Pathology - AUTOIMMUNITY

Author

AUTOIMMUNITY

ironjustice@aol.com

2006-06-10, 2:26 am

This article speaks to the thesis .. radiation induced damage seems to
be .. particularily .. coincidentally .. MIMICING .. the damage one
finds in .. AUTOIMMUNITY.

Since the active .. mode of operation .. OF cancer therapy is the
INDUCTION of massive amounts of free radicals / reative oxygen species
/ rust / oxidative stress .. the researchers propose .. 'autoimmunity'
... is .. CAUSED .. by .. free radicals / reative oxygen species / rust
/ oxidative stress

Free radical theory of autoimmunity.
Kannan S
Theor Biol Med Model. 2006 Jun 7; 3(1): 22

ABSTRACT: BACKGROUND: Despite great advances in clinical oncology, the
molecular mechanisms underlying the failure of chemotherapeutic
intervention in treating lymphoproliferative and related disorders are
not well understood. Hypothesis: A hypothetical scheme to explain the
damage induced by chemotherapy and associated chronic oxidative stress
is proposed on the basis of published literature, experimental data and
anecdotal observations. Brief accounts of multidrug resistance,
lymphoid malignancy, the cellular and molecular basis of autoimmunity
and chronic oxidative stress are assembled to form a basis for the
hypothesis and to indicate the likelihood that it is valid in vivo.
CONCLUSIONS: The argument set forward in this article suggests a
possible mechanism for the development of autoimmunity. According to
this view, the various sorts of damage induced by chemotherapy have a
role in the pattern of drug resistance, which is associated with the
initiation of autoimmunity.

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Tom

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babawali@world.com

2006-06-10, 8:27 am

Please read more closely what you post. It was about auto immunity from
use of chemo in cancer treatment, not radiation as you suggested. There
are many things that can be prooxidant, in this case the drugs used in
cancer treatment. Using info from another recent post of your's, free
iron to "rust" is not common because it is in a bound state.

ironjustice@aol.com

2006-06-10, 4:27 pm

babawali@world.com wrote:
> Please read more closely what you post. It was about auto immunity from
> use of chemo in cancer treatment, not radiation as you suggested. There
> are many things that can be prooxidant, in this case the drugs used in
> cancer treatment. Using info from another recent post of your's, free
> iron to "rust" is not common because it is in a bound state

>free iron to "rust" is not common

Contrary .. it .. seems to what you .. 'say' .. since one in three is
supposed to manifest .. diabetes .. the FACT that ALL diabetics have
free floating iron .. means your .. calculations .. are .. obviously ..
wanting ..

That happens when your stupidity is not kept in .. check ..

RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes

Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links

Common presence of non-transferrin-bound iron among patients with type
2 diabetes.

Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RC.

Department of Preventive Medicine, School of Medicine, Kyungpook
University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
lee...@knu.ac.kr.

OBJECTIVE: Recently, we reported increased cardiovascular disease
mortality among supplemental vitamin C users with type 2 diabetes in a
prospective cohort study. Because vitamin C may cause oxidative stress
in the presence of redox active iron, we hypothesized that
non-transferrin-bound iron (NTBI), a form of iron susceptible to redox
activity, may be present in patients with type 2 diabetes. RESEARCH
DESIGN AND METHODS: We measured serum NTBI levels using
high-performance liquid chromatography in 48 patients with known
diabetes (at least 5 years duration since diagnosis), 49 patients with
newly diagnosed diabetes, and 47 healthy control subjects (frequency
matched on age and sex). RESULTS: NTBI was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes.

Mean NTBI values varied significantly between the three groups, with
the highest values being observed in patients with known diabetes and
the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29 vs.

0=2E04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
saturation were very similar among the three groups, yet NTBI was
strongly associated with serum total iron (r =3D 0.74, P < 0.01) and
percent transferrin saturation (r =3D 0.70, P < 0.01) among the patients
with known diabetes. CONCLUSIONS: Consistent with our hypothesis, these

data demonstrate the common existence of NTBI in type 2 diabetic
patients with a strong gradient with severity. Prospective cohort
studies are required to clarify the clinical relevance of increased
NTBI levels.

PMID: 16644642 [PubMed - in process]

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Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
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DEAD PEOPLE WALKING=20
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babawali@world.com

2006-06-10, 4:27 pm

Don't change the subject, you confused radiation with chemo and drew a
false conclusion. The example where unbound iron is not bound iron is
silly, if it is not bound it is indeed unbound. Using info from one of
your recent posts, normally iron is bound..

ironjustice@aol.com

2006-06-10, 4:27 pm

ironjustice@aol.com

2006-06-10, 4:27 pm

babawali@world.com wrote:
> Don't change the subject, you confused radiation with chemo and drew a
> false conclusion. The example where unbound iron is not bound iron is
> silly, if it is not bound it is indeed unbound. Using info from one of
> your recent posts, normally iron is bound..

Whoops ..

Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic
Effectiveness
Kenneth A. Conklin, MD, PhD
Jonsson Comprehensive Cancer Center, David Geffen School of Medicine,
University of California, Los Angeles, kconklin@mednet.ucla.edu

Antineoplastic agents induce oxidative stress in biological systems.
During cancer chemotherapy, oxidative stress-induced lipid peroxidation
generates numerous electrophilic aldehydes that can attack many
cellular targets. These products of oxidative stress can slow cell
cycle progression of cancer cells and cause cell cycle checkpoint
arrest, effects that may interfere with the ability of anticancer drugs
to kill cancer cells. The aldehydes may also inhibit drug-induced
apoptosis (programmed cell death) by inactivating death receptors and
inhibiting caspase activity. These effects would also diminish the
efficacy of the treatment. The use of anti-oxidants during chemotherapy
may enhance therapy by reducing the generation of oxidative
stress-induced aldehydes.

Key Words: antioxidants =B7 apoptosis =B7 chemotherapy =B7 oxidative
stress

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING=20
http://tinyurl.com/zk9fk

babawali@world.com

2006-06-10, 4:27 pm

"Chemotherapy-Associated Oxidative Stress"

Exactly, you said first it was radiation related, thanks for correcting
yourself.