the total
> blood volume. Normal in males is 43-49%, in females 37-43%.
> bloodcenter.stanford.edu/about_blood/glossary.html
>
> the measurement of the percentage of red blood cells found in a
> specific volume of blood.
> www.chkd.org/High_Risk_Pregnancy/glossary.asp
>
> The percentage of packed red Blood cells found in a unit volume of
> whole Blood.
> www.bloodbook.com/glossary.html
>
> A measure of red blood cells as a percentage of whole blood.
> www.iwmf.com/glossary.htm
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

In case you may wonder .. why .. there are so few with .. 'diagnosed'
... polycythemia .. "fitting the criteria" .. ?

They're .. all .. long .. dead ..

"Increased mortality, stroke, heart attack and hospitalization due to
congestive heart failure at .. 13.5 g/dL.."

Polycythemia is 'diagnosed' .. by .. them .. by .. 'criteria' of ..
$$$$ .. fully admitted .. "less false positives" ..

"18.5 g/dL for men and 16.5 g/dL for women"

http://www.orthobiotech.com/060420.html

The primary analysis of the composite endpoint showed a statistically
significant higher incidence of composite endpoint events -- consisting

of mortality, stroke, heart attack and hospitalization due to
congestive heart failure -- in the group of patients treated to the
investigational hemoglobin target of 13.5 g/dL, as compared to the
group treated to the hemoglobin target that is consistent with the
current product label, 11.3 g/dL.

http://www.emedicine.com/ped/topic1848.htm

The current diagnostic criteria for polycythemia vera is now based on
the World Health Organization (WHO) criteria for polycythemia vera,
which includes the following:

A criteria

A1 - Elevated red blood cell mass (>25% more than the mean normal
predicted value) or hemoglobin >18.5 g/dL in men or >16.5 g/dL in women
(or greater than the 99th percentile of method-specific reference range
for age, sex, and altitude of residence)

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk