| ironjustice@aol.com 2006-05-07, 6:27 pm |
| Serum vitamin-E levels and its relation to clinical features in
nonalcoholic fatty liver disease with elevated ALT levels.
Cankurtaran M, Kav T, Yavuz B, Shorbagi A, Halil M, Coskun T, Arslan S
Acta Gastroenterol Belg. 2006 Jan-Mar ; 69(1): 5-11
BACKGROUND: Oxidative stress and free oxygen radicals play an important
role in the progression from simple fatty liver to steatohepatitis.
Deficiency of antioxidants like vitamin-E has been reported to trigger
this progression. The main aims of our study were to measure plasma
vitamin-E levels in nonalcoholic fatty liver disease (NAFLD), to
explain its relationship with biochemical parameters and to examine the
possible therapeutic and prophylactic role of vitamin-E. METHODS: 52
patients with NAFLD and elevated liver function tests were enrolled.
After 6 months of follow-up with a standard low-fat, low-calorie diet,
changes in liver enzymes were evaluated. RESULTS: Deficiency of
vitamin-E was detected in 16 patients with NAFLD. Homogenous echo
pattern of the liver and attenuation was found to be significantly
higher in the low vitamin-E group (p = 0.03). The low vitamin-E group
had significantly higher levels of triglyceride (p = 0.02). After 6
months, patients in the low vitamin-E group did not respond to the diet
and no decrease in ALT levels was detected (p = 0.04). CONCLUSION: This
is the first study measuring the serum vitamin-E levels in nonalcoholic
fatty liver disease. A correlation was found between low vitamin-E
levels, high triglyceride levels, as well as sonographic findings, both
of which are negative prognostic factors causing progression of fatty
liver to steatohepatitis. Patients with low vitamin-E levels did not
respond to a classical diet for fatty liver disease. Based on the data,
we suggest that diet alone is not adequate for patients with fatty
liver, and vitamin-E supplementation should be added.
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