| ironjustice@aol.com 2006-03-22, 3:40 pm |
| New derivatives of picolinic acid and nicotinic acid with
anticonvulsant activity.
Paruszewski R, Strupinska M, Rostafinska-Suchar G, Stables JP
Protein Pept Lett. 2005 Oct ; 12(7): 701-4
Previously obtained Pic-BZA is a potent anticonvulsant with low
neurotoxicity, but its half-time of action is only about 15 min. In
search for equally effective anticonvulsants but with a longer time of
action fourteen Pic-BZA analogs were obtained. The compounds were
evaluated in the Anticonvulsant Screening Project (ASP) of
Antiepileptic Drug Development Program (ADDP) of NIH. Picolinic acid
2-fluorobenzylamide (Pic-2-F-BZA, 7) appeared to be the most effective
compound of the series.
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