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Home > Archive > Pathology > June 2006 > Debilitating lethargy / iron
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Debilitating lethargy / iron
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| ironjustice@aol.com 2006-06-04, 9:21 am |
| Clinical expression of C282Y homozygous HFE haemochromatosis at 14
years of age.
Rossi E, Wallace DF, Subramaniam VN, St Pierre TG, Mews C, Jeffrey GP
Ann Clin Biochem. 2006 May ; 43(Pt 3): 233-6
A 14-year-old boy who presented with debilitating lethargy was shown to
have an elevated serum ferritin of 572 mug/L and a C282Y homozygous HFE
genotype. Liver iron concentration was measured non-invasively by
magnetic resonance imaging, which revealed a liver iron concentration
of 59 mumol/g dry weight (children's reference range <14). The early
phenotypic expression was further investigated by screening genomic DNA
for the presence of co-inherited mutations in genes responsible for
non-HFE haemochromatosis. Coding regions and splice sites in genes
encoding hepcidin and haemojuvelin were sequenced and previously
described mutations in ferroportin 1 and transferrin receptor 2 genes
were screened. Although no mutations were found, the most likely cause
for the early expression is the presence of novel mutations or gene(s).
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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| outsor@citynet.net 2006-06-04, 9:21 am |
| "haemochromatosis"
A genetic condition. Interesting that a genetic cause of iron overload
causes similar lethargy as does too low iron.
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| Marcus Aurelius 2006-06-04, 9:21 am |
| One of the clinical means that you can use to determine anemia is to
look at the patient's tongue.
If the tongue is pale, it may a sign of anemia.
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