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Home > Archive > Pathology > October 2006 > What are the symptoms if acute cortisol poisioning?
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What are the symptoms if acute cortisol poisioning?
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| Radium 2006-10-07, 9:34 pm |
| Hi:
What are the symptoms if acute cortisol toxicity?
Cortisol is one of the chemicals released during episodes of extreme
pain.
Pain can cause syncope and even death due to its affects on the
autonomic nervous system. Usually, in the case of neurally-mediated
syncope [and any directly resulting complications], the heart slows and
contracts less forcefully and the blood vessels around the body widen.
Cortisol, however, seems to have the exact opposite affects of a
neurally-mediated syncope. Cortisol increase the heart's rate and force
of contractions and causes blood vessels to constrict [vasospasm].
Yet, I've heard claims that cortisol contributes to the death to those
who suffer fatal cardiovasculature affects of severe pain. If cortisol
raises blood pressure, shouldn't it save the individual from the
syncope and death resulting from the pain? That is where I am confused.
Severe pain increases parasympathatic tone and decreases sympathetic
tone. Cortisol does the opposite. So how does cortisol increase the
fatality associated with acute pain if cortisol has opposite actions of
the pain??
Thanks,
Radium
| |
| Jason Johnson 2006-10-07, 9:34 pm |
| In article <1160262665.912984.159900@i42g2000cwa.googlegroups.com>,
"Radium" <glucegen1@excite.com> wrote:
Hi:
What are the symptoms if acute cortisol toxicity?
Cortisol is one of the chemicals released during episodes of extreme
pain.
Pain can cause syncope and even death due to its affects on the
autonomic nervous system. Usually, in the case of neurally-mediated
syncope [and any directly resulting complications], the heart slows and
contracts less forcefully and the blood vessels around the body widen.
Cortisol, however, seems to have the exact opposite affects of a
neurally-mediated syncope. Cortisol increase the heart's rate and force
of contractions and causes blood vessels to constrict [vasospasm].
Yet, I've heard claims that cortisol contributes to the death to those
who suffer fatal cardiovasculature affects of severe pain. If cortisol
raises blood pressure, shouldn't it save the individual from the
syncope and death resulting from the pain? That is where I am confused.
Severe pain increases parasympathatic tone and decreases sympathetic
tone. Cortisol does the opposite. So how does cortisol increase the
fatality associated with acute pain if cortisol has opposite actions of
the pain??
Thanks,
Radium
~~~~~~~~~~~~~~~~~~~~~~~
Radium
You need to read "Adrenal Fatique" by James L. Wilson. I was amazed about
how complicated this subject is. I still don't understand this subject as
well as
Skipper understands it. Read the book and perhaps you will have your
questions answered. The adrenals are NOT like a brain. Hormones are sent
out by the adrenals and the result could be good or bad.
Jason
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
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| Skipper 2006-10-08, 4:28 pm |
|
Radium wrote:
> Hi:
>
> What are the symptoms if acute cortisol toxicity?
>
> Yet, I've heard claims that cortisol contributes to the death to those
> who suffer fatal cardiovasculature affects of severe pain. If cortisol
> raises blood pressure, shouldn't it save the individual from the
> syncope and death resulting from the pain? That is where I am confused.
This is rather a strange thing to be worried about. Are you worrying
about dying from a pain induced heart attack? Or do you have another
point?
Skipper
| |
| Radium 2006-10-08, 9:28 pm |
| Skipper wrote:
> Radium wrote:
>
>
> This is rather a strange thing to be worried about. Are you worrying
> about dying from a pain induced heart attack? Or do you have another
> point?
>
> Skipper
I am not worried about it. I am just interested in how cortisol [a
pro-sympathetic and anti-parasympathetic agent] could complicate the
neurocardiovascular effects caused by pain. As I said before, severe
pain causes an increase in parasympathetic tone and a decrease in
sympathetic tone. Cortisol does the exact opposite -- increasing
sympathetic tone and decreaseing parasympthatetic tone. So shouldn't
cortisol "rescue" the suffering individual from the fatalities
resulting from the neurocardiovascular relaxation caused by extreme
pain? It seems logical, that cortisol would.
However, some sources tell that cortisol is one of the hormones that
increases the neurogenic fatalities caused by pain. I don't know how
this is possible because cortisol stimulates the sympathetic nervous
system while relaxing the parasympathetic nervous system.
| |
| Jason Johnson 2006-10-08, 9:28 pm |
| In article <1160344453.987309.141990@m7g2000cwm.googlegroups.com>,
"Radium" <glucegen1@excite.com> wrote:
Skipper wrote:
> Radium wrote:
>
>
> This is rather a strange thing to be worried about. Are you worrying
> about dying from a pain induced heart attack? Or do you have another
> point?
