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Home > Archive > Pathology > April 2006 > Iron overload reaching epidemic levels worldwide
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Iron overload reaching epidemic levels worldwide
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| ironjustice@aol.com 2006-04-11, 11:30 am |
| Role of L-type Ca2+ channels in iron transport and iron-overload
cardiomyopathy.
Oudit GY, Trivieri MG, Khaper N, Liu PP, Backx PH
J Mol Med. 2006 Apr 8;
Excessive body iron or iron overload occurs under conditions such as
primary (hereditary) hemochromatosis and secondary iron overload
(hemosiderosis), which are reaching epidemic levels worldwide. Primary
hemochromatosis is the most common genetic disorder with an allele
frequency greater than 10% in individuals of European ancestry, while
hemosiderosis is less common but associated with a much higher
morbidity and mortality. Iron overload leads to iron deposition in many
tissues especially the liver, brain, heart and endocrine tissues.
Elevated cardiac iron leads to diastolic dysfunction, arrhythmias and
dilated cardiomyopathy, and is the primary determinant of survival in
patients with secondary iron overload as well as a leading cause of
morbidity and mortality in primary hemochromatosis patients. In
addition, iron-induced cardiac injury plays a role in acute iron
toxicosis (iron poisoning), myocardial ischemia-reperfusion injury,
Friedreich ataxia and neurodegenerative diseases. Patients with iron
overload also routinely suffer from a range of endocrinopathies,
including diabetes mellitus and anterior pituitary dysfunction. Despite
clear connections between elevated iron and clinical disease, iron
transport remains poorly understood. While low-capacity divalent metal
and transferrin-bound transporters are critical under normal
physiological conditions, L-type Ca(2+) channels (LTCC) are
high-capacity pathways of ferrous iron (Fe(2+)) uptake into
cardiomyocytes especially under iron overload conditions. Fe(2+) uptake
through L-type Ca(2+) channels may also be crucial in other excitable
cells such as pancreatic beta cells, anterior pituitary cells and
neurons. Consequently, LTCC blockers represent a potential new therapy
to reduce the toxic effects of excess iron.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| PeterB 2006-04-11, 6:23 pm |
|
ironjustice@aol.com wrote:
> Role of L-type Ca2+ channels in iron transport and iron-overload
> cardiomyopathy.
> Oudit GY, Trivieri MG, Khaper N, Liu PP, Backx PH
> J Mol Med. 2006 Apr 8;
>
> Excessive body iron or iron overload occurs under conditions such as
> primary (hereditary) hemochromatosis and secondary iron overload
> (hemosiderosis), which are reaching epidemic levels worldwide. Primary
> hemochromatosis is the most common genetic disorder with an allele
> frequency greater than 10% in individuals of European ancestry, while
> hemosiderosis is less common but associated with a much higher
> morbidity and mortality. Iron overload leads to iron deposition in many
> tissues especially the liver, brain, heart and endocrine tissues.
> Elevated cardiac iron leads to diastolic dysfunction, arrhythmias and
> dilated cardiomyopathy, and is the primary determinant of survival in
> patients with secondary iron overload as well as a leading cause of
> morbidity and mortality in primary hemochromatosis patients. In
> addition, iron-induced cardiac injury plays a role in acute iron
> toxicosis (iron poisoning), myocardial ischemia-reperfusion injury,
> Friedreich ataxia and neurodegenerative diseases. Patients with iron
> overload also routinely suffer from a range of endocrinopathies,
> including diabetes mellitus and anterior pituitary dysfunction. Despite
> clear connections between elevated iron and clinical disease, iron
> transport remains poorly understood. While low-capacity divalent metal
> and transferrin-bound transporters are critical under normal
> physiological conditions, L-type Ca(2+) channels (LTCC) are
> high-capacity pathways of ferrous iron (Fe(2+)) uptake into
> cardiomyocytes especially under iron overload conditions. Fe(2+) uptake
> through L-type Ca(2+) channels may also be crucial in other excitable
> cells such as pancreatic beta cells, anterior pituitary cells and
> neurons. Consequently, LTCC blockers represent a potential new therapy
> to reduce the toxic effects of excess iron.
>
> Who loves ya.
