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Home > Archive > Pathology > June 2006 > Transfusion increases cancer mortality
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Transfusion increases cancer mortality
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| ironjustice@aol.com 2006-06-04, 9:21 am |
| Cancer-Specific Mortality Is Increased By Erythrocyte Transfusion In
Patients Undergoing Surgery For Renal Cell Carcinoma - AUA 2006
Main Category: Urology / Nephrology News
Article Date: 26 May 2006 - 3:00am (PDT)
UroToday.com - Routh and colleagues out of Mayo reviewed the records on
2442 renal surgeries for cancer to determine the relationship between
perioperative transfusions and cancer specific survival (CSS). Of
these, 36.3% of patients were transfused at least one unit.
The 5 year CSS was 83.1% for non-transfused patients versus 51.7% for
those that received perioperative blood products. Decreasing CSS was
associated with increasing number of units transfused.
This study is intriguing in that it, like in other malignancies,
demonstrates an affect of blood transfusions on survival. Whether this
reflects a true immunological phenomenon, or simply reflects that more
aggressive advanced tumors are associated with more blood loss during
surgical extirpation remains to be determined.
By Christopher G. Wood, MD
Abstract 733
Routh, JC, et al, Rochester, MN
UroToday - the only urology website with original content written by
global urology key opinion leaders actively engaged in clinical
practice.
To access the latest urology news releases from UroToday, go to:
http://www.urotoday.com
Copyright =A9 2006 - UroToday
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20
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<ironjustice@aol.com> wrote in message
news:1148744776.266319.93360@j33g2000cwa.googlegroups.com...
Cancer-Specific Mortality Is Increased By Erythrocyte Transfusion In
Patients Undergoing Surgery For Renal Cell Carcinoma - AUA 2006
This has been known for years. What's your point?
The section "This study is intriguing in that it, like in other
malignancies,
demonstrates an affect of blood transfusions on survival. Whether this
reflects a true immunological phenomenon, or simply reflects that more
aggressive advanced tumors are associated with more blood loss during
surgical extirpation remains to be determined." seems to have slipped your
comprehension
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| Steph wrote:
> <ironjustice@aol.com> wrote in message
> news:1148744776.266319.93360@j33g2000cwa.googlegroups.com...
> Cancer-Specific Mortality Is Increased By Erythrocyte Transfusion In
> Patients Undergoing Surgery For Renal Cell Carcinoma - AUA 2006
>
>
> This has been known for years. What's your point?
>
You must be psychic.It's only just been published.
(Or are those 'novices' at Mayo just waking up?
>
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"sam" <sam@profit.ot> wrote in message
news:coudnaOzj-aBOOXZnZ2dnUVZ8qadnZ2d@brightview.com...[vbcol=seagreen]
> Steph wrote:
>
>
> You must be psychic.It's only just been published.
> (Or are those 'novices' at Mayo just waking up?
You must be having a bit of difficulty with comprehension.
This paper has only just been published, but there are others going back at
least 15 years. As the paper says, actually.
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| ironjustice@aol.com 2006-06-04, 9:21 am |
| >This has been known for years. What's your point? <<
My POINT .. being .. 'they' / YOU admit to increased .. death .. BY ..
using YOUR / 'their' .. intervention / increasing red blood cell
count..
My POINT .. being .. 'they' / YOU admit to increased .. death .. BY ..
using YOUR / 'their' .. intervention / epoeitn / attempting to increase
red blood cell count.
One might CONSIDER USING MORTALITY AS A . marker . for effectiveness.
YOU / 'they' seem to CONVENIENTLY leave OUT .. mortality .. when
assessing effectiveness of an .. intervention.
Much like the MILLIONS of malaria stricken children YOU / 'they' have
KILLED . by .. intervention / attempted increase of red blood cell
count by iron supplementation.
"We didn't use mortality as a marker."
My POINT .. being .. 'they' / YOU admit to increased .. death .. BY ..
using YOUR / 'their' .. intervention / increasing red blood cell count
/ attempting to increase red blood cell count.
THAT .. increasing blood cells seem to lead to .. death ..
You see .. I . personally . SEE .. death .. AS .. a .. marker to USE .
YOU / 'they' seem to prefer .. "how do you rate your life" .. as a
marker.
I suppose if they died . then you might say . " oh shit .. he is
unavailable for questioning .. " .. and then you most likely would say
... "he dropped out" ..
In medical speak .
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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| ironjustice@aol.com 2006-06-04, 9:21 am |
| >>My POINT .. being .. 'they' / YOU admit to increased .. death .. BY ..
using YOUR / 'their' .. intervention / epoeitn / attempting to increase
red blood cell count. <<
EMEA says studies show increased mortality in epoetin-treated patients
Richard Woodman
Reuters Health
Posting Date: June 8, 2005
Last Updated: 2005-06-08 11:36:48 -0400 (Reuters Health)
LONDON (Agence de Presse Medicale for Reuters Health) - The label on
all epoetins is being updated to include information about a possible
increased risk of death in cancer patients taking these medications,
the European Medicines Agency said on Wednesday.
