| ironjustice@aol.com 2006-04-21, 11:25 am |
| The benefits of vitamin C and vitamin E in children with
beta-thalassemia with high oxidative stress.
Dissayabutra T, Tosukhowong P, Seksan P
J Med Assoc Thai. 2005 Sep ; 88 Suppl 4: S317-21
The present study aimed to determine the benefits of vitamin C and
vitamin E as antioxidant supplements in beta-Thalassemia children who
are at risk of iron overload due to multiple blood transfusion and high
oxidative stress. Antioxidant status, oxidative products, plasma free
hemoglobin, total hemoglobin and bilirubin were discussed. Twenty
children who had laboratory confirmation of major beta-Thalassemia at
least 6 months with history of packed red cell transfusion without iron
chelation were recruited. The informed consent for blood sample
collection and antioxidant medication was performed. Most patients
(85%) had hyperferritinemia and all of them had high oxidative stress.
All of them had low vitamin C and vitamin E level at recruitment. Three
months after vitamin C and vitamin E supplementation, plasma vitamin C,
vitamin E and glutathione were significantly increased, while total
bilirubin was slightly decreased without significance. Other parameters
included total antioxidant status (TAS), plasma and erythrocyte
malondialdehyde (MDA), hemoglobin and plasma free hemoglobin had no
differences during the study period. CONCLUSION: B-Thalassemia major
children who had multiple blood transfusion are at risk in iron
overload and high oxidative stress. From the present study, no
significant improvement in raising hemoglobin and concerning low dose
vitamin C is not contraindication in beta-Thalassemia patients.
Therefore, vitamin C plus vitamin E supplementation have benefits more
than vitamin E alone in promoting antioxidant status and may enhance
liver function as total bilirubin tends to decrease.
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