>
> Skipper
I am not worried about it. I am just interested in how cortisol [a
pro-sympathetic and anti-parasympathetic agent] could complicate the
neurocardiovascular effects caused by pain. As I said before, severe
pain causes an increase in parasympathetic tone and a decrease in
sympathetic tone. Cortisol does the exact opposite -- increasing
sympathetic tone and decreaseing parasympthatetic tone. So shouldn't
cortisol "rescue" the suffering individual from the fatalities
resulting from the neurocardiovascular relaxation caused by extreme
pain? It seems logical, that cortisol would.
However, some sources tell that cortisol is one of the hormones that
increases the neurogenic fatalities caused by pain. I don't know how
this is possible because cortisol stimulates the sympathetic nervous
system while relaxing the parasympathetic nervous system.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Hello,
Skipper knows more about this subject than I know so pay more attention to
his words than my words. I seem to recall learning from one of the posts
or the book that I read entitled, "Adrenal Fatique" by James L. Wilson
that there are some cases where the body does not respond to effects of
Cortisol. If that is true, that could be the answer to your question. For
example, the cortisol is present but can NOT "rescue" the suffering
individual since his or her body is NOT responding to the Cortisol.
Jason
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
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| Radium 2006-10-08, 9:28 pm |
|
Jason Johnson wrote:
> In article <1160344453.987309.141990@m7g2000cwm.googlegroups.com>,
> "Radium" <glucegen1@excite.com> wrote:
>
> Skipper wrote:
>
> I am not worried about it. I am just interested in how cortisol [a
> pro-sympathetic and anti-parasympathetic agent] could complicate the
> neurocardiovascular effects caused by pain. As I said before, severe
> pain causes an increase in parasympathetic tone and a decrease in
> sympathetic tone. Cortisol does the exact opposite -- increasing
> sympathetic tone and decreaseing parasympthatetic tone. So shouldn't
> cortisol "rescue" the suffering individual from the fatalities
> resulting from the neurocardiovascular relaxation caused by extreme
> pain? It seems logical, that cortisol would.
>
> However, some sources tell that cortisol is one of the hormones that
> increases the neurogenic fatalities caused by pain. I don't know how
> this is possible because cortisol stimulates the sympathetic nervous
> system while relaxing the parasympathetic nervous system.
>
> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>
> Hello,
> Skipper knows more about this subject than I know so pay more attention to
> his words than my words. I seem to recall learning from one of the posts
> or the book that I read entitled, "Adrenal Fatique" by James L. Wilson
> that there are some cases where the body does not respond to effects of
> Cortisol. If that is true, that could be the answer to your question. For
> example, the cortisol is present but can NOT "rescue" the suffering
> individual since his or her body is NOT responding to the Cortisol.
> Jason
> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
I see, resistance to cortisol. Makes sense. Just like type 2 diabetes
causes resistance to insulin. Even though insulin is present -- and
often at extremely high levels -- the body fails to recognize the
insulin, thus the hormone loses its effect.
| |
|
| x-no-archive: yes
Radium wrote:
> I see, resistance to cortisol. Makes sense. Just like type 2 diabetes
> causes resistance to insulin. Even though insulin is present -- and
> often at extremely high levels -- the body fails to recognize the
> insulin, thus the hormone loses its effect.
>
Type 2 diabetes is a result of insulin resistance, which begins to occur
in all of us around age 30, precipitously at around age 40. Lifestyle,
diet and good genes can prevent the development of DM even in those who
are IR.
Susan
| |
| Jason Johnson 2006-10-08, 9:28 pm |
| In article <4otft9Fg85svU1@individual.net>, Susan@nothanks.org wrote:
x-no-archive: yes
Radium wrote:
> I see, resistance to cortisol. Makes sense. Just like type 2 diabetes
> causes resistance to insulin. Even though insulin is present -- and
> often at extremely high levels -- the body fails to recognize the
> insulin, thus the hormone loses its effect.
>
Type 2 diabetes is a result of insulin resistance, which begins to occur
in all of us around age 30, precipitously at around age 40. Lifestyle,
diet and good genes can prevent the development of DM even in those who
are IR.
Susan
~~~~~~~~~~~~~~~~~~~~~~~~~
Susan
Thanks for your excellent post.
Jason
~~~~~~~~~~~~~~~~~~~~~~~~
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