| ironjustice@aol.com 2006-06-22, 9:25 pm |
| Iron Chelation as Therapy for HIV and Mycobacterium tuberculosis
Co-Infection Under Conditions of Iron Overload.
Meyer D
Curr Pharm Des. 2006; 12(16): 1943-7
Iron chelators, as treatment for conditions of iron overload, have
implications for AIDS and tuberculosis (TB) since excess iron in the
system assists HIV and Mycobacterium tuberculosis (M.tb)
multiplication. Excess iron, especially due to dietary habits, is
almost as common in sub-Saharan Africa as infections by the two
organisms. That HIV and M.tb influence each other's replication during
co-infection is well established, but in vitro evaluations of
concurrent infection of the two under conditions of iron overload and
determining whether chelators reverse the effect, are limited. This
review provides brief commentary on the possibility of iron chelators
presently in clinical use influencing simultaneous HIV-M.tb infections
during iron loading and the feasibility of evaluating this in vitro
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