"Following the publication of two clinical studies showing an increased
mortality in cancer patients that were administered epoetin alfa and
epoetin beta, the Pharmacovigilance Working Party has looked at the
risk of tumour growth progression and thromboembolism in patients with
cancer who have been treated with epoetins," the agency's scientific
committee said in a statement.
The committee said it had agreed with the working party's
recommendation to update the product information of all epoetins used
in the treatment of anaemic cancer patients receiving chemotherapy.
The CHMP at its May meeting adopted changes for the product information
of centrally authorised epoetins in this indication -- including
blockbusters such as Amgen's Aranesp and Roche's NeoRecormon.
Harmonisation of the product information of nationally authorised
epoetins will be done in line with the relevant legal framework, the
statement added.
An agency spokesman was not immediately able to give details of the new
labels or say which two studies the committee was referring to. A
study, published in The Lancet in October 2003, found that that
although epoetin beta therapy can correct the anemia seen in head and
neck cancer patients undergoing radiotherapy, it does not improve
survival and may even impair disease control.
The findings were based on a randomized trial of 351 head and neck
cancer patients with anemia who were treated with radiotherapy. The
anemia resolved in 82% of epoetin-treated patients, compared with 15%
of those who received placebo.
But despite this seemingly beneficial effect, locoregional
progression-free survival was actually significantly worse in the
epoetin group. Compared with controls, patients in the epoetin group
were 69% more likely to experience locoregional progression and 39%
more likely to die.
The study authors speculated at the time that because some cancers
express erythropoietin receptors, stimulation of these receptors by the
medication might promote tumour growth.
The study was funded by Roche, which produces epoetin beta under the
trade name NeoRecormon. The company did not immediately return calls.
Copyright =A9 2006 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by
framing or similar means, is expressly prohibited without the prior
written consent of Reuters. Reuters shall not be liable for any errors
or delays in the content, or for any actions taken in reliance thereon.
Reuters and the Reuters sphere logo are registered trademarks and
trademarks of the Reuters group of companies around the world.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20
http://tinyurl.com/zk9fk
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<ironjustice@aol.com> wrote in message
news:1148771551.986393.300500@g10g2000cwb.googlegroups.com...[vbcol=seagreen]
using YOUR / 'their' .. intervention / epoeitn / attempting to increase
It's also been well shown that head and neck and cervix patients who are
anaemic have a higher recurrence rate and lower survival after treatment of
their cancers.
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| ironjustice@aol.com 2006-06-04, 9:21 am |
| >>It's also been well shown that head and neck and cervix patients who are
anaemic have a higher recurrence rate and lower survival after
treatment of
their cancers. <<
?????
You say that .. ON .. a thread which SPECIFICALLY shows .. INCREASED
death rate by .. use of epoetin ..
Epoetin is used to alleviate / treat .. anemia.
Soooo .. in effect you are .. saying .. "anemic people die more and
faster .. " .. when in FACT the article itself .. says .. "our treating
of people for anemia is killing them at a much higher and faster rate
... to be more precise at a 40% higher rate .." ..
You leave me no choice but to call you .. stupid ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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<ironjustice@aol.com> wrote in message
news:1148815214.896632.277790@y43g2000cwc.googlegroups.com...
> anaemic have a higher recurrence rate and lower survival after
> treatment of
> their cancers. <<
>
> ?????
>
> You say that .. ON .. a thread which SPECIFICALLY shows .. INCREASED
> death rate by .. use of epoetin ..
>
> Epoetin is used to alleviate / treat .. anemia.
>
> Soooo .. in effect you are .. saying .. "anemic people die more and
> faster .. " .. when in FACT the article itself .. says .. "our treating
> of people for anemia is killing them at a much higher and faster rate
> .. to be more precise at a 40% higher rate .." ..
>
> You leave me no choice but to call you .. stupid ..
>
It's like being savaged by a dead sheep.
It's a completely different issue. Anaemic patients do worse in many
cancers. You can't build an entire edifice on one paper, loony
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| ironjustice@aol.com 2006-06-04, 9:21 am |
| >>You can't build an entire edifice on one paper, loony <<
Seems you / 'they' said the SAME thing when I pointed out the .. FOLLY
... of giving iron to kids with .. malaria .. A DECADE AGO ..
Eh ..
Didn't listen and you / 'they' have succeeded in KILLING MILLIONS OF
KIDS .. millions .. of ..children ..
Big .. man ..
So .. keep your .. loony .. sht .. to yourself ..
Especially when you say crap like you JUST said ..
"anemic patients tend to DIE" .. ON a thread which SPECIFICALLY says
they DON'T .. die .. at ANY rate NEAR those who have their anemia ..
'treated' BY you / 'they' ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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