> Tom
What evidence do the authors provide that either a genetic
predisposition or systemic iron overload are "reaching epidemic levels
worldwide?" The WHO sees just the opposite. The majority of humans
lack a diet sufficient in protein, and this leads to iron deficiency,
which is said to be the world's most chronic health risk. The fact
that iron overload is real (in those few it affects) jus means meat
should be consumed in moderation. And didn't Jesus eat fish, Tom?
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
>
>
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| ironjustice@aol.com 2006-04-12, 11:29 am |
| >>The majority of humans
lack a diet sufficient in protein, and this leads to iron deficiency<<
The person is BORN with excess iron .. and this SUFFICIENT iron is
never depleted ..
The person doesn't .. lose .. this iron ..it is treated as if it were
gold .. and it is recycled .. theoretically DYING with the iron your
mom gave you at birth .. somewhat .. diluted ....
The person NEVER loses this iron ..
It is recycled ..
The person is capable of absorbing up to 80% of the iron from the food
they are presented .. with ..
The body stores seven months worth of iron and this iron is IMPOSSIBLE
to deplete because simply in order to deplete it one would have to go
without food for at least seven months ..
Which is .. impossible ..
There is no iron deficiency ..
There may be malnourishment .. but .. NO .. iron deficiency ..
IMPOSSIBLE ..
[vbcol=seagreen]
Nooo .. He .. didn't ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| PeterB 2006-04-12, 1:24 pm |
|
ironjustice@aol.com wrote:
> lack a diet sufficient in protein, and this leads to iron deficiency<<
>
> The person is BORN with excess iron .. and this SUFFICIENT iron is
> never depleted ..
I don't know why you think people are born with excess iron. The fact
is, iron is lost at a rate of 1mg to 2mg per day through a variety of
pathways, not just blood loss. It's true that women during
menstruation lose more than men, but if it wasn't a dietary
requirement, it would be impossible to acquire iron deficiency anaemia.
> The person doesn't .. lose .. this iron ..it is treated as if it were
> gold .. and it is recycled .. theoretically DYING with the iron your
> mom gave you at birth .. somewhat .. diluted ....
Then explain iron deficiency anaemia. The fact that stored iron can
be used for necessary biological processes doesn't mean the supply is
inexhaustible. Iron deficiency anaemia is a life-threatening disease,
and for more common worldwide than iron overload.
> The person NEVER loses this iron ..
>
> It is recycled ..
>
> The person is capable of absorbing up to 80% of the iron from the food
> they are presented .. with ..
That contradicts everything I've ever seen in the medical literature.
The figure is closer to 5% for non-heme (plant-based), and 25% for heme
(meat-derived) iron.
> The body stores seven months worth of iron and this iron is IMPOSSIBLE
> to deplete because simply in order to deplete it one would have to go
> without food for at least seven months ..
Since people can't survive without food for 7 months, iron deficiency
anaemia must occur as a result of inadequate diet. What doesn't happen
in a few months can certainly happen over a period of years. And it
does.
> Which is .. impossible ..
>
> There is no iron deficiency ..
>
> There may be malnourishment .. but .. NO .. iron deficiency ..
You'll have to explain that one to me. Malnourishment has no practical
meaning outside a nutritional deficiency.
> IMPOSSIBLE ..
>
>
> Nooo .. He .. didn't ..
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
>
>
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| PeterB 2006-04-12, 1:24 pm |
|
Here is a link you might find interesting. It's a vegetarian website
that I didn't have time to read over completely, but what I did read
seems pretty consistent with what we know and seems to over good advice
on the dietary side of the equation.
PeterB
| |
| David Wright 2006-04-13, 1:20 am |
| In article <1144861932.643977.152080@i40g2000cwc.googlegroups.com>,
PeterB <pkm@mytrashmail.com> wrote:
>
>Here is a link you might find interesting. It's a vegetarian website
>that I didn't have time to read over completely, but what I did read
>seems pretty consistent with what we know and seems to over good advice
>on the dietary side of the equation.
>
>PeterB
What are you doing, hoping he'll go crazy looking for the missing
link?
-- David Wright :: alphabeta at prodigy.net
These are my opinions only, but they're almost always correct.
