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Home > Archive > Pathology > June 2006 > Lactoferrin inhibits urinary tract infection
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Lactoferrin inhibits urinary tract infection
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| ironjustice@aol.com 2006-06-16, 4:30 pm |
| Antiviral Res. 2006 Jun 2; [Epub ahead of print] Related Articles,
Links
Lactoferrin inhibits early steps of human BK polyomavirus infection.
Longhi G, Pietropaolo V, Mischitelli M, Longhi C, Conte MP, Marchetti
M, Tinari A, Valenti P, Degener AM, Seganti L, Superti F.
Department of Public Health Sciences, university of "La Sapienza",
Piazzale Aldo Moro, 5, 00185 Rome, Italy.
Lactoferrin, a member of the transferrin family, is a bi-globular iron
binding glycoprotein, found in milk, exocrine secretions of mammals,
and in secondary granules of polymorphonuclear neutrophiles that plays
an important role in the defence against various pathogenic
microorganisms. Previous studies in different virus-cell systems showed
that lactoferrin is a potent inhibitor of different enveloped and naked
virus infection. In this research we studied the effect of lactoferrin
on BK polyomavirus, a human naked double-stranded DNA virus responsible
for productive, persistent, and latent infections of the urinary tract.
Results obtained demonstrate that lactoferrin treatment prevents early
steps of BK virus infection in Vero cells, at the level of the
adsorption phase, probably through the interaction with capsidic
structures, although a lactoferrin-BK virus competition for cell
plasma-membrane receptors cannot be ruled out.
PMID: 16774792 [PubMed - as supplied by publisher]
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Tom
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| PeterB 2006-06-19, 4:27 pm |
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ironjustice@aol.com wrote:
> Antiviral Res. 2006 Jun 2; [Epub ahead of print] Related Articles,
> Links
>
>
> Lactoferrin inhibits early steps of human BK polyomavirus infection.
>
> Longhi G, Pietropaolo V, Mischitelli M, Longhi C, Conte MP, Marchetti
> M, Tinari A, Valenti P, Degener AM, Seganti L, Superti F.
>
> Department of Public Health Sciences, university of "La Sapienza",
> Piazzale Aldo Moro, 5, 00185 Rome, Italy.
>
> Lactoferrin, a member of the transferrin family, is a bi-globular iron
> binding glycoprotein, found in milk, exocrine secretions of mammals,
> and in secondary granules of polymorphonuclear neutrophiles that plays
> an important role in the defence against various pathogenic
> microorganisms. Previous studies in different virus-cell systems showed
> that lactoferrin is a potent inhibitor of different enveloped and naked
> virus infection. In this research we studied the effect of lactoferrin
> on BK polyomavirus, a human naked double-stranded DNA virus responsible
> for productive, persistent, and latent infections of the urinary tract.
> Results obtained demonstrate that lactoferrin treatment prevents early
> steps of BK virus infection in Vero cells, at the level of the
> adsorption phase, probably through the interaction with capsidic
> structures, although a lactoferrin-BK virus competition for cell
> plasma-membrane receptors cannot be ruled out.
>
> PMID: 16774792 [PubMed - as supplied by publisher]
Lactoferrin is a very interesting application in natural medicine. If
you have an intestinal virus, lactoferrin helps by binding with iron
that would otherwise have fed the virus. As for cell-loading iron, it
should be useful for drawing down iron stores over time, but I'm not
aware of research that documents such an effect, and it would be
ill-advised without professional guidance.
> --------------------------------------------------------------------------------
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk
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