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Home > Archive > Pathology > March 2006 > Excess iron / severe virulent pneumonia
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Excess iron / severe virulent pneumonia
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| ironjustice@aol.com 2006-03-22, 3:40 pm |
| Antimicrobial activity of gallium against virulent Rhodococcus equiin
vitro and in vivo.
Harrington JR, Martens RJ, Cohen ND, Bernstein LR
J Vet Pharmacol Ther. 2006 Apr ; 29(2): 121-7
Rhodococcus equi, a facultative intracellular bacterium, causes severe
pneumonia in foals. Evidence suggests that most foals become infected
very early in life, when they have immature or ineffective innate
immune responses. This study evaluated the antimicrobial activity of
gallium against R. equi, as a potential chemoprophylactic and
therapeutic agent. Rhodococcus equi was grown in media with various
concentrations of gallium nitrate (GN), with and without excess iron.
GN significantly inhibited growth and killed R. equi, and these effects
were abolished with excess iron. Antimicrobial effects of Ga appear to
be related to its interference with iron metabolism. Mice were treated
orally with gallium maltolate (GaM), 10 or 50 mg/kg BW, or distilled
H(2)O prior to and after experimental infection with R. equi. Six days
post-infection, organs were harvested and R. equi concentrations
assessed, and serum gallium concentrations determined. GaM was absorbed
in a dose-dependent manner, and R. equi tissue burdens were greater in
control mice than in all GaM-treated mice. GaM may aid in the control
of disease by preventing development of overwhelming R. equi tissue
burdens prior to the establishment of requisite innate and adaptive
immune responses.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| Max C. 2006-03-22, 3:40 pm |
| That's interesting news... if you're a horse.
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| Carole 2006-03-22, 3:40 pm |
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<ironjustice@aol.com> wrote in message
news:1141746530.221564.306020@p10g2000cwp.googlegroups.com...
> Antimicrobial activity of gallium against virulent Rhodococcus equiin
> vitro and in vivo.
> Harrington JR, Martens RJ, Cohen ND, Bernstein LR
> J Vet Pharmacol Ther. 2006 Apr ; 29(2): 121-7
>
> Rhodococcus equi, a facultative intracellular bacterium, causes severe
> pneumonia in foals. Evidence suggests that most foals become infected
> very early in life, when they have immature or ineffective innate
> immune responses. This study evaluated the antimicrobial activity of
> gallium against R. equi, as a potential chemoprophylactic and
> therapeutic agent. Rhodococcus equi was grown in media with various
> concentrations of gallium nitrate (GN), with and without excess iron.
> GN significantly inhibited growth and killed R. equi, and these effects
> were abolished with excess iron. Antimicrobial effects of Ga appear to
> be related to its interference with iron metabolism. Mice were treated
> orally with gallium maltolate (GaM), 10 or 50 mg/kg BW, or distilled
> H(2)O prior to and after experimental infection with R. equi. Six days
> post-infection, organs were harvested and R. equi concentrations
> assessed, and serum gallium concentrations determined. GaM was absorbed
> in a dose-dependent manner, and R. equi tissue burdens were greater in
> control mice than in all GaM-treated mice. GaM may aid in the control
> of disease by preventing development of overwhelming R. equi tissue
> burdens prior to the establishment of requisite innate and adaptive
> immune responses.
>
> Who loves ya.
> Tom
>
Can anybody decipher this into just a few lines for those the scientifically
illiterate.
Carole
http://www.cellsalts.net
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| barryh46au@yahoo.com.au 2006-03-22, 3:41 pm |
| two lines:
garbage
garbage
three lines:
garbage
garbage
garbage
etc
Barry
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| ironjustice@aol.com 2006-03-22, 3:41 pm |
| >>Can anybody decipher this into just a few lines for those the scientifically
illiterate<<
[vbcol=seagreen]
pneumonia in foals. <<
Pretty straight forward ..
This bacteria causes pneumonia in baby horses ..
[vbcol=seagreen]
GN significantly inhibited growth and killed R. equi, and these effects
were abolished with excess iron. Antimicrobial effects of Ga appear to
be related to its interference with iron metabolism.<<
All pathogens need iron .. [bacteria is a pathogen] .. and by giving
gallium to the host OF the pathogen it 'somehow' disallowed the
pathogen from .. killing .. the .. host ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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