"If you can't say something nice, then sit next to me."
-- Alice Roosevelt Longworth
| |
| bwebb30 2006-04-13, 11:24 am |
| It's nice to see, once again, after a several year absence, things haven't
really changed here.....
Edward J. Mathes, RPA-C
Department of Imaging Sciences
PET/CT Center
"David Wright" <wright@l1000.prodigy.net> wrote in message
news:ydj%f.9821$%m4.9636@newssvr33.news.prodigy.com...
> In article <1144861932.643977.152080@i40g2000cwc.googlegroups.com>,
> PeterB <pkm@mytrashmail.com> wrote:
>
> What are you doing, hoping he'll go crazy looking for the missing
> link?
>
> -- David Wright :: alphabeta at prodigy.net
> These are my opinions only, but they're almost always correct.
> "If you can't say something nice, then sit next to me."
> -- Alice Roosevelt Longworth
>
>
>
| |
| PeterB 2006-04-13, 11:24 am |
|
David Wright wrote:
> In article <1144861932.643977.152080@i40g2000cwc.googlegroups.com>,
> PeterB <pkm@mytrashmail.com> wrote:
>
> What are you doing, hoping he'll go crazy looking for the missing
> link?
No, I think he found that already (in his view, at least.)
> -- David Wright :: alphabeta at prodigy.net
> These are my opinions only, but they're almost always correct.
> "If you can't say something nice, then sit next to me."
> -- Alice Roosevelt Longworth
| |
| PeterB 2006-04-13, 11:24 am |
|
bwebb30 wrote:
> It's nice to see, once again, after a several year absence, things haven't
> really changed here.....
What do you mean?
> Edward J. Mathes, RPA-C
> Department of Imaging Sciences
> PET/CT Center
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| Alf Christophersen 2006-04-14, 6:22 pm |
| On 14 Apr 2006 03:44:20 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
>http://www.thefreedictionary.com/impossible
>
>Who loves ya.
>Tom
>
>
>Jesus Was A Vegetarian!
Haha. I love it. Before I started to read I was about to write a
comment that ironjustice denies any occuring of anaemia. You just
defines it as non-existing.
Now, I would like to know what you are going to do if you get involved
in a car accident and loose most of your blood? (Denies a transfusion
since it is most healthy to be devoid of blood, maybe accepting
exchange the lost water fraction??)
I guess not. But, in fact then you accept anaemia exists. ?
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| Alf Christophersen 2006-04-14, 6:22 pm |
| On 14 Apr 2006 12:51:57 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
>in a car accident and loose most of your blood<<
>
>Any blood you lose is devoid of iron .. to a great extent ..
>
>The iron has been shunted into your .. spleen ..
Sorry, I can tell you will loose a lot of iron too. In the form of
hemoglobine.
| |
| David Wright 2006-04-15, 11:25 am |
| In article <q7q%f.24594$Mj.20093@twister.nyroc.rr.com>,
bwebb30 <bwebb30@yahoo.com> wrote:
>It's nice to see, once again, after a several year absence, things haven't
>really changed here.....
>
>Edward J. Mathes, RPA-C
>Department of Imaging Sciences
>PET/CT Center
Ain't it the truth, Ed? Some of the players change, though. Nice to
see you drop by.
-- David Wright :: alphabeta at prodigy.net
These are my opinions only, but they're almost always correct.
"If you can't say something nice, then sit next to me."
-- Alice Roosevelt Longworth
>
>"David Wright" <wright@l1000.prodigy.net> wrote in message
>news:ydj%f.9821$%m4.9636@newssvr33.news.prodigy.com...
>
>
| |
| David Wright 2006-04-15, 11:25 am |
| In article <1144935506.295840.125750@i39g2000cwa.googlegroups.com>,
PeterB <pkm@mytrashmail.com> wrote:
>
>David Wright wrote:
>
>No, I think he found that already (in his view, at least.)
Possibly so, but there was certainly no URL in your posting. Does
this make YOU the missing link?
-- David Wright :: alphabeta at prodigy.net
These are my opinions only, but they're almost always correct.
"If you can't say something nice, then sit next to me."
-- Alice Roosevelt Longworth
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