| ironjustice@aol.com 2006-06-04, 9:21 am |
| <<snip>>
Phlebotomy not only ameliorated the severity of hepatitis, but also
reduced serum malondialdehyde
<<snip>>
Hepatol Res. 2006 May 29; [Epub ahead of print] Links
Iron removal by phlebotomy for the prophylaxis of fulminant hepatitis
in a Wilson disease model of Long-Evans Cinnamon Rats.
Hayashi H, Wakusawa S, Yano M.
Department of Medicine, Aichi Gakuin university School of Pharmacy,
Kusumoto 1-100, Chikusa-ku, Nagoya 464-8650, Japan.
Long-Evans Cinnamon rats are an animal model of Wilson disease with a
compound load of copper and iron. However, the mechanisms of the high
mortality rate from fulminant hepatitis in the rats remain
undetermined. In this study, phlebotomy as an alternative for an
iron-deficient diet was investigated to modify hepatitis in the rats.
One group of female rats was treated with phlebotomy twice a week, and
the other group received blood tests only every 2 weeks. Liver
specimens were examined for biochemical non-heme iron and copper, and
histochemical trivalent iron. Although all rats examined had icteric
hepatitis around the age of 20 weeks, the mortality of fulminant
hepatitis was lower in phlebotomized rats than in control rats (1/18
versus 8/20, p<0.05). Phlebotomy not only ameliorated the severity of
hepatitis, but also reduced serum malondialdehyde. Non-heme iron in the
liver was the greatest in victims of fulminant hepatitis in the control
group. There was no difference in the hepatic copper content between
the two groups. The prognosis of hepatitis in the rats with Wilson
disease was hepatic non-heme iron-dependent, and iron removal by
phlebotomy was an effective prophylaxis against fulminant hepatitis.
PMID: 16737843 [PubMed - as supplied by publisher]
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