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Home > Archive > Pathology > March 2006 > Iron (Fe) is essential for the proliferation of cancer cells
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Iron (Fe) is essential for the proliferation of cancer cells
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| ironjustice@aol.com 2006-03-22, 3:40 pm |
| Anticancer Drug Des. 2001 Aug-Oct;16(4-5):195-207. Related Articles,
Links
The desferrithiocin (DFT) class of iron chelators: potential as
antineoplastic agents.
Kicic A, Chua AC, Baker E.
Department of Physiology, university of Western Australia, Nedlands,
Australia.
Iron (Fe) is essential for the proliferation of cancer cells. A
subgroup of the orthosubstituted phenolate class of Fe chelators,
desferrithiocin
[2-(3'-hydroxypyrid-2'-yl)4-methyl-delta2-thiazoline-4(S)-carboxylic
acid; DFT] and its analogues, have potential application in short-term
chemotherapy for cancer by Fe deprivation. Their effects on cell
proliferation, cell cycle progression, Fe uptake and toxicity were
therefore examined in adult and fetal rat and human hepatocellular
carcinoma (HCC) cell lines, as well as in normal cells. DFT was more
active than desferrioxamine, in clinical trials as an antineoplastic
agent, consistently inhibiting cell proliferation in all cell lines
(IC50 = 40 microM).
2-(2'-hydroxyphenyl-2'-yl)-delta2-thiazoline-4(S)-carboxylic acid was
the most active analogue (IC50 = 55-90 microM). Inhibition was affected
by chelator concentration and ability to prevent Fe uptake. The
fetal-cell-derived HCC was more susceptible than adult HCC.
Structure-activity studies revealed that thiazol methyl deletion
greatly diminished antiproliferative activity of the chelators but
stereochemical orientation of COOH around C4 had no effect. Removal of
the N from the pyridine ring restored antiproliferative activity.
Chelators inhibited DNA synthesis in the S phase. The chelators at
their IC50 concentration had little or no effect on Fe uptake in normal
cells. This apparent selectivity of these chelators for cancer cells,
coupled with their high activity, suggests that further investigation
is warranted.
PMID: 12049478 [PubMed - indexed for MEDLINE]
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Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| Max C. 2006-03-22, 3:40 pm |
| I have yet to fully figure out why you keep posting studies like this
in a nutrition group. Are you saying that we should stop eating foods
containing iron? If we go without iron, we get iron deficiency anemia.
Let that go for too long and we die. Hemoglobin can not be produced
without iron. Oxygen can not be distributed throughout the body
without hemoglobin.
So, what are you saying, man?
Max.
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| ironjustice@aol.com 2006-03-22, 3:40 pm |
| >>I have yet to fully figure out why you keep posting studies like this
in a nutrition group. Are you saying that we should stop eating foods
containing iron? If we go without iron, we get iron deficiency anemia.
Let that go for too long and we die. Hemoglobin can not be produced
without iron. Oxygen can not be distributed throughout the body
without hemoglobin.
So, what are you saying, man?
Max. <<
You store seven months worth of iron ..
There is no .. iron .. deficient .. people in the world ..
Anyone who has food .. has .. iron ..
The addition of iron to foods kills you ..
The eating of meat .. a HIGHLY absorbable form of iron leads to iron
toxicity .. elevated / abnormal levels of iron which .. oxidizes ..
destroying .. antioxidants .. and while in this state of high elevation
is FREE to be .. 'accessed' / used by .. pathogens .. bacteria .. fungi
... virus' and cancer cells for .. proliferation ..
Any 'anemia' .. you EVER .. run into .. is NOT .. iron deficient anemia
...
Low iron diet / reduced iron diet / iron restricted diet .. restricts
... infection ..
Low iron diet is around 7ppm iron .. lacto-vegetarian diet /
dairyvegetable .. diet ..
That diet has been used to lower iron levels in hepatitis patients ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| Manky Badger 2006-03-22, 3:40 pm |
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<ironjustice@aol.com> wrote in message
news:1141673799.426877.93520@e56g2000cwe.googlegroups.com...
> Any 'anemia' .. you EVER .. run into .. is NOT .. iron deficient anemia
Mrs X presented in haematology clinic with Hb 5.1 g/dl & MCV 72.1 fl.
Prescribed oral ferrous sulphate.
Six montyhs later Hb 11.3 g/l, MCV 82.3 fl.
Not iron deficient? One lives & learns.
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| Max C. 2006-03-22, 3:40 pm |
| Is your period key stuck? What's wrong with your keyboard?
I'd love to see the evidence you have that shows there no such thing as
iron deficiency anemia.
Here's another definition for you:
"Iron deficiency anemia is the most common form of anemia.
Approximately 20% of women, 50% of pregnant women, and 3% of men are
iron deficient. Iron is an essential component of hemoglobin, the
oxygen-carrying pigment in the blood. Iron is normally obtained through
the food in your diet and by recycling iron from old red blood cells.
Without it, the blood cannot carry oxygen effectively -- and oxygen is
needed for the normal functioning of every cell in the body."
http://www.nlm.nih.gov/medlineplus/...icle/000584.htm
I'm about as open minded as they come. I've even been told that I'm
open minded to a fault, but I'm sorry, unless you can post some
credible references to your claims, I can't possibly take anything
you've said seriously.
Max.
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| william lee 2006-03-22, 3:40 pm |
| your XXXXin gone man. go get a life rusty.
ironjustice@aol.com wrote:
>
>
>
>
> You store seven months worth of iron ..
>
> There is no .. iron .. deficient .. people in the world ..
>
> Anyone who has food .. has .. iron ..
>
> The addition of iron to foods kills you ..
>
> The eating of meat .. a HIGHLY absorbable form of iron leads to iron
> toxicity .. elevated / abnormal levels of iron which .. oxidizes ..
> destroying .. antioxidants .. and while in this state of high elevation
> is FREE to be .. 'accessed' / used by .. pathogens .. bacteria .. fungi
> .. virus' and cancer cells for .. proliferation ..
>
> Any 'anemia' .. you EVER .. run into .. is NOT .. iron deficient anemia
> ..
>
> Low iron diet / reduced iron diet / iron restricted diet .. restricts
> .. infection ..
>
> Low iron diet is around 7ppm iron .. lacto-vegetarian diet /
> dairyvegetable .. diet ..
>
> That diet has been used to lower iron levels in hepatitis patients ..
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
>
>
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
>
>
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| Alf Christophersen 2006-03-22, 3:41 pm |
| On 6 Mar 2006 11:36:39 -0800, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
>Low iron diet is around 7ppm iron .. lacto-vegetarian diet /
>dairyvegetable .. diet ..
Back to spinach greens, stinging nettle soup and parsley. Good for
your health ironjustice :-)
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