| ironjustice@aol.com 2006-04-11, 11:30 am |
| Increased lipid peroxidation and neuron specific enolase in treatment
refractory schizophrenics.
Medina-Hern=E1ndez V, Ramos-Loyo J, Luquin S, S=E1nchez LF,
Garc=EDa-Estrada J, Navarro-Ruiz A
J Psychiatr Res. 2006 Apr 3;
It is well-known that increased lipid peroxidation and failure of
antioxidant mechanisms leads to neuronal damage in schizophrenic
patients. However, this neurodegenerative mechanism has not been
studied in treatment refractory schizophrenics (TRS). Therefore, the
main purpose of this study was to determine neuronal damage in TRS in
comparison to non-refractory schizophrenics (NRS) by means of
quantitative analysis of lipid peroxidation and neuron specific enolase
(NSE) related to the psychopathology severity. Two groups of paranoid
schizophrenics, TRS and NRS, and a group of healthy controls (CO) were
assembled (n=3D13). Lipid peroxidation was analyzed through
spectrophotometry for quantification of malonaldehyde (MDA) and
4-hydroxynonenal (4-HNE) serum concentrations. As well, serum NSE was
quantified by radioimmunoassay (ELSA). Psychopathology was evaluated
using the brief psychiatric rating scale (BPRS) and the positive and
negative symptoms scale (PANSS). TRS showed significant higher
concentrations of lipoperoxides by-products and NSE, than NRS and CO.
Clinical scores also revealed a more severe pathology in TRS, than in
NRS. Raised lipoperoxidation correlated with higher delusions and
emotional withdrawal symptoms, and increased NSE correlated with a
lower flow of the conversation and lack of spontaneity. All these
results together suggest that TRS patients suffer a greater lipid
peroxidation and neuronal damage than NRS, apparently related to
worsening of some of the psychiatric symptoms.
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