| ironjustice@aol.com 2006-04-12, 11:29 am |
| Oral lactoferrin in HIV-1 vertically infected children: an
observational follow-up of plasma viral load and immune parameters.
Zuccotti GV, Salvini F, Riva E, Agostoni C
J Int Med Res. 2006 Jan-Feb ; 34(1): 88-94
Lactoferrin (LF) is a mammalian iron-binding glycoprotein with
antiviral effects. This preliminary study evaluated 6 months' LF (3
g/day, orally) treatment in 22 human immunodeficiency virus type 1
(HIV-1) vertically infected children. Plasma viral load and CD4+ cell
counts were assessed every 3 months; before, during and after LF
administration. No significant changes were observed during the
pre-treatment period. By 6 months, mean (+/- SD) plasma viral load
(log10) declined from 4.54 (+/- 0.65) to 4.28 (+/- 0.60); median
percentage CD4+ cell count increased from 21.5% to 24.5%. Two months
after treatment discontinuation, mean plasma viral load did not differ
significantly from baseline or month 6 levels, but the percentage CD4+
cell count remained significantly higher than the baseline value. LF
plus antiretroviral (ARV) therapy was more effective at increasing CD4+
cell count than LF alone. None of the patients showed any new
HIV-1-related symptoms at follow-up. LF might be a useful addition to
ARV therapy, but further large-scale studies are required.
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